Ke, Li-na’s team published research in Xiamen Daxue Xuebao, Ziran Kexueban in 43 | CAS: 20029-52-1

Xiamen Daxue Xuebao, Ziran Kexueban published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C13H16O2, Recommanded Product: 4-Cyclohexylbenzoic acid.

Ke, Li-na published the artcileInhibitory effects of benzoic acid and its derivatives on the polyphenoloxidase from the 5th instar of Pieris rapae L., Recommanded Product: 4-Cyclohexylbenzoic acid, the publication is Xiamen Daxue Xuebao, Ziran Kexueban (2004), 43(6), 856-860, database is CAplus.

The polyphenoloxidase (PPO) is more responsible for enzymic browning during the growth of the insects. It also is involved in the defense reaction and has some certain relation with the immune condition of the insects. The polyphenoloxidase is a metalloenzyme oxidase which catalyzes two distinct reactions of melanin synthesis the hydroxylation of a monophenol and the oxidation of ωmi-diphenol to the corresponding ωmi-quinone. A great number of benzoic acid family compounds can inhibit the enzyme activity for the oxidation of L-DOPA. In the present paper, partial characteristics and inhibitory kinetics of polyphenoloxidase (PPO) from the 5th instar of Pieris rapae L. were studied. The results show that benzoic acid, p-cyanobenzoic acid, p-hydroxybenzoic acid and p-cyclohexylbenzoic acid were chosen as inhibitors of PPO for the oxidation of L-DOPA. The reactions of these inhibitors with the PPO are reversible with remaining enzyme activity. The IC50 (the inhibitor concentrations leading to 50% activity lost) were estimated to be 14.2, 16.1, 11.3 and 2.1 mmol/L, resp. The inhibitory mechanisms of p-hydroxybenzoic acid is competitive, p-cyanobenzoic acid belongs to be a mixed typed inhibitor while the others are noncompetitive inhibitors. Obviously, p-cyanobenzoic acid is the best inhibitor among the four compounds, so it may have the bright prospect in the future as the biocide.

Xiamen Daxue Xuebao, Ziran Kexueban published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C13H16O2, Recommanded Product: 4-Cyclohexylbenzoic acid.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider