McNelles, Stuart A.’s team published research in Macromolecules (Washington, DC, United States) in 51 | CAS: 1353016-70-2

Macromolecules (Washington, DC, United States) published new progress about 1353016-70-2. 1353016-70-2 belongs to quinuclidine, auxiliary class Other Aromatic Heterocyclic,Carboxylic acid,Amide,Inhibitor,Inhibitor, name is Dbco-acid, and the molecular formula is C19H15NO3, Recommanded Product: Dbco-acid.

McNelles, Stuart A. published the artcileQuantitative Characterization of the Molecular Dimensions of Flexible Dendritic Macromolecules in Solution by Pyrene Excimer Fluorescence, Recommanded Product: Dbco-acid, the publication is Macromolecules (Washington, DC, United States) (2018), 51(4), 1586-1590, database is CAplus.

Eight pyrene labeled dendrons (PyLDs) were prepared with a polyester backbone of bis(hydroxymethyl)propionic acid and the monomer and excimer fluorescence decays of the PyLDs were acquired and fitted according to the recently introduced model free anal. (MFA). The average rate constant of pyrene excimer formation <k> retrieved from the MFA of the decays was found to scale as (2N-1)×l3/<LPy2>1.5 where N represents the number of ground-state pyrene labels in a dendrimer where one of the pyrene is already excited, l is the average bond length, and <LPy2> is the average squared end-to-end distance between every two pyrene labels. The remarkable agreement found between these two quantities, namely <k> and (2N-1)×l3/<LPy2>1.5 which were determined exptl. and math., resp., provides strong support to the notion that pyrene excimer fluorescence (PEF) responds to <LPy2> for pyrene labels attached to macromol. constructs. In turn, <LPy2>0.5 can be used as a measure of the dimension of the macromol. object onto which the pyrene labels are covalently attached. Since (2N-1)/<LPy2>1.5 is the local concentration of ground-state pyrenes in the PyLD, the ratio <k>/[(2N-1)/<LPy2>1.5] yields the bimol. rate constant for excimer formation kdiff which was found to equal 5.0 (±0.6)×109 s-1 for the PyLDs. Consequently, this study demonstrates that PEF applied to macromols. yields a quant. measure of their dimension and internal dynamics and since the rate constant of excimer formation is not distance-dependent, provides a much simpler math. alternative to experiments based on fluorescence resonance energy transfer (FRET).

Macromolecules (Washington, DC, United States) published new progress about 1353016-70-2. 1353016-70-2 belongs to quinuclidine, auxiliary class Other Aromatic Heterocyclic,Carboxylic acid,Amide,Inhibitor,Inhibitor, name is Dbco-acid, and the molecular formula is C19H15NO3, Recommanded Product: Dbco-acid.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider