Wang, Wentao published the artcileMultifunctional and High Affinity Polymer Ligand that Provides Bio-Orthogonal Coating of Quantum Dots, Synthetic Route of 1353016-70-2, the publication is Bioconjugate Chemistry (2016), 27(9), 2024-2036, database is CAplus and MEDLINE.
The authors detail the design of hydrophilic metal-coordinating ligands and their use for the effective coating of luminescent quantum dots. The ligand design exploits the specific, reagent-free nucleophilic addition reaction of amine-modified mols. toward maleic anhydride to introduce several lipoic acid metal-anchors, hydrophilic zwitterion moieties and specific reactive groups along a poly(isobutylene-alt-maleic anhydride) (PIMA) chain. Tunable reactive groups tested in this study include azide, biotin, carboxyl, and amine. Cap exchange with these multi-lipoic acid ligands via a photochem. ligation strategy yields homogeneous QD dispersions that are colloidally stable over several biol.-relevant conditions and for extended periods of time. The zwitterionic coating yields compact nanoparticle size and imparts non-sticky surface properties onto the QDs, preventing protein absorption. The introduction of a controllable number of reactive groups allows conjugation of the QDs to biomols. via bio-orthogonal coupling chemistries including: (1) attachment of the neurotransmitter dopamine to QDs via amine-isothiocyanate reaction to produce a platform capable of probing interactions with cysteine in proteins, based on charge transfer interactions; (2) self-assembly of biotinylated QDs with streptavidin-dye; (3) ligation of azide-functionalized QDs to cyclooctyne-modified transferrin via copper-free click chem. for intracellular delivery. This ligand design strategy can be used to prepare an array of metal-coordinating ligands adapted for coating other inorganic nanoparticles, including magnetic and plasmonic nanomaterials.
Bioconjugate Chemistry published new progress about 1353016-70-2. 1353016-70-2 belongs to quinuclidine, auxiliary class Other Aromatic Heterocyclic,Carboxylic acid,Amide,Inhibitor,Inhibitor, name is Dbco-acid, and the molecular formula is C8H11BO2, Synthetic Route of 1353016-70-2.
Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider