Month: November 2022

Meyer, Christopher S. published the artcileMesoscale modeling of ballistic impact experiments on a single layer of plain weave composite, Name: 4,4-Diaminodicyclohexyl methane, the publication is Composites, Part B: Engineering (2022), 109753, database is CAplus.

To gain fundamental understanding of energy absorbing mechanisms during high velocity impact of plain weave S-2 glass/epoxy composites, single layer composites are ballistically tested and modeled. To avoid boundary condition effects, targets were 0.6 m by 0.6 m with free boundaries. Targets were perforated by 17 grain, 0.22 caliber fragment simulating projectiles. Experiments focused on determining ballistic limit velocity and the associated damage modes. The experiments were simulated with a continuum finite element model with effective plain weave properties that predicted the ballistic limit velocity with 6% error. A mesoscale model that incorporates the woven fabric architecture and lower length scale energy absorbing mechanisms was also developed. The mesoscale model includes accurate geometry and fiber volume fraction, rate-dependent matrix behavior, and important damage mechanisms including tow-tow delamination, tow pullout and frictional sliding. The mesoscale model predicted ballistic limit velocity with 1% error and more accurately predicts the deformation modes during ballistic impact and penetration than the continuum modeling approach. The mesoscale model indicated two phases of penetration, the first dominated by momentum transfer and the second dominated by tow tension and pullout. In a materials-by-design framework, the mesoscale model was used to quantify energy dissipation and identify important damage mechanisms that could be optimized to provide improved ballistic penetration resistance.

Composites, Part B: Engineering published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C13H26N2, Name: 4,4-Diaminodicyclohexyl methane.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Saito, Fumito published the artcileCritical Evaluation and Rate Constants of Chemoselective Ligation Reactions for Stoichiometric Conjugations in Water, Quality Control of 1353016-70-2, the publication is ACS Chemical Biology (2015), 10(4), 1026-1033, database is CAplus and MEDLINE.

Chemoselective ligation reactions have contributed immensely to the development of organic synthesis and chem. biol. However, the ligation of stoichiometric amounts of large mols. for applications such as protein-protein conjugates is still challenging. Conjugation reactions need to be fast enough to proceed under dilute conditions and chemoselective in the presence of unprotected functional groups; the starting materials and products must be stable under the reaction conditions. To compare known ligation reactions for their suitability under these conditions, we determined the second-order rate constants of ligation reactions using peptide substrates with unprotected functional groups. The reaction conditions, the chemoselectivity of the reactions, and the stability of the starting materials and products were carefully evaluated. In some cases, the stability could be improved by modifying the substrate structure. These data obtained under the ligation conditions provide a useful guide to choose an appropriate ligation reaction for synthesis of large mols. by covalent ligation reactions of unprotected substrates in water.

ACS Chemical Biology published new progress about 1353016-70-2. 1353016-70-2 belongs to quinuclidine, auxiliary class Other Aromatic Heterocyclic,Carboxylic acid,Amide,Inhibitor,Inhibitor, name is Dbco-acid, and the molecular formula is C19H15NO3, Quality Control of 1353016-70-2.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Masutani, Yusuke published the artcileShape memory property of carbon fiber / epoxy resin composite materials, HPLC of Formula: 1761-71-3, the publication is Zairyo (2021), 70(1), 25-30, database is CAplus.

The authors investigated an effect of carbon fiber on shape memory property of carbon fiber / shape memory polymer (epoxy resin) composites by using dynamic mech. anal. (DMA), shape memory test, and mech. constitutive model. As a result of DMA, the storage modulus (E’) of the composite material (CF/EP) was improved by CF component, as compared with that of the pure epoxy resin (pure EP). Especially, E’ at rubbery region was remarkably increased with two decades. From the results of shape memory test, CF/EP showed good shape recovery behavior as well as pure EP. Contrary, the shape fixity ratio of CF/EP was lower than that of pure EP. This is because that the difference in E’ below / above the glass transition temperature (T_g) of CF/EP became smaller (less than one decade) than pure EP (two decades). In addition, the shape recovery of CF/EP started at lower temperature than T_g, although the recovery of pure EP showed around T_g. In order to examine the shape recovery behavior of CF/EP, the authors compared the viscoelastic properties of three samples, pure EP, CF layer and the composite. As a result, the CF layer had higher E’ than CF/EP, and no significant change in E’ occurred around T_g. From the results, the authors speculated that the CF layer acted as a shape recovery component for the composite material. Furthermore, the authors proposed a mech. constitutive model, in which the CF layer was assumed as the recover component, to qual. explain the shape recovery behavior of CF/EP composite. The simulated result by the constitutive model reproduced the trend of anomalous shape recovery behavior below T_g of CF/EP.

Zairyo published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C13H26N2, HPLC of Formula: 1761-71-3.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Tominaga, Ren published the artcileCo-continuous network polymers using epoxy monolith for the design of tough materials, COA of Formula: C13H26N2, the publication is Scientific Reports (2021), 11(1), 1431, database is CAplus and MEDLINE.

High-performance polymer materials that can exhibit distinguished mech. properties have been developed based on material design considering energy dissipation by sacrificial bond dissociation We now propose co-continuous network polymers (CNPs) for the design of tough polymer materials. CNP is a new composite material fabricated by filling the three-dimensionally continuous pores of a hard epoxy monolith with any cross-linked polymer having a low glass transition temperature (Tg). The structure and mech. properties of the CNPs containing epoxy resins, thiol-ene thermosets, and polyacrylates as the low-Tg components were investigated by differential scanning calorimetry, dynamic mech. anal., tensile tests as well as scanning electron microscopic observations and non-destructive 3D X-ray imaging in order to clarify a mechanism for exhibiting an excellent strength and toughness. It has been demonstrated that the mech. properties and fractural behavior of the CNPs significantly depend on the network structure of the filler polymers, and that a simultaneous high strength and toughness are achieved via the sacrificial fracture mechanism of epoxy-based hard materials with co-continuous network structures.

Scientific Reports published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C8H16O2, COA of Formula: C13H26N2.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

DeBergh, J. Robb published the artcileSynthesis of Aryl Sulfonamides via Palladium-Catalyzed Chlorosulfonylation of Arylboronic Acids, Formula: C28H41N2P, the publication is Journal of the American Chemical Society (2013), 135(29), 10638-10641, database is CAplus and MEDLINE.

A palladium-catalyzed method for the preparation of sulfonamides is described. The process exhibits significant functional group tolerance and allows for the preparation of a number of arylsulfonyl chlorides and sulfonamides under mild conditions. E.g., in presence of the Pd catalyst I (L = ligand II), reaction of PhOSO₂Cl with 4-methoxyphenylboronic acid, followed by reaction with morpholine, gave 95% sulfonamide III.

Journal of the American Chemical Society published new progress about 1160556-64-8. 1160556-64-8 belongs to quinuclidine, auxiliary class Mono-phosphine Ligands, name is 2′-(Dicyclohexylphosphino)-N2,N2,N6,N6-tetramethyl-[1,1′-biphenyl]-2,6-diamine, and the molecular formula is C28H41N2P, Formula: C28H41N2P.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Yang, Yang published the artcileHighly Selective Palladium-Catalyzed Cross-Coupling of Secondary Alkylzinc Reagents with Heteroaryl Halides, Synthetic Route of 1160556-64-8, the publication is Organic Letters (2014), 16(17), 4638-4641, database is CAplus and MEDLINE.

The highly selective palladium-catalyzed Negishi coupling of secondary alkylzinc reagents with heteroaryl halides is described [e.g., using a palladacycle precatalyst ligated by CPhos, 3-chlorobenzisothiazole was coupled with i-PrZnBr.LiCl to afford 3-isopropylbenzisothiazole in 78% yield (normal:rearranged ratio = 98:2)]. The development of a series of biarylphosphine ligands has led to the identification of an improved catalyst for the coupling of electron-deficient heterocyclic substrates. Preparation and characterization of oxidative addition complex (L)(Ar)PdBr provided insight into the unique reactivity of catalysts based on CPhos-type ligands in facilitating challenging reductive elimination processes.

Organic Letters published new progress about 1160556-64-8. 1160556-64-8 belongs to quinuclidine, auxiliary class Mono-phosphine Ligands, name is 2′-(Dicyclohexylphosphino)-N2,N2,N6,N6-tetramethyl-[1,1′-biphenyl]-2,6-diamine, and the molecular formula is C22H23ClN4, Synthetic Route of 1160556-64-8.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Neunhoeffer, Otto published the artcileTricyclohexylmethane series. II. Cyclohexylphenyl-substituted pinacols and pinacolones, Application of 4-Cyclohexylbenzoic acid, the publication is Justus Liebigs Annalen der Chemie (1936), 47-58, database is CAplus.

cf. C. A. 28, 3385.3. The action of cyclohexylmagnesium chloride (I) upon benzil gives only hydrobenzoin (quant. yield). The reaction of I and (CO₂Et)₂ (22 g.) gives 23 g. cyclohexylglyoxylic acid, b_0.5 90-100° (hydrazide, m. 199°), 22 g. Et dicyclohexylglycolate, b_0.5 123-3.5°, m. 70°, and 1.8 g. of 1,1,2-tricyclohexylethan-1-ol-2-one, m. 154°. Ph₂CHCO₂Et (II) does not react with I. Catalytic reduction of II gives Et dicyclohexylacetate, m. 88°, which also does not react with I. The Na compound of dicyclohexylphenylmethyl (III) and BzCl give only the dimer of III, m. 207°; PhCN gives triphenyltriazine, m. 230°. I and the acid Me ester of benzilic acid give 2-cyclohexyl-1-diphenylethan-1-ol-2-one, m. 112°. Catalytic reduction of benzopinacolone results in the absorption of 6 mol H₂ and the formation of 1,2-dicyclohexyl-1,1-diphenylethan-2-one (IV), m. 130°; oxidation gives Ph₂CO. Reduction of cyclohexyl Ph ketone with Zn and 50% H₂SO₄ gives a mixture of 2 forms of dicyclohexyldiphenylethylene glycol (V), m. 198° and 160°; with concentrated HCl and boiling AcOH there results IV. While IV is not reduced in the usual ways, cyclohexylmagnesium iodide gives dicyclohexyldiphenylethylene, m. 192°; BzO₂H gives the V m. 195-6°.

Justus Liebigs Annalen der Chemie published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C13H16O2, Application of 4-Cyclohexylbenzoic acid.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Baddam, Sudhakar Reddy published the artcileZinc triflate catalyzed synthesis of thioethers, Name: 2-(1-(Mercaptomethyl)cyclopropyl)acetic acid, the publication is Chemistry & Biology Interface (2014), 4(2), 131-136, 6 pp., database is CAplus.

Zinc triflate-catalyzed aralkylation of thiols using various substituted benzylic alcs. was developed for the synthesis of thioether (sulfide) derivatives This procedure presents a greener approach for the synthesis of sulfides.

Chemistry & Biology Interface published new progress about 162515-68-6. 162515-68-6 belongs to quinuclidine, auxiliary class Thiol,Carboxylic acid,Aliphatic cyclic hydrocarbon, name is 2-(1-(Mercaptomethyl)cyclopropyl)acetic acid, and the molecular formula is C6H10O2S, Name: 2-(1-(Mercaptomethyl)cyclopropyl)acetic acid.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Romero-Zuniga, Gabriela Yolotzin published the artcileEnhanced mechanical performance of a DGEBA epoxy resin-based shape memory polymer by introducing graphene oxide via covalent linking, Recommanded Product: 4,4-Diaminodicyclohexyl methane, the publication is Journal of Applied Polymer Science (2022), 139(2), 51467, database is CAplus.

Shape memory polymers (SMP) are prepared, via dual thiol-epoxy/thiol-ene reactions, from diglycidyl ether of bisphenol A (DGEBA), a trithiol (TMP), a tetraallyl amine (TAA), and small amounts (0.1-0.5 weight%) of graphene oxide either pristine (GO) or functionalized with methacrylate groups (GO_M). The incorporation of GO_M to the epoxy resin network permits a good load transfer, which is reflected in improved properties such as Young modulus (from 220 to 519 MPa), tensile strength (from 46.3 to 69.2 MPa), Izod impact strength (from 0.051 to 0.42 J/mm), torque (from 0.008 to 0.031 Nm), and glass transition temperature (from 75 to 105°C). Such improvement in properties is attributed to the incorporation of GO_M via covalent linking, which is a good strategy for improving polymer-particle interaction and particle dispersion. The epoxy-based SMP also show high storage modulus (up to 2.36 GPa) and high deformation capacity, which are reflected in good shape fixity (between 97% and 100%) and thermo-induced shape recovery (between 97% to 99.7%) behaviors in flexion mode tests.

Journal of Applied Polymer Science published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C13H26N2, Recommanded Product: 4,4-Diaminodicyclohexyl methane.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Park, Byeongyeon published the artcile3,4-Dihydroquinazoline derivatives inhibit the activities of cholinesterase enzymes, HPLC of Formula: 20029-52-1, the publication is Bioorganic & Medicinal Chemistry Letters (2017), 27(5), 1179-1185, database is CAplus and MEDLINE.

A series of 3,4-dihydroquinazoline derivatives consisting of the selected compounds from our chem. library on the diversity basis and the new synthetic compounds were in vitro tested for their inhibitory activities for both acetylcholinesterase (AChE, from elec. eel) and butyrylcholinesterase (BChE, from equine serum) enzymes. It was discovered that most of the compounds displayed weak AChE and strong BuChE inhibitory activities. In particular, compound 8b and 8d were the most active compounds in the series against BChE with IC₅₀ values of 45 nM and 62 nM, as well as 146- and 161-fold higher affinity to BChE, resp. To understand the excellent activity of these compounds, mol. docking simulations were performed to get better insights into the mechanism of binding of 3,4-dihydroquinazoline derivatives As expected, compound 8b and 8d bind to both catalytic anionic site (CAS) and peripheral site (PS) of BChE with better interaction energy values than AChE, in agreement with our exptl. data. Furthermore, the non-competitive/mixed-type inhibitions of both compounds further confirmed their dual binding nature in kinetic studies.

Bioorganic & Medicinal Chemistry Letters published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C13H16O2, HPLC of Formula: 20029-52-1.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider