Kumar, I. V. Sunil published the artcileIdentification, synthesis and characterization of impurities of Montelukast sodium, Related Products of quinuclidine, the publication is Asian Journal of Chemistry (2011), 23(10), 4536-4546, database is CAplus.
Montelukast sodium is a selective leukotriene receptor antagonist [i.e., 1-[[[(1R)-1-[3-[(1E)-2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic acid sodium salt] which inhibits cysteinyl leukotriene CysLT1 receptor. Various synthesis methods of Montelukast have been published. During laboratory optimization and later in-bulk synthesis, the formation of various impurities was detected. Besides, a Pharma Europa draft mentions nine process-related impurities. However, the method of preparation of most of these impurities is not available in the literature. Also, different route of synthesis will have different impurity profile and those process related impurities are not covered in pharmacopeia issues. In this study the authors report the synthesis of possible process impurities and the target compounds thus formed include several impurities previously mentioned in Pharma Europa.
Asian Journal of Chemistry published new progress about 162515-68-6. 162515-68-6 belongs to quinuclidine, auxiliary class Thiol,Carboxylic acid,Aliphatic cyclic hydrocarbon, name is 2-(1-(Mercaptomethyl)cyclopropyl)acetic acid, and the molecular formula is C6H10O2S, Related Products of quinuclidine.
Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider