Month: June 2024

Asymmetric induction in the synthesis of α-amino acid under phase transfer catalysis conditions was written by Jin, Chunxue;Xiong, Lizeng;Chen, Zikang;Yu, Lingchong. And the article was included in Beijing Shifan Daxue Xuebao, Ziran Kexueban in 1993.Computed Properties of C26H29ClN2O This article mentions the following:

Gabriel reaction of potassium phthalimide and (-)-menthyl α-bromocarboxylates are studied under solid-liquid chiral and nonchiral phase transfer catalysis conditions. Four optically active 2-phthalimido esters are synthesized under varied phase transfer catalysis conditions. Four L-predominant α-amino acids with optical yields 3% ∼ 13.5% are obtained by hydrazinolysis and hydrolysis of these N-substituted phthalimides. In the experiment, the researchers used many compounds, for example, (1S,2R,4S,5R)-1-Benzyl-2-(hydroxy(quinolin-4-yl)methyl)-5-vinylquinuclidin-1-ium chloride (cas: 69221-14-3Computed Properties of C26H29ClN2O).

(1S,2R,4S,5R)-1-Benzyl-2-(hydroxy(quinolin-4-yl)methyl)-5-vinylquinuclidin-1-ium chloride (cas: 69221-14-3) belongs to quinuclidine derivatives. Quinuclidine acts as a catalyst, a chemical building block and is used in organic synthesis. It is employed to prepare quinine and alkaloids. Carbamoyl boranes are generally prepared as adducts with tertiary amines, such as trialkyl amines, pyridine, or quinuclidine, via two synthetic approaches based either on amidation of amine-carboxyborane adducts or on hydrolysis of amine-cyanoboranes.Computed Properties of C26H29ClN2O

Referemce:
Quinuclidine – Wikipedia,
Quinuclidine | C7H13N | ChemSpider

Catalytic Atropenantioselective Heteroannulation between Isocyanoacetates and Alkynyl Ketones: Synthesis of Enantioenriched Axially Chiral 3-Arylpyrroles was written by Zheng, Sheng-Cai;Wang, Qian;Zhu, Jieping. And the article was included in Angewandte Chemie, International Edition in 2019.Application In Synthesis of 2-(Diphenylphosphino)-N-((S)-(6-methoxyquinolin-4-yl)((1S,2S,4S,5R)-5-vinylquinuclidin-2-yl)methyl)benzamide This article mentions the following:

In the presence of Ag₂O and a quinine- or quinidine-derived phosphine, arylethynyl aryl ketones such as I (R = Ph, 4-BrC₆H₄, 4-ClC₆H₄, 4-MeOC₆H₄, 4-MeC₆H₄, 4-t-BuC₆H₄, 3-MeOC₆H₄; R¹ = Me, Et, i-Pr, Ac) underwent enantioselective cycloaddition reactions with isocyanoacetates such as Et isocyanoacetate to yield (aryl)aroylpyrrolecarboxylates such as II (R = Ph, 4-BrC₆H₄, 4-ClC₆H₄, 4-MeOC₆H₄, 4-MeC₆H₄, 4-t-BuC₆H₄, 3-MeOC₆H₄; R¹ = Me, Et, i-Pr, Ac) in 46-98% yields and in 82-96% ee. In the experiment, the researchers used many compounds, for example, 2-(Diphenylphosphino)-N-((S)-(6-methoxyquinolin-4-yl)((1S,2S,4S,5R)-5-vinylquinuclidin-2-yl)methyl)benzamide (cas: 1630973-03-3Application In Synthesis of 2-(Diphenylphosphino)-N-((S)-(6-methoxyquinolin-4-yl)((1S,2S,4S,5R)-5-vinylquinuclidin-2-yl)methyl)benzamide).

2-(Diphenylphosphino)-N-((S)-(6-methoxyquinolin-4-yl)((1S,2S,4S,5R)-5-vinylquinuclidin-2-yl)methyl)benzamide (cas: 1630973-03-3) belongs to quinuclidine derivatives. Quinuclidine is found as a structural component of some biomolecules including quinine. Traditionally, quinuclidine scaffolds can be constructed by second-order nucleophilic substitution (SN2) reaction or condensation reaction of piperidine derivatives. However, most of these reactions are racemic or chiral auxiliary-assisted processes.Application In Synthesis of 2-(Diphenylphosphino)-N-((S)-(6-methoxyquinolin-4-yl)((1S,2S,4S,5R)-5-vinylquinuclidin-2-yl)methyl)benzamide

Referemce:
Quinuclidine – Wikipedia,
Quinuclidine | C7H13N | ChemSpider