Saito, Fumito published the artcileCritical Evaluation and Rate Constants of Chemoselective Ligation Reactions for Stoichiometric Conjugations in Water, Quality Control of 1353016-70-2, the publication is ACS Chemical Biology (2015), 10(4), 1026-1033, database is CAplus and MEDLINE.
Chemoselective ligation reactions have contributed immensely to the development of organic synthesis and chem. biol. However, the ligation of stoichiometric amounts of large mols. for applications such as protein-protein conjugates is still challenging. Conjugation reactions need to be fast enough to proceed under dilute conditions and chemoselective in the presence of unprotected functional groups; the starting materials and products must be stable under the reaction conditions. To compare known ligation reactions for their suitability under these conditions, we determined the second-order rate constants of ligation reactions using peptide substrates with unprotected functional groups. The reaction conditions, the chemoselectivity of the reactions, and the stability of the starting materials and products were carefully evaluated. In some cases, the stability could be improved by modifying the substrate structure. These data obtained under the ligation conditions provide a useful guide to choose an appropriate ligation reaction for synthesis of large mols. by covalent ligation reactions of unprotected substrates in water.
ACS Chemical Biology published new progress about 1353016-70-2. 1353016-70-2 belongs to quinuclidine, auxiliary class Other Aromatic Heterocyclic,Carboxylic acid,Amide,Inhibitor,Inhibitor, name is Dbco-acid, and the molecular formula is C19H15NO3, Quality Control of 1353016-70-2.
Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider