Hodgson, Sabrina M. published the artcileReproducible Dendronized PEG Hydrogels via SPAAC Cross-Linking, Synthetic Route of 1353016-70-2, the publication is Biomacromolecules (2017), 18(12), 4054-4059, database is CAplus and MEDLINE.
A common issue with hydrogel formulations is batch-to-batch irreproducibility, originating from poorly-defined polymer precursors. Here, we report the use of dendritic polymer end-groups to address this issue and maintain reproducibility between batches of poly(ethylene glycol) (PEG) hydrogels. Specifically, we synthesized two end-functionalized PEG chains, one with azide-terminated first- and second-generation dendrons, and the other with strained cyclooctynes. The two complementary azide and alkyne polymers react via the Strain-Promoted Alkyne-Azide Cycoladdn. (SPAAC) to produce hydrogels quickly in the absence of addnl. reagents or catalyst, at low polymer concentrations Hydrogels made with first-generation dendrons gelled in minutes and exhibited a small degree of swelling when incubated in PBS buffer at 37°C, while hydrogels made from second-generation dendrons gelled in seconds with almost no swelling upon incubation at 37°C. In both cases, the hydrogels proved reproducible, resulting in identical Young’s Modulus (YM) values from different batches. The hydrogels prepared with second-generation dendrons were seeded with human mesenchymal stem cells (hMSCs), and showed high cell viability, as well as cell spreading over a two-week timeframe. These studies show that the SPAAC hydrogels are non-cytotoxic, and are capable of supporting cell growth.
Biomacromolecules published new progress about 1353016-70-2. 1353016-70-2 belongs to quinuclidine, auxiliary class Other Aromatic Heterocyclic,Carboxylic acid,Amide,Inhibitor,Inhibitor, name is Dbco-acid, and the molecular formula is C19H15NO3, Synthetic Route of 1353016-70-2.
Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider