The important role of 40117-63-3

With the complex challenges of chemical substances, we look forward to future research findings about Quinuclidine-4-carboxylic acid hydrochloride

Name is Quinuclidine-4-carboxylic acid hydrochloride, as a common heterocyclic compound, it belongs to quinuclidine compound, and cas is 40117-63-3, its synthesis route is as follows.

To a stirred suspension of quinuclidine-4-carboxylic acid hydrochloride (5.5 g) in 30 mL of dry THF at 0 C. was added borane dimethyl sulfide complex (6.7 g, 3 eq.). The reaction mixture was stirred at room temperature for 1 hr and heated to reflux for 16 hr. It was then quenched with drop-wise addition of methanol (7 mL) at 0 C. The solvent was then removed under reduced pressure, and the crude product obtained was purified by column chromatography (Silica gel, 20% EA:Hexane) to afford the product quinuclidin-4-ylmethanol N-borane complex as a white solid (1.35 g, 30%).

With the complex challenges of chemical substances, we look forward to future research findings about Quinuclidine-4-carboxylic acid hydrochloride

Reference£º
Patent; CoMentis, Inc.; BILCER, Geoffrey M.; NG, Raymond; (104 pag.)US2016/9706; (2016); A1;,
Quinuclidine – Wikipedia
Quinuclidine | C7H13N | ChemSpider