Category: quinuclidine. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: Bis(norbornadiene)rhodium (I) tetrafluoroborate, is researched, Molecular C14H8BF4Rh, CAS is 36620-11-8, about Scalable Asymmetric Synthesis of MK-8998, a T-type Calcium Channel Antagonist. Author is Zhong, Yong-Li; Moore, Jeffrey C.; Shevlin, Michael; Shultz, C. Scott; Kosjek, Birgit; Chen, Yonggang; Janey, Jacob M.; Tan, Lushi.
Two scalable and efficient synthetic routes for the synthesis of a T-type calcium channel antagonist MK-8998 were developed from a simple pyridine building block. The key step to set the stereochem. relied on either chiral rhodium catalyst-mediated asym. hydrogenation of an enamide or transamination of an arylketone that provided the corresponding product in high enantioselectivity and high yield.
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Quinuclidine – Wikipedia,
Quinuclidine | C7H13N | ChemSpider