Wang, Haibo published the artcilePincer thioamide and pincer thioimide palladium complexes catalyze highly efficient Negishi coupling of primary and secondary alkyl zinc reagents at room temperature, Quality Control of 20029-52-1, the publication is Chemistry – A European Journal (2009), 15(6), 1499-1507, database is CAplus and MEDLINE.
Two pincer thioamide and thioimide PdII complexes were synthesized from 2,6-bis(butylaminothiocarbonyl)pyridine and their structures were confirmed by X-ray anal. Both complexes were found to be efficient catalysts for Negishi couplings involving primary and secondary alkylzinc reagents bearing β-hydrogen atoms. At a concentration of 0.1- 0.5 mol% both catalysts readily promoted reactions at room temperature or even at 0 °C. The operational simplicity of these processes, in conjunction with the easy accessibility of both catalysts and substrates, promises synthetic utility of this new methodol. An experiment on a scale of 19.35 g carried out at very low catalyst loading (turnover number: 6100 000) highlighted the potential application of the catalytic system. Monoalkyl and dialkylzinc reagents displayed different reactivities and selectivities in reactions with aryl iodides, and isomerization in reactions involving acyclic secondary alkyl zinc derivatives was suppressed by using appropriate amounts of dialkylzinc reagents. Based on preliminary kinetic profiles and reaction evidence, three possible pathways are proposed for the reactions involving acyclic secondary alkyl zinc reagents to rationalize the difference between monoalkyl and dialkyl zinc derivatives
Chemistry – A European Journal published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C20H17FO4S, Quality Control of 20029-52-1.
Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider