So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Lv, Jie; Xu, Jun; Pan, Xuling; Jin, Zhichao; Chi, Yonggui Robin researched the compound: (5aS,10bR)-2-(2,4,6-Trichlorophenyl)-4,5a,6,10b-tetrahydro-2H-indeno[2,1-b][1,2,4]triazolo[4,3-d][1,4]oxazin-11-ium tetrafluoroborate( cas:1214711-48-4 ).Category: quinuclidine.They published the article 《Carbene-catalyzed activation of cyclopropylcarbaldehydes for Mannich reaction and δ-lactam formation: remote enantioselectivity control and dynamic kinetic asymmetric transformation》 about this compound( cas:1214711-48-4 ) in Science China: Chemistry. Keywords: multicyclic lactam stereospecific asym diastereoselective preparation dynamic kinetic transformation; cyclopropylcarbaldehyde asym Mannich NHC catalyzed. We’ll tell you more about this compound (cas:1214711-48-4).
An N-heterocyclic carbene (NHC)-catalyzed enantioselective Mannich reaction of the remote γ-carbon of cyclopropylcarbaldehydes was disclosed for the first time to yield δ-lactam compounds such as I [R = C6H5, 2-FC6H4, 2-thienyl, etc.; R1 = Me, Et, 4-O2NBn, R2 = H, Cl, Me, etc.]. Diastereo- and enantiomerically enriched multicyclic δ-lactam compound was afforded as the main product from 8 possible stereo-specific isomers through dynamic kinetic asym. transformation (DYKAT) processes. Multiple chiral functional mols. could be afforded from the lactam products through simple protocols with retentions of the optical purities.
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Reference:
Quinuclidine – Wikipedia,
Quinuclidine | C7H13N | ChemSpider