Efficient unified synthesis of diverse bridged polycyclic scaffolds using a complexity-generating ‘stitching’ annulation approach was written by Rice, Scott;Cox, Daniel J.;Marsden, Stephen P.;Nelson, Adam. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2021.Computed Properties of C7H16Cl2N2 This article mentions the following:
Regioselective and stereospecific directed C-H arylation of simple amine substrates e.g., exo-2-aminonorbornane, and cyclisation, delivered three-dimensional scaffolds e.g., (1R,3aR,4R,10bS)-2,3,3a,4,5,10b-hexahydro-1,4-methanobenzo[c]cyclopenta[e]azepin-6(1H)-one. The unified approach significantly expanded the range of bridged ring systems that contain both a nitrogen atom and an aromatic ring. In the experiment, the researchers used many compounds, for example, 3-Aminoquinuclidine dihydrochloride (cas: 6530-09-2Computed Properties of C7H16Cl2N2).
3-Aminoquinuclidine dihydrochloride (cas: 6530-09-2) belongs to quinuclidine derivatives. Quinuclidine acts as a catalyst, a chemical building block and is used in organic synthesis. Asymmetric construction of quinuclidine derivatives has been realized by an iridium-catalyzed allylic dearomatization reaction. The catalytic system, derived from [Ir(cod)Cl]2 and the Feringa ligand, tolerates a broad range of substrates. A large array of quinuclidine derivatives can be obtained under mild conditions in good to excellent yields (68%–96%), diastereoselectivity (up to >20/1 dr), and enantioselectivity (up to >99% ee).Computed Properties of C7H16Cl2N2
Referemce:
Quinuclidine – Wikipedia,
Quinuclidine | C7H13N | ChemSpider