Day: November 25, 2022

Cheng, Ho Fung published the artcileElectron-Equivalent Valency through Molecularly Well-Defined Multivalent DNA, Related Products of quinuclidine, the publication is Journal of the American Chemical Society (2021), 143(4), 1752-1757, database is CAplus and MEDLINE.

Oligonucleotide-functionalized nanoparticles (NPs), also known as “programmable atom equivalent” (PAEs), have emerged as a class of versatile building blocks for generating colloidal crystals with tailorable structures and properties. Recent studies have shown that, at small size and low DNA grafting d., PAEs can also behave as “electron equivalent” (EEs), roaming through and stabilizing a complementary PAE sublattice. However, it has been challenging to obtain a detailed understanding of EE-PAE interactions and the underlying colloidal metallicity because there is inherent polydispersity in the number of DNA strands on the surfaces of these NPs; thus, the structural uniformity and tailorability of NP-based EEs are somewhat limited. Herein, we report a strategy for synthesizing colloidal crystals where the EEs are templated by small mols., instead of NPs, and functionalized with a precise number of DNA strands. When these molecularly precise EEs are assembled with complementary NP-based PAEs, X-ray scattering and electron microscopy reveal the formation of three distinct “metallic” phases. Importantly, we show that the thermal stability of these crystals is dependent on the number of sticky ends per EE, while lattice symmetry is controlled by the number and orientation of EE sticky ends on the PAEs. Taken together, this work introduces the notion that, unlike conventional electrons, EEs that are mol. in origin can have a defined valency that can be used to influence and guide specific phase formation.

Journal of the American Chemical Society published new progress about 1353016-70-2. 1353016-70-2 belongs to quinuclidine, auxiliary class Other Aromatic Heterocyclic,Carboxylic acid,Amide,Inhibitor,Inhibitor, name is Dbco-acid, and the molecular formula is C19H15NO3, Related Products of quinuclidine.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Wang, Yaxin published the artcileVisible-Light-Promoted Site-Specific and Diverse Functionalization of a C(sp³)-C(sp³) Bond Adjacent to an Arene, Synthetic Route of 20029-52-1, the publication is ACS Catalysis (2020), 10(12), 6603-6612, database is CAplus.

A strategy for inert C-C bond functionalization is reported. Site-specific cleavage and functionalization of saturated C(sp3)-C(sp3) bond via a visible-light-induced radical process was achieved. The general features of this reaction are: 1-Both linear and cyclic C(sp3)-C(sp3) bonds with a vicinal arene can be specifically functionalized; 2-One carbon is converted into ketone, and the another can be tunably converted into nitrile, peroxide or halide; 3-The typical conditions includes: 1.0 mol% Ru(bpy)3Cl2, 1.0 or 5.0 equiv of Zhdankin reagent, white CFL (24 W), open flask and room temperature These reactions offer a powerful tool to modify carbon skeletons that are intractable by conventional methods. Good selectivity and functional group tolerance, together with mild and open air conditions make these transformations valuable and attractive.

ACS Catalysis published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C9H10O3S, Synthetic Route of 20029-52-1.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Hui, Xiang published the artcileHighly efficient synthesis of novel bio-based pentamethylene dicarbamate via carbonylation of pentanediamine with ethyl carbamate over well-defined titanium oxide catalysts, Category: quinuclidine, the publication is Catalysis Science & Technology (2022), 12(7), 2315-2327, database is CAplus.

Carbonylation of pentanediamine (PDA) is a green and effective route for the synthesis of pentamethylene dicarbamate (PDC), an important intermediate compound for the preparation of polyurethanes (PUs) and other chems. In this work, TiO₂-101 and TiO₂-110 catalysts, with preferential exposure of (101) and (110) facets, resp., were prepared and studied for the carbonylation of diamines with Et carbamate (EC) to give dicarbamates, e.g., EtO₂C(CH₂)₇NHCO₂Et and I. The catalysts were characterized by various techniques, including XRD, BET, SEM, TEM, XPS, NH₃-TPD and in situ FTIR. The characterization results indicated that TiO₂ catalysts with exposed (110) and (101) facets were synthesized successfully. The overall results suggested that the (101) facets on the TiO₂ surface provide high amounts of surface Lewis acid sites that played a pivotal role in PDC formation, which gave a conversion and yield both up to 99% under optimized conditions. In situ FTIR spectroscopy clearly revealed that polyurea as an intermediate was formed in the reaction and subsequently converted to PDC catalyzed by the TiO₂ catalyst. Furthermore, the DFT results showed that the conversion of polyurea to PDC over the (101) facets was more prone to occur than the (110) facets due to the lower reaction energy barrier. In addition, the TiO₂-101 catalyst displayed excellent stability without an obvious activity decline after five cycles.

Catalysis Science & Technology published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C13H26N2, Category: quinuclidine.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Akinbobuyi, Babatope published the artcileSynthesis and immunostimulatory activity of substituted TLR7 agonists, Application In Synthesis of 1353016-70-2, the publication is Bioorganic & Medicinal Chemistry Letters (2016), 26(17), 4246-4249, database is CAplus and MEDLINE.

Fifteen new substituted 9-benzyladenines were synthesized as potential TLR7 agonists. These compounds, along with 9 previously reported compounds, were analyzed for TLR7 activity and for the selective stimulation of B cell proliferation. Several functionalized derivatives exhibit significant activity, suggesting their potential for use as vaccine adjuvants.

Bioorganic & Medicinal Chemistry Letters published new progress about 1353016-70-2. 1353016-70-2 belongs to quinuclidine, auxiliary class Other Aromatic Heterocyclic,Carboxylic acid,Amide,Inhibitor,Inhibitor, name is Dbco-acid, and the molecular formula is C19H15NO3, Application In Synthesis of 1353016-70-2.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Yang, Ya-Jun published the artcileDesign, synthesis and biological evaluation of dipeptides as novel non-covalent 20S proteasome inhibitors, Recommanded Product: 4-Cyclohexylbenzoic acid, the publication is Journal of Asian Natural Products Research (2021), 23(5), 436-451, database is CAplus and MEDLINE.

Based on the interaction modes of the natural 20S proteasome inhibitors , we have previously discovered a dipeptide . To explore the SAR around compound , we designed and synthesized a series of dipeptides () with a fragment-based strategy. Among them, nine compounds showed significant inhibitory activities against the chymotrypsin-like activity of human 20S proteasome with IC₅₀ values at the submicromolar level, which were comparable or even superior to the parent compound Meanwhile, they displayed no significant inhibition against trypsin-like and caspase-like activities of 20S proteasome. The results suggested the feasibility to design dipeptides as novel and potent 20S proteasome inhibitors.

Journal of Asian Natural Products Research published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C12H14IN, Recommanded Product: 4-Cyclohexylbenzoic acid.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Li, Jian-Jun published the artcileCu-Catalyzed C-H Alkenylation of Benzoic Acid and Acrylic Acid Derivatives with Vinyl Boronates, Application of 4-Cyclohexylbenzoic acid, the publication is Organic Letters (2020), 22(12), 4692-4696, database is CAplus and MEDLINE.

An efficient Cu-catalyzed C-H alkenylation with acyclic and cyclic vinyl boronates was realized for the first time under mild conditions. The scope of the vinyl borons and the compatibility with functional groups including heterocycles are superior than Pd-catalyzed C-H coupling with vinyl borons, providing a reliable access to multisubstituted alkenes and dienes. Subsequent hydrogenation of the product from the internal vinyl borons will lead to installation of secondary alkyls.

Organic Letters published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C13H16O2, Application of 4-Cyclohexylbenzoic acid.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Lai, Zhencheng published the artcileRedox Cyclization of Amides and Sulfonamides with Nitrous Oxide for Direct Synthesis of Heterocycles, Application In Synthesis of 20029-52-1, the publication is Organic Letters (2020), 22(5), 2017-2021, database is CAplus and MEDLINE.

A redox cyclization of amides R¹C(O)NHR² (R¹ = C₆H₅, 1-naphthyl, 5-methylthiophen-2-yl, etc.; R² = Me, t-Bu, cyclopropyl, etc.) and sulfonamides 4-R³C₆H₄S(O)₂NHR⁴ (R³ = H, Me, t-Bu, Ph, OMe, Cl; R⁴ = Me, t-Bu, cyclopropyl, etc.) with nitrous oxide (N₂O) for the direct synthesis of heterocycles, e.g., I has been described. Various amides and sulfonamides could undergo directed ortho metalation (DoM) by treatment with BuLi, and the lithium intermediate could be trapped by N₂O gas to achieve redox cyclization. N₂O serves as an N-atom donor to mediate the intramol. coupling of lithium species toward heterocycle formation with free external oxidant. This protocol offers a direct synthesis of heterocycles with features of readily available starting materials, simple operation, and a broad substrate scope.

Organic Letters published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C13H16O2, Application In Synthesis of 20029-52-1.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Kumar, Amit published the artcileHydrogenative Depolymerization of Nylons, Synthetic Route of 1761-71-3, the publication is Journal of the American Chemical Society (2020), 142(33), 14267-14275, database is CAplus and MEDLINE.

The widespread crisis of plastic pollution demands discovery of new and sustainable approaches to degrade robust plastics such as nylons. Using a green and sustainable approach based on hydrogenation, in the presence of a ruthenium pincer catalyst at 150 oC and 70 bar H2, we report here the first example of hydrogenative depolymerization of conventional, widely used nylons, and polyamides in general. Under the same catalytic conditions, we also demonstrate the hydrogenation of a polyurethane to produce diol, diamine and methanol. Addnl., we demonstrate an example where monomers (and oligomers) obtained from the hydrogenation process can be dehydrogenated back to a poly(oligo)amide of approx. similar mol. weight, thus completing a closed loop cycle for recycling of poly-amides. Based on the exptl. and DFT studies, we propose a catalytic cycle for the process that is facilitated by metal-ligand cooperativity. Overall, this unprecedented transformation, albeit at the proof of concept level, offers a new approach towards a cleaner route to recycling nylons.

Journal of the American Chemical Society published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C13H26N2, Synthetic Route of 1761-71-3.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Park, Nathaniel H. published the artcileDesign of New Ligands for the Palladium-Catalyzed Arylation of α-Branched Secondary Amines, SDS of cas: 1160556-64-8, the publication is Angewandte Chemie, International Edition (2015), 54(28), 8259-8262, database is CAplus and MEDLINE.

In Pd-catalyzed C-N cross-coupling reactions, α-branched secondary amines are difficult coupling partners and the desired products are often produced in low yields. In order to provide a robust method for accessing N-aryl α-branched tertiary amines, new catalysts have been designed to suppress undesired side reactions often encountered when these amine nucleophiles are used. These advances enabled the arylation of a wide array of sterically encumbered amines, highlighting the importance of rational ligand design in facilitating challenging Pd-catalyzed cross-coupling reactions.

Angewandte Chemie, International Edition published new progress about 1160556-64-8. 1160556-64-8 belongs to quinuclidine, auxiliary class Mono-phosphine Ligands, name is 2′-(Dicyclohexylphosphino)-N2,N2,N6,N6-tetramethyl-[1,1′-biphenyl]-2,6-diamine, and the molecular formula is C28H41N2P, SDS of cas: 1160556-64-8.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Chadwick, Ryan C. published the artcileScalable synthesis of strained cyclooctyne derivatives, Formula: C19H15NO3, the publication is Synthesis (2014), 46(5), 669-677, 9 pp., database is CAplus.

Modifications to the Popik synthesis of azadibenzocyclooctyne (DIBAC) derivatives are described, which avoids tedious purifications and dramatically improves the yield. A new and analogous route to biarylazacyclooctynone (BARAC) through an amide disconnection was also attempted. The BARAC derivatives prepared were found to be unstable under the conditions employed, undergoing a known rearrangement. Finally, the synthesis of a difluoro-DIBAC derivative with a second-order rate constant intermediate between DIBAC and BARAC derivatives (0.50 M-1) is described. While more difficult to synthesize, this mol. was found to be considerably more stable than any BARAC derivatives that were prepared

Synthesis published new progress about 1353016-70-2. 1353016-70-2 belongs to quinuclidine, auxiliary class Other Aromatic Heterocyclic,Carboxylic acid,Amide,Inhibitor,Inhibitor, name is Dbco-acid, and the molecular formula is C19H15NO3, Formula: C19H15NO3.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider