Electric Literature of 112-44-7, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 112-44-7, Name is Undecanal, SMILES is CCCCCCCCCCC=O, belongs to quinuclidines compound. In a article, author is McDonald, Ivar M., introduce new discover of the category.
Discovery of a novel series of quinolone alpha 7 nicotinic acetylcholine receptor agonists
High throughput screening led to the identification of a novel series of quinolone alpha 7 nicotinic acetylcholine receptor (nAChR) agonists. Optimization of an HTS hit (1) led to 4-phenyl-1-(quinuclidin-3-ylmethyl)quinolin-2(1H)-one, which was found to be potent and selective. Poor brain penetrance in this series was attributed to transporter-mediated efflux, which was in turn due to high pK(a). A novel 4-fluoroquinuclidine significantly lowered the pK(a) of the quinuclidine moiety, reducing efflux as measured by a Caco-2 assay. (C) 2013 Elsevier Ltd. All rights reserved.
Electric Literature of 112-44-7, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 112-44-7.
Reference:
Quinuclidine – Wikipedia,
,Quinuclidine | C7H13N | ChemSpider