Costanzo, Michael J. published the artcilePotent, nonpeptide inhibitors of human mast cell tryptase. Investigation of the carboxamide portion of spirocyclic piperidine amides, Quality Control of 20029-52-1, the publication is Letters in Drug Design & Discovery (2008), 5(2), 116-121, database is CAplus.
The authors have explored a series of spirocyclic piperidine amide derivatives with respect to the N-acyl portion (viz. 6) for inhibition of tryptase. Thus, the authors identified analogs (I and II) as potent tryptase inhibitors (IC50 < 10 nM) with excellent selectivity vs. trypsin. Four other interesting compounds in this chem. series had IC50 = 10-20 nM. X-ray cocrystal structures of tryptase complexes with spirocyclic piperidine amides are reported.
Letters in Drug Design & Discovery published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C13H16O2, Quality Control of 20029-52-1.
Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider