Zhong, Yong-Li; Moore, Jeffrey C.; Shevlin, Michael; Shultz, C. Scott; Kosjek, Birgit; Chen, Yonggang; Janey, Jacob M.; Tan, Lushi published the article 《Scalable Asymmetric Synthesis of MK-8998, a T-type Calcium Channel Antagonist》. Keywords: scalable MK 8998 preparation enantioselective calcium channel antagonist.They researched the compound: Bis(norbornadiene)rhodium (I) tetrafluoroborate( cas:36620-11-8 ).Related Products of 36620-11-8. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:36620-11-8) here.
Two scalable and efficient synthetic routes for the synthesis of a T-type calcium channel antagonist MK-8998 were developed from a simple pyridine building block. The key step to set the stereochem. relied on either chiral rhodium catalyst-mediated asym. hydrogenation of an enamide or transamination of an arylketone that provided the corresponding product in high enantioselectivity and high yield.
In some applications, this compound(36620-11-8)Related Products of 36620-11-8 is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.
Reference:
Quinuclidine – Wikipedia,
Quinuclidine | C7H13N | ChemSpider