Zhang, Niu-niu published the artcileDesign, synthesis, and biological evaluation of m-amidophenol derivatives as a new class of antitubercular agents, Computed Properties of 20029-52-1, the publication is MedChemComm (2018), 9(8), 1293-1304, database is CAplus and MEDLINE.
A series of m-amidophenol derivatives, e.g., I and II, were designed and synthesized. Their antitubercular activities were evaluated in vitro against M. tuberculosis strains H37Ra and H37Rv and clin. isolated multidrug-resistant M. tuberculosis strains. Ten compounds displayed minimal inhibitory concentrations (MICs) against M. tuberculosis H37Ra below 2.5μg mL-1 and compound I was the most active compound (MIC = 0.625μg mL-1). Compounds I and II also showed potent inhibitory activity against M. tuberculosis H37Rv (MIC = 0.39 γ mL-1) and several clin. isolated multidrug-resistant M. tuberculosis strains (MIC = 0.39-3.125μg mL-1). The compounds did not show inhibitory activity against normal Gram-pos. and Gram-neg. bacteria. They exhibited low cytotoxicity against HepG2 and RAW264.7 cell lines. The results demonstrated m-amidophenol as an attractive scaffold for the development of new antitubercular agents.
MedChemComm published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C7H13BrSi, Computed Properties of 20029-52-1.
Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider