Sekhar, B. V. V. N. Chandra published the artcileSynthesis of Montelukast sodium via an ester intermediate; synthesis and characterization of impurities, HPLC of Formula: 162515-68-6, the publication is International Journal of Pharma and Bio Sciences (2011), 2(3), 399-407, database is CAplus.
Novel synthetic approaches for the synthesis of a leukotriene receptor antagonist, Montelukast sodium [i.e., 1-[[[(1R)-1-[3-[(1E)-2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic acid sodium salt] were designed. Reduction of the starting material [methyl (E)-2-[3-[3-[2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-3-oxopropyl]benzoate] provided an alc. compound and the formation of montelukast dicyclohexylamine was accomplished by subsequent introduction of (mercaptomethyl)cyclopropaneacetic acid. The current study also deals with the synthesis and characterization of reaction products which are classified as impurities of Montelukast sodium. Impurities and byproducts reported here included a sulfine (sulfoxide), (S)-montelukast (acid), etc.
International Journal of Pharma and Bio Sciences published new progress about 162515-68-6. 162515-68-6 belongs to quinuclidine, auxiliary class Thiol,Carboxylic acid,Aliphatic cyclic hydrocarbon, name is 2-(1-(Mercaptomethyl)cyclopropyl)acetic acid, and the molecular formula is C10H16Br3N, HPLC of Formula: 162515-68-6.
Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
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