Zhao, Bo-Liang et al. published their research in Asian Journal of Organic Chemistry in 2015 | CAS: 1256245-79-0

3-((3,5-Bis(trifluoromethyl)phenyl)amino)-4-(((1R)-(6-methoxyquinolin-4-yl)(5-vinylquinuclidin-2-yl)methyl)amino)cyclobut-3-ene-1,2-dione (cas: 1256245-79-0) belongs to quinuclidine derivatives. Quinuclidine derivatives are also widely utilized as homogeneous or heterogeneous catalysts in various asymmetric processes such as Morita鈥揃aylis鈥揌illman reactions, Sharpless dihydroxylation reactions, and phase-transfer catalytic reactions. The configuration at C-8 (quinuclidine attachment) and C-9 position (bearing hydroxy group) are important as they help in the orientation of hydroxy group and nitrogen atom of quinuclidine.Synthetic Route of C32H28F6N4O3

Chiral-Squaramide-Catalyzed Sulfa-Michael/Aldol Cascade Reactions for Asymmetric Synthesis of Spirothiochromanones was written by Zhao, Bo-Liang;Du, Da-Ming. And the article was included in Asian Journal of Organic Chemistry in 2015.Synthetic Route of C32H28F6N4O3 This article mentions the following:

In the presence of a quinidine-derived squaramide, arylmethyleneindanones I [R = Ph, 4-FC6H4, 2-ClC6H4, 4-ClC6H4, 4-BrC6H4, 2,4-Cl2C6H3, 2-MeC6H4, 4-MeC6H4, 2-MeOC6H4, 4-MeOC6H4, 3,4-(MeO)2C6H3, 3-O2NC6H4, 4-O2NC6H4, 1-naphthyl, 2-thienyl; R1 = H, Br, Cl; R2 = H, Me] underwent diastereoselective and enantioselective sulfa-Michael/aldol cascade reactions with 2-mercaptobenzaldehyde to yield spiroindanethiochromandiones II [R = Ph, 4-FC6H4, 2-ClC6H4, 4-ClC6H4, 4-BrC6H4, 2,4-Cl2C6H3, 2-MeC6H4, 4-MeC6H4, 2-MeOC6H4, 4-MeOC6H4, 3,4-(MeO)2C6H3, 3-O2NC6H4, 4-O2NC6H4, 1-naphthyl, 2-thienyl; R1 = H, Br, Cl; R2 = H, Me]. Under analogous conditions, dialkylidenecycloalkanones III (R3 = Ph, 4-BrC6H4, 4-MeC6H4; X = CH2, O; Y = bond, CH2) underwent diastereoselective and enantioselective sulfa-Michael/aldol cascade reactions to yield spirothiochromanones IV (R3 = Ph, 4-BrC6H4, 4-MeC6H4; X = CH2, O; Y = bond, CH2). This organocatalytic cascade reaction provides easy access to highly functionalized spirothiochromanones with three contiguous stereocenters, including one quaternary center, in excellent yields up to 99% with excellent diastereoselectivity up to >99:1. In the experiment, the researchers used many compounds, for example, 3-((3,5-Bis(trifluoromethyl)phenyl)amino)-4-(((1R)-(6-methoxyquinolin-4-yl)(5-vinylquinuclidin-2-yl)methyl)amino)cyclobut-3-ene-1,2-dione (cas: 1256245-79-0Synthetic Route of C32H28F6N4O3).

3-((3,5-Bis(trifluoromethyl)phenyl)amino)-4-(((1R)-(6-methoxyquinolin-4-yl)(5-vinylquinuclidin-2-yl)methyl)amino)cyclobut-3-ene-1,2-dione (cas: 1256245-79-0) belongs to quinuclidine derivatives. Quinuclidine derivatives are also widely utilized as homogeneous or heterogeneous catalysts in various asymmetric processes such as Morita鈥揃aylis鈥揌illman reactions, Sharpless dihydroxylation reactions, and phase-transfer catalytic reactions. The configuration at C-8 (quinuclidine attachment) and C-9 position (bearing hydroxy group) are important as they help in the orientation of hydroxy group and nitrogen atom of quinuclidine.Synthetic Route of C32H28F6N4O3

Referemce:
Quinuclidine – Wikipedia,
Quinuclidine | C7H13N | ChemSpider