Day: November 23, 2022

Duan, Jiang published the artcileDisilyl Bis(Secondary Amine)-Enabled Epoxy Ring-Opening and Silylotropic N → O Migration Leading to Low Dielectric Epoxy Copolymers, HPLC of Formula: 1761-71-3, the publication is Macromolecules (Washington, DC, United States) (2021), 54(14), 6947-6955, database is CAplus.

This work presents a strategy for fabricating low dielec. epoxy copolymers through copolymerizing bisphenol A diglycidyl ether with N,N’-disilyl bis(secondary amine)s, a series of difunctional silylamines synthesized by silylation of bis(secondary amine)s. A study on the model reaction of monoepoxy with monofunctional silylamines identified that the reaction proceeded smoothly in THF with Mg(ClO₄)₂ catalysis and mechanistically through sequential silylamine-induced epoxy ring-opening and silylotropic N → O migration, a process with favorable Gibbs free energy changes as confirmed by d. functional theory calculations The copolymers demonstrated remarkably low dielec. constants and dielec. losses due to the formation of the low-polarizable silyloxyl instead of the hydroxyl group in polymerization and the enlarged mol. free volume In addition, the copolymers showed desirable toughness, hydrophobicity, and thermal stability. As a tool to achieve these desirable features, the strategy developed in this work may find promising application in designing low dielec. epoxy resin materials for use in the microelectronic field.

Macromolecules (Washington, DC, United States) published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C13H26N2, HPLC of Formula: 1761-71-3.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Hodgson, Sabrina M. published the artcileReproducible Dendronized PEG Hydrogels via SPAAC Cross-Linking, Synthetic Route of 1353016-70-2, the publication is Biomacromolecules (2017), 18(12), 4054-4059, database is CAplus and MEDLINE.

A common issue with hydrogel formulations is batch-to-batch irreproducibility, originating from poorly-defined polymer precursors. Here, we report the use of dendritic polymer end-groups to address this issue and maintain reproducibility between batches of poly(ethylene glycol) (PEG) hydrogels. Specifically, we synthesized two end-functionalized PEG chains, one with azide-terminated first- and second-generation dendrons, and the other with strained cyclooctynes. The two complementary azide and alkyne polymers react via the Strain-Promoted Alkyne-Azide Cycoladdn. (SPAAC) to produce hydrogels quickly in the absence of addnl. reagents or catalyst, at low polymer concentrations Hydrogels made with first-generation dendrons gelled in minutes and exhibited a small degree of swelling when incubated in PBS buffer at 37°C, while hydrogels made from second-generation dendrons gelled in seconds with almost no swelling upon incubation at 37°C. In both cases, the hydrogels proved reproducible, resulting in identical Young’s Modulus (YM) values from different batches. The hydrogels prepared with second-generation dendrons were seeded with human mesenchymal stem cells (hMSCs), and showed high cell viability, as well as cell spreading over a two-week timeframe. These studies show that the SPAAC hydrogels are non-cytotoxic, and are capable of supporting cell growth.

Biomacromolecules published new progress about 1353016-70-2. 1353016-70-2 belongs to quinuclidine, auxiliary class Other Aromatic Heterocyclic,Carboxylic acid,Amide,Inhibitor,Inhibitor, name is Dbco-acid, and the molecular formula is C19H15NO3, Synthetic Route of 1353016-70-2.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Babij, Nicholas R. published the artcileStereocontrolled Synthesis of Bicyclic Sulfamides via Pd-Catalyzed Alkene Carboamination Reactions. Control of 1,3-Asymmetric Induction by Manipulating Mechanistic Pathways, Safety of 2′-(Dicyclohexylphosphino)-N2,N2,N6,N6-tetramethyl-[1,1′-biphenyl]-2,6-diamine, the publication is Organic Letters (2014), 16(12), 3412-3415, database is CAplus and MEDLINE.

Arylmethyl and allylic cyclic sulfamides such as pyrroloisothiadiazinediones and pyridoisothiadiazinedione I [R = H, H₂C:CHCH₂; R¹ = Ph, 4-t-BuC₆H₄, 4-MeOC₆H₄, 4-PhCOC₆H₄, 2-MeC₆H₄, 1-cyclohexenyl, Me(CH₂)₇CH:CH; X = CH₂, CH₂CH₂; PMP = 4-MeOC₆H₄] were prepared in 43-89% yields and in 5:1-13:1 diastereoselectivities by intramol. alkene carboamination reactions of allyl-substituted heteroaryl sulfamides such as II (R = H, H₂C:CHCH₂; X = CH₂, CH₂CH₂) with aryl triflates R¹OTf [R¹ = Ph, 4-t-BuC₆H₄, 4-MeOC₆H₄, 4-PhCOC₆H₄, 2-MeC₆H₄, 1-cyclohexenyl, Me(CH₂)₇CH:CH] in the presence of Pd(OAc)₂ and the phosphine ligand CPhos III (Cy = cyclohexyl) in tert-butanol. The ligands of and conditions for palladium-catalyzed carboamination reactions may be tuned to favor either anti- and syn-aminopalladation reactions and thus to obtain different product diastereomers.

Organic Letters published new progress about 1160556-64-8. 1160556-64-8 belongs to quinuclidine, auxiliary class Mono-phosphine Ligands, name is 2′-(Dicyclohexylphosphino)-N2,N2,N6,N6-tetramethyl-[1,1′-biphenyl]-2,6-diamine, and the molecular formula is C28H41N2P, Safety of 2′-(Dicyclohexylphosphino)-N2,N2,N6,N6-tetramethyl-[1,1′-biphenyl]-2,6-diamine.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Thauvin, Cedric published the artcileMicrowave-assisted synthesis of self-assembling bi-functionalizable amphiphilic diblock copolymers, Application In Synthesis of 1353016-70-2, the publication is Journal of Drug Delivery Science and Technology (2021), 102255, database is CAplus.

Active biodegradable polymeric materials are a key area of investigation to develop new imaging and treatment modalities. In this study, we sought to develop tailor-made bi-functionalizable amphiphilic diblock copolymers (BFACs) bearing different reactive groups (e.g., azide, alkyne, maleimide, biotin) on both ends. Designed with a linear backbone constituted of poly (lactic acid), a hydrophobic biodegradable polyester, and poly (ethylene glycol), a hydrophilic biocompatible polymer, BFACs can self-assemble in aqueous media. They are synthesized using a straightforward two-step process: a microwave-assisted ring-opening polymerization followed by a Steglich esterification. BFACs are able to keep their micellar state after the functionalization of their reactive groups via covalent linking or strong interactions with different fluorescent dyes. Interestingly, formation of BFACs-based micelles and their double labeling can be performed in one step. Finally, the uptake of functionalized BFACs-based micelles in the cytoplasmic compartments of MCF-7 cells is observed, thereby illustrating the potential of BFACs to be an easy-to-use tool towards fast development of nanoconstructs for therapy, imaging or theranostics.

Journal of Drug Delivery Science and Technology published new progress about 1353016-70-2. 1353016-70-2 belongs to quinuclidine, auxiliary class Other Aromatic Heterocyclic,Carboxylic acid,Amide,Inhibitor,Inhibitor, name is Dbco-acid, and the molecular formula is C6H11BF3KO, Application In Synthesis of 1353016-70-2.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Beyer, Frederick L. published the artcileApplication of the small-angle scattering invariant to morphological behavior in ballistic materials, Recommanded Product: 4,4-Diaminodicyclohexyl methane, the publication is Journal of Applied Polymer Science (2021), 138(21), 50478, database is CAplus.

The small-angle scattering invariant provides a useful tool for quantifying nanoscale morphol. features in two-phase materials, when scattering data of sufficient quality and angular range are available. In this work, an invariant anal. has been performed on small-angle X-ray scattering data for a series of epoxy-amines previously found to have relatively high-energy absorption (KE50) in ballistic impact tests. The improved performance was hypothesized to be a result of the formation of an ill-defined two-phase morphol., observed but not quantified using transmission electron microscopy. In this anal., the ballistic performance and the scattering invariant were found to be strongly correlated, with a Pearson’s linear correlation coefficient of 0.94. Facile anal. enabled by a custom software procedure suggests that this previously difficult anal. may be more broadly useful, even in high throughput applications.

Journal of Applied Polymer Science published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C13H26N2, Recommanded Product: 4,4-Diaminodicyclohexyl methane.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Zhou, Zhuxin published the artcileAchieving white-light emission in a single-component polymer with halogen-assisted interaction, Application of 4,4-Diaminodicyclohexyl methane, the publication is Science China: Chemistry (2021), 64(3), 467-477, database is CAplus.

White-light emitting (WLE) polymers have attracted continuous attention for their promising applications in solid-state lighting, flexible display and related fields. However, achieving dual-emission and pure white-light emission in a single-component polymer is still challenging. In this study, a brominated single-component polymer BrOD-TFB was designed and synthesized, which shows dual-emission and white light emission properties in solution and room-temperature phosphorescence (RTP) in thin films. The dual-emission properties can be tuned by concentration, solvent polarity, and excitation energy. Spectral anal. and theor. calculations reveal that the origin of the high-energy emission band (HEB) is intramol. charge transfer (ICT) along the polymer chain, while the low-energy emission band (LEB) originates from the excited-state related to the intra-chain and inter-chain C-Br···π interactions as demonstrated by the single-crystal structure of the model compound Appropriate control of the formation and the destruction of the halogen-assisted interactions can initiate white-light emission in the single-component polymer. More interestingly, by dispersing BrOD-TFB (0.1 wt%) in a non-emissive, colorless and transparent polymer, the characteristics of this white-light emission can be fully demonstrated while exhibiting unexpected RTP properties, with photoluminescence quantum efficiency (φ_PL) of up to 23% and CIE coordinates of (0.32, 0.32).

Science China: Chemistry published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C10H9NO, Application of 4,4-Diaminodicyclohexyl methane.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Kirsch, Janelle K. published the artcilePd-Catalyzed Alkene Carboheteroarylation Reactions for the Synthesis of 3-Cyclopentylindole Derivatives, Related Products of quinuclidine, the publication is Journal of Organic Chemistry (2018), 83(21), 13568-13573, database is CAplus and MEDLINE.

The Pd-catalyzed alkene carboheteroarylation of aryl and alkenyl triflate electrophiles bearing pendant alkenes with heteroaromatic nucleophiles affords substituted carbocycles with 3-indolyl or 3-pyrrolyl groups. The products are obtained in moderate to good yields, and the use of alkenyl triflate substrates produces products with high diastereoselectivities. The transformation is believed to proceed via a Friedel-Crafts-like reaction between the heteroaromatic nucleophile and an intermediate electrophilic palladium complex.

Journal of Organic Chemistry published new progress about 1160556-64-8. 1160556-64-8 belongs to quinuclidine, auxiliary class Mono-phosphine Ligands, name is 2′-(Dicyclohexylphosphino)-N2,N2,N6,N6-tetramethyl-[1,1′-biphenyl]-2,6-diamine, and the molecular formula is C28H41N2P, Related Products of quinuclidine.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Asemani, H. R. published the artcileDual-curable coatings obtained from multi-functional non-isocyanate polyurethane oligomers, Related Products of quinuclidine, the publication is Journal of Coatings Technology and Research, database is CAplus.

The growing concerns and impending regulations on the usage of monomeric isocyanates in the production of polyurethane resins have led to the introduction of alternative non-isocyanate polyurethane (NIPU) systems. Although two-component NIPU coatings based on the reaction of cyclic carbonates and aliphatic amines have emerged as a promising option, they are still associated with two significant drawbacks: lower crosslinking densities due to reduced functionality of the oligomers and low ambient-temperature reactivity. This study reports the utilization of a hybrid approach to address these drawbacks. Amine-functional NIPU oligomers (NI-PUPA) were synthesized by the reaction of cycloaliphatic amine functional compounds and multi-functional cyclic carbonates in an excess amine molar ratio. After mixing the NI-PUPAs with (3-glycidyloxypropyl) trimethoxysilane (GPTMS), a dual-curable coating could be achieved by ambient curing of amines and epoxies and moisture curing of alkoxy silanes. A comparative exptl. design was implemented to evaluate the effect of an addnl. curing mechanism. The results revealed that the addnl. moisture curing led to faster ambient curing, faster development of properties, enhanced flexibility even at higher crosslinking densities, and better corrosion resistance. Such advancement could facilitate the future implementation of NIPUs in high-performance ambient-curing coating applications.

Journal of Coatings Technology and Research published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C13H26N2, Related Products of quinuclidine.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Ding, Wen published the artcileMolecular-oxygen-promoted Cu-catalyzed oxidative direct amidation of nonactivated carboxylic acids with azoles, Computed Properties of 20029-52-1, the publication is Beilstein Journal of Organic Chemistry (2015), 2158-2165, database is CAplus and MEDLINE.

A copper-catalyzed oxidative direct formation of amides from nonactivated carboxylic acids and azoles with dioxygen as an activating reagent was reported. The azole amides were produced in good to excellent yields with a broad substrate scope. The mechanistic studies revealed that oxygen played an essential role in the success of the amidation reactions with copper peroxycarboxylate as the key intermediate. Transamidation occurs smoothly between azole amide and a variety of amines.

Beilstein Journal of Organic Chemistry published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C13H16O2, Computed Properties of 20029-52-1.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Ali, Imran published the artcileSynthesis, characterization, simulation, DNA binding and anticancer activities of Co(II), Cu(II), Ni(II) and Zn(II) complexes of a Schiff base containing o-hydroxyl group nitrogen ligand, Application of 4,4-Diaminodicyclohexyl methane, the publication is Inorganic Chemistry Communications (2020), 108004, database is CAplus.

New Schiff’s base (ligand) and its copper, cobalt, nickel and zinc metal ion complexes were synthesized with a good yield of 86 to 68.9%. and characterized by various anal. techniques. The spectral data confirms the formation of the compounds The ligand and the metal complexes were screened for anticancer activities with A549 and H1299 lung cancer lines. The results indicated that the zinc metal ion complex was the most active with 83.60 and 88.52% inhibitions for A549 and H1299 lung cancer lines at 20 mM concentration Besides, DNA binding study confirmed good binding constants (0.94 x 105-2.31 x 105) with a maximum of zinc metal ion complex (2.31 x 105); confirming the anticancer activities results. The docking study also confirmed that the reported mols. interacted with DNA strongly by hydrogen bonding and hydrostatic interactions with -4.6 kCal/mol as binding energy. It was also observed that the reported mols. preferred minor grooves of DNA for interactions. The excellent anticancer activities of metal complexes confirmed that these complexes may be the future lung cancer medication.

Inorganic Chemistry Communications published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C13H26N2, Application of 4,4-Diaminodicyclohexyl methane.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider