Park, Byeongyeon’s team published research in Bioorganic & Medicinal Chemistry Letters in 27 | CAS: 20029-52-1

Bioorganic & Medicinal Chemistry Letters published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C13H16O2, HPLC of Formula: 20029-52-1.

Park, Byeongyeon published the artcile3,4-Dihydroquinazoline derivatives inhibit the activities of cholinesterase enzymes, HPLC of Formula: 20029-52-1, the publication is Bioorganic & Medicinal Chemistry Letters (2017), 27(5), 1179-1185, database is CAplus and MEDLINE.

A series of 3,4-dihydroquinazoline derivatives consisting of the selected compounds from our chem. library on the diversity basis and the new synthetic compounds were in vitro tested for their inhibitory activities for both acetylcholinesterase (AChE, from elec. eel) and butyrylcholinesterase (BChE, from equine serum) enzymes. It was discovered that most of the compounds displayed weak AChE and strong BuChE inhibitory activities. In particular, compound 8b and 8d were the most active compounds in the series against BChE with IC50 values of 45 nM and 62 nM, as well as 146- and 161-fold higher affinity to BChE, resp. To understand the excellent activity of these compounds, mol. docking simulations were performed to get better insights into the mechanism of binding of 3,4-dihydroquinazoline derivatives As expected, compound 8b and 8d bind to both catalytic anionic site (CAS) and peripheral site (PS) of BChE with better interaction energy values than AChE, in agreement with our exptl. data. Furthermore, the non-competitive/mixed-type inhibitions of both compounds further confirmed their dual binding nature in kinetic studies.

Bioorganic & Medicinal Chemistry Letters published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C13H16O2, HPLC of Formula: 20029-52-1.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider