Month: December 2022

Gan, Minfeng published the artcilePrecise in-situ release of microRNA from an injectable hydrogel induces bone regeneration, Quality Control of 1353016-70-2, the publication is Acta Biomaterialia (2021), 289-303, database is CAplus and MEDLINE.

Critical bone defects are a common yet challenging orthopedic problem. Tissue engineering is an emerging and promising strategy for bone regeneration in large-scale bone defects. The precise on-demand release of osteogenic factors is critical for controlling the osteogenic differentiation of seed cells with the support of appropriate three dimensional scaffolds. However, most of the effective osteogenic factors are biomacromols. with release behaviors that are difficult to control. Here, the cholesterol-modified non-coding microRNA Chol-miR-26a was used to promote the osteogenic differentiation of human mesenchymal stem cells (hMSCs). Chol-miR-26a was conjugated to an injectable poly(ethylene glycol) (PEG) hydrogel through an UV-cleavable ester bond. The injectable PEG hydrogel was formed by a copper-free click reaction between the terminal azide groups of 8-armed PEG and dibenzocyclooctyne-biofunctionalized PEG, into which UV-cleavable Chol-miR-26a was simultaneously conjugated via a Michael addition reaction. Upon UV irradiation, Gel-c-miR-26a (ML^Caged) released Chol-c-miR-26a selectively and exhibited significantly improved efficacy in bone regeneration compared to the hydrogel without UV irradiation and UV-uncleavable ML^Control. MLCaged significantly enhanced alk. phosphatase activity and promoted calcium nodule deposition in vitro and repaired critical skull defects in a rat animal model, demonstrating that injectable implantation with the precise release of osteogenic factors has the potential to repair large-scale bone defects in clin. practice. Provide a novel and practical strategy via hydrogel for efficient delivery and precisely controlled release of miRNAs into bone defect sites. The hydrogel is formed by polyethylene glycol (PEG), which is crosslinked by ′clickâ€?reaction. Cholesterol-modified miR-26a loading on the hydrogel is covalently patterned onto the fibers of hydrogel through a UV light-cleavable linker, which prevents undesired release of miRNA. This hydrogel could realize the controlled release of miRNA under light regulation both in vitro and in vivo, thus realize bone regeneration.

Acta Biomaterialia published new progress about 1353016-70-2. 1353016-70-2 belongs to quinuclidine, auxiliary class Other Aromatic Heterocyclic,Carboxylic acid,Amide,Inhibitor,Inhibitor, name is Dbco-acid, and the molecular formula is C19H15NO3, Quality Control of 1353016-70-2.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Zhao, Changchun published the artcileInterfacial combination of Ti₃C₂T_x MXene with waterborne epoxy anticorrosive coating, Safety of 4,4-Diaminodicyclohexyl methane, the publication is Applied Surface Science (2022), 150894, database is CAplus.

Interfacial combination of two-dimensional material composite coatings is one of the main factors affecting anti-corrosion performance of coatings. The surface of MXene are usually covered with active groups such as F, O, OH, etc. However, the interactions between active groups and epoxy mols. are still unclear. Here in, the adsorption stability and chem. bond types of Ti₃C₂Tx/epoxy structures with different surface groups were investigated by first-principles calculations The waterborne Ti₃C₂Tx/epoxy composite coatings were prepared by liquid phase blending method. The micro-structures, anticorrosion performance and compactness of the coatings were studied. Based on the theor. calculations, Ti₃C₂Tx shows excellent adsorption stability with epoxy mols., and the Ti₃C₂Tx with OH groups exhibited the best adsorption stability due to the formation of covalent bonds between OH groups and the epoxy groups (or benzene structures). The exptl. results show that, Ti₃C₂Tx nanosheets can disperse uniformly in the coating prepared by the liquid phase blending method. The micro-pores in composite coatings are improved, and the impedance modulus is 2 orders of magnitude much higher than that of pure epoxy coating. In this work, the studies of the adsorption behavior of Ti₃C₂Tx MXene to epoxy groups and benzene structures provide a reliable basis for the subsequent targeted regulation of the interaction between them.

Applied Surface Science published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C10H11FN2O2S, Safety of 4,4-Diaminodicyclohexyl methane.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Qin, Ruixuan published the artcileAlkali ions secure hydrides for catalytic hydrogenation, Application In Synthesis of 1761-71-3, the publication is Nature Catalysis (2020), 3(9), 703-709, database is CAplus.

Catalytic hydrogenation is one of the backbones of the chem. industry. Controlling the reaction behavior of the activated hydrogen species over oxide-supported metal catalysts is essential. Aside from the expected addition to substrates, the activated hydrogen species would also destroy the active structures. Here we show that, with the assistance of alkali cations, the atomically dispersed Ru(III) on Al₂O₃ exhibits enhanced performance in the hydrogenation of a broad range of substrates. The alkali cations facilitate the hydrogenation mediated by heterolytic hydrogen species, which not only restrain the hydride species from migrating to interfacial oxygen, thus suppressing the reduction and aggregation of ruthenium, but also stabilize the neg. charged transition states and intermediates through enhanced Columbic attraction. Distinctively, an inverse H/D isotope effect related to H₂ splitting as the rate-determining step over the atomically dispersed ruthenium-catalyzed hydrogenation is predicted and confirmed.

Nature Catalysis published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C13H26N2, Application In Synthesis of 1761-71-3.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Boyarskii, V. P. published the artcileSynthesis of Aromatic Carboxylic Acids by Carbonylation of Aryl Halides in the Presence of Epoxide-Modified Cobalt Carbonyls as Catalysts, Recommanded Product: 4-Cyclohexylbenzoic acid, the publication is Russian Journal of Applied Chemistry (2005), 78(11), 1844-1848, database is CAplus.

A new procedure was developed for synthesis of aromatic and heteroaromatic acids and their derivatives (esters, salts) by carbonylation of the corresponding aryl halides. The acids are selectively formed in high yield under very mild conditions. Highly active catalytic systems, base-containing alc. solutions of cobalt carbonyl modified with epoxides, were used to activate aryl halides.

Russian Journal of Applied Chemistry published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C13H16O2, Recommanded Product: 4-Cyclohexylbenzoic acid.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Liang, Yumeng published the artcileAcyl Fluorides from Carboxylic Acids, Aldehydes, or Alcohols under Oxidative Fluorination, Formula: C13H16O2, the publication is Organic Letters (2021), 23(3), 847-852, database is CAplus and MEDLINE.

A novel reagent system to obtain acyl fluorides such as benzoyl fluoride, 4-cyclohexylbenzoyl fluoride, dodecanoyl fluoride, etc. directly from three different functional group precursors: carboxylic acids such as benzoic acid, thiophene-2-carboxylic acid, dodecanoic acid, etc. aldehydes such as benzaldehyde, picolinaldehyde, cyclopropanecarboxaldehyde, etc. or alcs. such as benzyl alc., 2-bromonicotinyl alc., 4-bromobenzyl alc., etc. was described. The transformation is achieved via a combination of trichloroisocyanuric acid and cesium fluoride, which facilitates the synthesis of various acyl fluorides in high yield (up to 99%). It can be applied to the late-stage functionalization of natural products and drug mols. that contain a carboxylic acid, an aldehyde, or an alc. group.

Organic Letters published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C13H16O2, Formula: C13H16O2.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Dragovich, Peter S. published the artcileFragment-based design of 3-aminopyridine-derived amides as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT), Recommanded Product: 4-Cyclohexylbenzoic acid, the publication is Bioorganic & Medicinal Chemistry Letters (2014), 24(3), 954-962, database is CAplus and MEDLINE.

The fragment-based identification of two novel and potent biochem. inhibitors of the nicotinamide phosphoribosyltransferase (NAMPT) enzyme is described. These compounds (51 and 63) incorporate an amide moiety derived from 3-aminopyridine, and are thus structurally distinct from other known anti-NAMPT agents. Each exhibits potent inhibition of NAMPT biochem. activity (IC₅₀ = 19 and 15 nM, resp.) as well as robust antiproliferative properties in A2780 cell culture experiments (IC₅₀ = 121 and 99 nM, resp.). However, addnl. biol. studies indicate that only inhibitor 51 exerts its A2780 cell culture effects via a NAMPT-mediated mechanism. The crystal structures of both 51 and 63 in complex with NAMPT are also independently described.

Bioorganic & Medicinal Chemistry Letters published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C13H16O2, Recommanded Product: 4-Cyclohexylbenzoic acid.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Zhao, Ziyin published the artcileCytosolic protein delivery via metabolic glycoengineering and bioorthogonal click reactions, Computed Properties of 1353016-70-2, the publication is Biomaterials Science (2021), 9(13), 4639-4647, database is CAplus and MEDLINE.

Cytosolic protein delivery holds great potential for the development of protein-based biotechnologies and therapeutics. Currently, cytosolic protein delivery is mainly achieved with the assistance of various carriers. Herein, we present a universal and effective strategy for carrier-free cytosolic protein delivery via metabolic glycoengineering and bioorthogonal click reactions. Ac₄ManNAz (AAM), an azido-modified N-acetylmannosamine analog, was first employed to label tumor cell surfaces with abundant azido groups via glycometabolism. Then, proteins including RNase A, cytochrome C (Cyt C), and bovine serum albumin (BSA) were covalently modified with dibenzocyclooctyne (DBCO). Based on the highly efficient bioorthogonal click reactions between DBCO and azido, DBCO-modified proteins could be efficiently internalized by azido-labeled cancer cells. RNase A-DBCO could largely maintain its enzymic activity and, thus, led to notable anti-tumor efficacy in HeLa and B16F10 cells in vitro and in B16F10 xenograft tumors in vivo. This study therefore provides a simple and powerful approach for carrier-free protein delivery and would have broad applicability in anti-tumor protein therapy.

Biomaterials Science published new progress about 1353016-70-2. 1353016-70-2 belongs to quinuclidine, auxiliary class Other Aromatic Heterocyclic,Carboxylic acid,Amide,Inhibitor,Inhibitor, name is Dbco-acid, and the molecular formula is C6H8N2O2, Computed Properties of 1353016-70-2.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Li, Yan Mei published the artcileTailored modular assembly derived self-healing polythioureas with largely tunable properties covering plastics, elastomers and fibers, Formula: C13H26N2, the publication is Nature Communications (2022), 13(1), 2633, database is CAplus and MEDLINE.

To impart self-healing polymers largely adjustable dynamicity and mech. performance, here we develop libraries of catalyst-free reversible polythioureas directly from commodity 1,4-phenylene diisothiocyanate and amines via facile click chem. based modular assembly. By using the amine modules with various steric hindrances and flexibilities, the reversible thiourea units acquire triggering temperatures from room temperature to 120 °C. Accordingly, the derived self-healable, recyclable and controlled degradable dynamically crosslinked polythioureas can take effect within wide temperature range. Moreover, mech. properties of the materials can be tuned covering plastics, elastomers and fibers using (i) different assemble modules or (ii) solid-state stretching. Particularly, unidirectional stretching leads to the record-high tensile strength of 266 MPa, while bidirectional stretching provides the materials with biaxial strengths up to over 120 MPa. The mol. mechanism and technol. innovations discussed in this work may benefit promotion and application of self-healing polymers towards greatly diverse demands and scenarios.

Nature Communications published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C13H26N2, Formula: C13H26N2.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Xiang, Kang published the artcileTunable C-H arylation and acylation of azoles with carboxylic acids by Pd/Cu cooperative catalysis, Product Details of C13H16O2, the publication is Organic Chemistry Frontiers (2021), 8(11), 2543-2550, database is CAplus.

The direct C-H arylation and acylation of azoles with carboxylic acids were achieved through Pd/Cu cooperative catalysis. Various biaryls and biaryl ketones were selectively produced in good to high yields from the same substrates. The key factor of high chemoselectivity was the choice of a suitable phosphine ligand: biaryls were generated selectively with dppp as the ligand, while biaryl ketones were obtained with high selectivity using dpph or Ph₂PCy as the ligand.

Organic Chemistry Frontiers published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C3H6O2, Product Details of C13H16O2.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Jiang, Kunming published the artcilePalladium-Catalyzed Cross-Coupling Polymerization: A New Access to Cross-Conjugated Polymers with Modifiable Structure and Tunable Optical/Conductive Properties, Recommanded Product: 2′-(Dicyclohexylphosphino)-N2,N2,N6,N6-tetramethyl-[1,1′-biphenyl]-2,6-diamine, the publication is Macromolecules (Washington, DC, United States) (2018), 51(23), 9662-9668, database is CAplus.

While the synthesis of conjugated polymers has received significant attention, the preparation of cross-conjugated polymers, where the π-electron delocalization cannot extend along the backbone, has received much less success. We have exploited a new catalytic polymerization process and developed the Pd-catalyzed cross-coupling enabled synthesis of cross-conjugated polymers with readily accessible N-tosylhydrazones and aryl halides. A broad scope of cross-conjugated polymers with good processability and thermal stability has been prepared in high yields using dialkylbiarylphospine-Pd precatalysts. Owing to their unique vinyl structures, these polymers could be easily modified in postpolymn. fashions to impart high degrees of structural complexities. Moreover, these materials were shown to have interesting and tunable optical and conductive properties, featuring their great potentials in a variety of applications.

Macromolecules (Washington, DC, United States) published new progress about 1160556-64-8. 1160556-64-8 belongs to quinuclidine, auxiliary class Mono-phosphine Ligands, name is 2′-(Dicyclohexylphosphino)-N2,N2,N6,N6-tetramethyl-[1,1′-biphenyl]-2,6-diamine, and the molecular formula is C28H41N2P, Recommanded Product: 2′-(Dicyclohexylphosphino)-N2,N2,N6,N6-tetramethyl-[1,1′-biphenyl]-2,6-diamine.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider