Zhao, Guohua published the artcileSynthesis of potent and selective 2-azepanone inhibitors of human tryptase, Quality Control of 20029-52-1, the publication is Bioorganic & Medicinal Chemistry Letters (2004), 14(2), 309-312, database is CAplus and MEDLINE.
The serine protease tryptase has been associated with a broad range of allergic and inflammatory diseases and, in particular, has been implicated as a critical mediator of asthma. The inhibition of tryptase therefore has the potential to be a valuable therapy for asthma. The synthesis, employing solution phase parallel methods, and SAR of a series of novel 2-azepanone tryptase inhibitors are presented. One member of this series, I, was identified as a potent inhibitor of human tryptase (IC50 38 nM) with selectivity ≤330-fold vs. related serine proteases (trypsin, plasmin, uPA, tPA, APC, alpha-thrombin, and FXa).
Bioorganic & Medicinal Chemistry Letters published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C8H7ClO3, Quality Control of 20029-52-1.
Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider