Yan, Lin published the artcile2-Aryl(pyrrolidin-4-yl)acetic acids are potent agonists of sphingosine-1-phosphate (S1P) receptors, Application In Synthesis of 20029-52-1, the publication is Bioorganic & Medicinal Chemistry Letters (2006), 16(13), 3564-3568, database is CAplus and MEDLINE.
2-Aryl(pyrrolidin-4-yl)acetic acids I [R = i-Bu, cyclopentyl, cyclohexyl, F3C(CH2)2, 3,3-difluoro-1-cyclopentyl, 4,4-difluoro-1-cyclohexyl] and II were synthesized and their biol. activities as agonists of S1P receptors were evaluated. These analogs were able to induce lowering of lymphocyte counts in the peripheral blood of mice and were found to have good overall pharmacokinetic properties in rats.
Bioorganic & Medicinal Chemistry Letters published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C8H6ClNO, Application In Synthesis of 20029-52-1.
Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider