Feng, Xiang-Jun published the artcileSynthesis and Immunomodulating Activity of New Analogues of Fingolimod, Name: 4-Cyclohexylbenzoic acid, the publication is Archiv der Pharmazie (Weinheim, Germany) (2012), 345(2), 93-100, database is CAplus and MEDLINE.
Five new immunomodulators I.HCl (R = H, Et, n-Pr, n-Bu, n-Pen) in which a trans-4-alkyl-substituted cyclohexane replaces the flexible C8 alkyl chain of Fingolimod were synthesized. For in-vitro test, the compounds were dissolved in DMSO as a stock solution and diluted to a desired concentration with RPMI 1640 nutrient solution For in-vivo test, the compounds were prepared in pathogen-free saline containing 0.5% DMSO. These new immunomodulators displayed more potent immunoinhibitory activities in vitro and moderate immunomodulating activities in vivo. They show therapeutic effects on DNFB-induced DTH reaction and inhibitory effects on the antigen-specific T-cell proliferation.
Archiv der Pharmazie (Weinheim, Germany) published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C13H16O2, Name: 4-Cyclohexylbenzoic acid.
Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider