Day: November 21, 2022

Shao, Zhuzhou published the artcileBioorthogonal release of sulfonamides and mutually orthogonal liberation of two drugs, Application of Dbco-acid, the publication is Chemical Communications (Cambridge, United Kingdom) (2018), 54(100), 14089-14092, database is CAplus and MEDLINE.

Sulfonamide derivatives have been used in pharmaceutics for decades. Here we report a new approach to release sulfonamides efficiently using a bioorthogonal reaction of sulfonyl sydnonimines and dibenzoazacyclooctyne (DIBAC). The second-order rate constant of the cycloaddition reaction can be up to 0.62 M^-1s^-1, and the reactants are highly stable under physiol. conditions. Most significantly, we also discovered the mutual orthogonality between the sydnonimine-DIBAC and benzonorbornadiene-tetrazine cycloaddition pairs, which can be used for selective and simultaneous liberation of sulfonamide and primary amine drugs.

Chemical Communications (Cambridge, United Kingdom) published new progress about 1353016-70-2. 1353016-70-2 belongs to quinuclidine, auxiliary class Other Aromatic Heterocyclic,Carboxylic acid,Amide,Inhibitor,Inhibitor, name is Dbco-acid, and the molecular formula is C11H17BO3S, Application of Dbco-acid.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Duan, Ke published the artcileContacts transition induced stiffening mechanism in CNT-network/epoxy composites, Computed Properties of 1761-71-3, the publication is Carbon (2021), 767-774, database is CAplus.

The origin of abnormal enhancement in the elastic modulus of CNT-network/polymer composites is a fundamental but unresolved issue. Through mesoscale mol. dynamics simulations, we revealed that contrary to the conventional beliefs, it is not the improved interface load transfer ability among well contacted bundles but a contacts transition induced stiffening mechanism among weak contacted bundles that triggers such an abnormal enhancement. This is because the presence of epoxy mols. into the network pores leads to a remarkable densification effect on the composites thickness, improving the strength of those weak contact junctions between neighboring CNT layers and turning them into load-bearing contact junctions. Such a contacts transition phenomenon significantly increases the number of contact nodes and therefore load transfer paths within CNT-network, enabling more than one order of magnitude improvement in the composite modulus. Specifically, the proposed stiffening mechanism is correlated to the content of introduced epoxy, offering an effective route for tailoring the mech. properties of derived composites.

Carbon published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C13H26N2, Computed Properties of 1761-71-3.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Yace Mi published the artcileThe Roles Played by DMF in the Structure Formation of Epoxy-Based Porous Monolith, COA of Formula: C13H26N2, the publication is Polymer Science, Series B: Polymer Chemistry (2020), 62(5), 465-472, database is CAplus.

Abstract: Epoxy-based porous monoliths are prepared by chem. induced phase separation The roles played by N,N-dimethylformamide (DMF) in both curing and phase separation kinetics are studied in detail. It is found that the addition of DMF not only changes the speed of phase separation, but the way. Meanwhile, the occurrence of secondary phase separation is partly inhibited, which is in favor of the formation of skeletal network structure. In addition, the schematic pseudo phase diagrams were deduced, which are of great significance to understand the roles played by DMF for the targeted control of materials structure. The results show that by the addition of DMF, the phase diagram moves to the lower right, which means more porogen is needed to obtain skeletal network structure. The spinodal line moves toward the binodal line and the internal space of spinodal line is enlarged. Therefore, it becomes more available to obtain skeletal network structure.

Polymer Science, Series B: Polymer Chemistry published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C15H10O2, COA of Formula: C13H26N2.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Liu, Xue published the artcileTrifluoromethylation of Benzoic Acids: An Access to Aryl Trifluoromethyl Ketones, Product Details of C13H16O2, the publication is Organic Letters (2021), 23(12), 4930-4934, database is CAplus and MEDLINE.

The trifluoromethylation of benzoic acids with TMSCF₃ was achieved through nucleophilic substitution with the use of anhydrides as an in situ activating reagent. Under the reaction conditions, a wide range of carboxylic acids including the bioactive ones worked well, thus providing a facile and efficient method for preparing aryl trifluoromethyl ketones from the readily available starting materials.

Organic Letters published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C13H16O2, Product Details of C13H16O2.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Wang, Haibo published the artcilePincer thioamide and pincer thioimide palladium complexes catalyze highly efficient Negishi coupling of primary and secondary alkyl zinc reagents at room temperature, Quality Control of 20029-52-1, the publication is Chemistry – A European Journal (2009), 15(6), 1499-1507, database is CAplus and MEDLINE.

Two pincer thioamide and thioimide Pd^II complexes were synthesized from 2,6-bis(butylaminothiocarbonyl)pyridine and their structures were confirmed by X-ray anal. Both complexes were found to be efficient catalysts for Negishi couplings involving primary and secondary alkylzinc reagents bearing β-hydrogen atoms. At a concentration of 0.1- 0.5 mol% both catalysts readily promoted reactions at room temperature or even at 0 °C. The operational simplicity of these processes, in conjunction with the easy accessibility of both catalysts and substrates, promises synthetic utility of this new methodol. An experiment on a scale of 19.35 g carried out at very low catalyst loading (turnover number: 6100 000) highlighted the potential application of the catalytic system. Monoalkyl and dialkylzinc reagents displayed different reactivities and selectivities in reactions with aryl iodides, and isomerization in reactions involving acyclic secondary alkyl zinc derivatives was suppressed by using appropriate amounts of dialkylzinc reagents. Based on preliminary kinetic profiles and reaction evidence, three possible pathways are proposed for the reactions involving acyclic secondary alkyl zinc reagents to rationalize the difference between monoalkyl and dialkyl zinc derivatives

Chemistry – A European Journal published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C20H17FO4S, Quality Control of 20029-52-1.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Reinheimer, John D. published the artcileThe oxidation of β-aroylpropionic acids by sodium hypochlorite, Application of 4-Cyclohexylbenzoic acid, the publication is Ohio Journal of Science (1957), 26-8, database is CAplus.

The title acids and their oxidation products are good detection derivatives for the hydrocarbons and the acids themselves. For sec-butylbenzene, ethylbenzene, mesitylene, butylbenzene, m-xylene, benzene, propylbenzene, Tetralin, tert-butylbenzene, toluene, o-xylene, phenylcyclohexane, cumene, β-methylnaphthalene, naphthalene, biphenyl, acenaphthene, and fluorene, the m.ps. of the aroylpropionic acid derivatives are, resp., 95.5-6.5°, 107.5-8.5°, 109-9.5°, 111-13.5°, 112-13°, 116.5-17.5°, 120.5-2.5°, 121-2°, 123.5-25°, 127.5-8.5°, 130-1°, 136-6.5°, 139.5-41.5°, 165-6°, 172-3°, 187.5-88°, 209-10°, and 212-13°, and the m.ps. of the corresponding oxidation products are, resp., 92.5-3.5°, 111-12°, 148-50°, 101-2°, 125.1-6.6°, 121.7°, 141.4-1.9°, 152.2-53°, 164.1-5.2°, 180.5-81°, 165.4-5.9°, 191.5-3.5°, 116.6-18°, 228.5-30.5°, 182-3°, 223.5-4.5°, 217-17.5°, and above 250° (sublimes). The oxidizing solution was prepared by dissolving 2 g. NaOH in 40 ml. 5.25% NaOCl and diluting to 100 ml.; 1 g. of aroylpropionic acid was dissolved therein and warmed on a water bath for 20-30 min., refluxed 0.5 hr., filtered, cooled, and precipitated with SO₂. The water-washed derivative was recrystallized from ethanol or ethanol-water; yields for the various oxidation derivatives ranged from 52 to 97%.

Ohio Journal of Science published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C13H16O2, Application of 4-Cyclohexylbenzoic acid.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Li, Hui published the artcileWell-defined DNA-polymer miktoarm stars for enzyme-resistant nanoflares and carrier-free gene regulation, Application of Dbco-acid, the publication is Bioconjugate Chemistry (2020), 31(3), 530-536, database is CAplus and MEDLINE.

Herein, we report a star-architectured poly(ethylene glycol) (PEG)-oligonucleotide nanoconjugate of a well-defined mol. structure. Based upon fullerene C₆₀ cores, each star bears precisely 1 DNA strand and 11 polymer chains. The elevated PEG d. provides the DNA with steric selectivity: the DNA is significantly more resistant to nuclease digestion while remaining able to hybridize with a complementary sequence. The degree of resistance increases as the centers of mass for the DNA and fullerene are closer together. Such steric selectivity reduces protein-related background signals of the nanoflares synthesized from these miktoarm star polymers. Importantly, the stars improve cellular uptake and regulate gene expression as a non-cytotoxic, single-entity antisense agent without the need for a transfection carrier.

Bioconjugate Chemistry published new progress about 1353016-70-2. 1353016-70-2 belongs to quinuclidine, auxiliary class Other Aromatic Heterocyclic,Carboxylic acid,Amide,Inhibitor,Inhibitor, name is Dbco-acid, and the molecular formula is C19H15NO3, Application of Dbco-acid.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Liu, Chong published the artcileStrain-Promoted Click Modification of a Mesoporous Metal-Organic Framework, Application of Dbco-acid, the publication is Journal of the American Chemical Society (2012), 134(46), 18886-18888, database is CAplus and MEDLINE.

Strain-promoted click chem. was used to post-synthetically modify the pore walls of azide-functionalized mesoporous bio-MOF-100 (N₃-bio-MOF-100). The reactions proceed in high yield and produce no byproduct. This new method was used to introduce various functional groups into the MOF mesopores, including succinimidyl ester bioconjugation moieties that allow for straightforward coupling of biomols. to the pore walls.

Journal of the American Chemical Society published new progress about 1353016-70-2. 1353016-70-2 belongs to quinuclidine, auxiliary class Other Aromatic Heterocyclic,Carboxylic acid,Amide,Inhibitor,Inhibitor, name is Dbco-acid, and the molecular formula is C19H15NO3, Application of Dbco-acid.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Eltayeb, Mohanad published the artcileCarbodiimide-Assisted Synthesis of High Purity Bis(cyclic carbonate) Under Atmospheric Conditions for Preparation of Non-Isocyanate Polyurethane, SDS of cas: 1761-71-3, the publication is Journal of Polymers and the Environment (2021), 29(6), 1880-1893, database is CAplus.

The cyclic carbonates as non-isocyanate polyurethane (NIPU) precursors are usually prepared via CO₂ fixation under harsh conditions for a satisfactory conversion rate, which is energy-intensive. Herein, cyclic carbonate was prepared under ambient conditions with high purity and yield using a water-soluble ethyl-(N’,N’-dimethylamino)propylcarbodiimide hydrochloride (EDC) to provide a favored industrialization method. The glycerol carbonate was reacted with a furan-based dicarboxylic acid using EDC to evolve cyclic carbonates, followed by the aminolysis with different chem. structural amines to produce bio-based NIPUs. The effects of the reaction parameters on the yield and purity of bis(cyclic carbonate) were investigated. The results showed that the synthesized bis(cyclic carbonate) have a purity of 99% and a yield of > 70%. The different structures of the diamines exhibited different reactivity and mol. weights in the order of multi-functional amine > linear amine > cyclic amine. All the synthesized furan-based NIPUs presented excellent thermal stability above 350°C and glass transition temperature in the range of 51.9°C to 99.6°C. The result demonstrates the potential of this environmentally benign strategy to prepare high-performance bio-based NIPUs with interesting properties even for biomedical applications.

Journal of Polymers and the Environment published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C13H26N2, SDS of cas: 1761-71-3.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Shi, Shuai published the artcileA mild, general, and metal-free method for site-specific deuteration induced by visible light using D₂O as the source of deuterium atoms, Application In Synthesis of 162515-68-6, the publication is Green Chemistry (2020), 22(3), 669-672, database is CAplus.

A radical deuteration procedure using D₂O as the source of deuterium atoms is strongly preferred in terms of mildness, sustainability, and cost. Herein, a radical approach for site-specific, highly efficient and metal-free deuteration using D₂O under visible light conditions was disclosed. This desulfurization-deuteration strategy features mild conditions, broad substrate scope, highly efficient D-incorporation, excellent functional group compatibility, sustainable energy and is hardly affected by substrate steric factors.

Green Chemistry published new progress about 162515-68-6. 162515-68-6 belongs to quinuclidine, auxiliary class Thiol,Carboxylic acid,Aliphatic cyclic hydrocarbon, name is 2-(1-(Mercaptomethyl)cyclopropyl)acetic acid, and the molecular formula is C6H13N3O2, Application In Synthesis of 162515-68-6.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider