Enantioselective [3+2] annulation of 4-isothiocyanato pyrazolones and alkynyl ketones under organocatalysis was written by Wang, Wenyao;Wei, Shiqiang;Bao, Xiaoze;Nawaz, Shah;Qu, Jingping;Wang, Baomin. And the article was included in Organic & Biomolecular Chemistry in 2021.SDS of cas: 1256245-79-0 This article mentions the following:
An asym. [3+2] annulation reaction of 4-isothiocyanato pyrazolones with alkynyl ketones in the presence of an organic catalyst derived from a cinchona alkaloid under mild conditions was realized. This protocol provided unprecedented expeditious accessed to a wide range of optically active spiro[pyrroline-pyrazolones] with various electronic properties in high yields with good to excellent enantioselectivities. In the experiment, the researchers used many compounds, for example, 3-((3,5-Bis(trifluoromethyl)phenyl)amino)-4-(((1R)-(6-methoxyquinolin-4-yl)(5-vinylquinuclidin-2-yl)methyl)amino)cyclobut-3-ene-1,2-dione (cas: 1256245-79-0SDS of cas: 1256245-79-0).
3-((3,5-Bis(trifluoromethyl)phenyl)amino)-4-(((1R)-(6-methoxyquinolin-4-yl)(5-vinylquinuclidin-2-yl)methyl)amino)cyclobut-3-ene-1,2-dione (cas: 1256245-79-0) belongs to quinuclidine derivatives. Quinuclidine is found as a structural component of some biomolecules including quinine. Asymmetric construction of quinuclidine derivatives has been realized by an iridium-catalyzed allylic dearomatization reaction. The catalytic system, derived from [Ir(cod)Cl]2 and the Feringa ligand, tolerates a broad range of substrates. A large array of quinuclidine derivatives can be obtained under mild conditions in good to excellent yields (68%–96%), diastereoselectivity (up to >20/1 dr), and enantioselectivity (up to >99% ee).SDS of cas: 1256245-79-0
Referemce:
Quinuclidine – Wikipedia,
Quinuclidine | C7H13N | ChemSpider