Modular and Tunable Chemosensor Scaffold for Divalent Zinc was written by Shults, Melissa D.;Pearce, Dierdre A.;Imperiali, Barbara. And the article was included in Journal of the American Chemical Society in 2003.Application of 200132-54-3 This article mentions the following:
A modular peptide scaffold was developed for fluorescent sensing of divalent zinc. The signaling component of the chemosensor is the chelation-sensitive fluorophore 8-hydroxy-5-(N,N-dimethylsulfonamido)-2-methylquinoline, which is prepared as the protected amino acid derivative Fmoc-Sox-OH and integrated into peptide sequences. Nineteen synthetic peptides incorporating the signaling element exhibit a range of affinities for Zn2+ through variation and number of Zn2+ ligands, ligand arrangement and the 尾-turn sequence that acts as a preorganization element between the ligands. The stoichiometry of the peptide-Zn2+ complexes is evaluated by several criteria. The fluorescence response of these peptides to pH and various important metal ions is reported. Eleven of these sequences form only 1:1 complexes with Zn2+ and their affinities range from 10 nM to nearly 1 渭M. When used in concert, these sensors can provide Zn2+ concentration information in a valuable range. In the experiment, the researchers used many compounds, for example, (1S,2S,4S,5R)-2-((R)-(Allyloxy)(quinolin-4-yl)methyl)-1-(anthracen-9-ylmethyl)-5-vinylquinuclidin-1-ium bromide (cas: 200132-54-3Application of 200132-54-3).
(1S,2S,4S,5R)-2-((R)-(Allyloxy)(quinolin-4-yl)methyl)-1-(anthracen-9-ylmethyl)-5-vinylquinuclidin-1-ium bromide (cas: 200132-54-3) belongs to quinuclidine derivatives. Quinuclidine is found as a structural component of some biomolecules including quinine. The configuration at C-8 (quinuclidine attachment) and C-9 position (bearing hydroxy group) are important as they help in the orientation of hydroxy group and nitrogen atom of quinuclidine.Application of 200132-54-3
Referemce:
Quinuclidine – Wikipedia,
Quinuclidine | C7H13N | ChemSpider