The cinchona alkaloid squaramide catalyzed asymmetric Pictet-Spengler reaction and related theoretical studies was written by Qi, Liang;Hou, Huacui;Ling, Fei;Zhong, Weihui. And the article was included in Organic & Biomolecular Chemistry in 2018.HPLC of Formula: 1256245-79-0 This article mentions the following:
The asym. Pictet-Spengler reaction between tryptamine derivatives and aldehydes has been developed with a cinchona alkaloid squaramide as the catalyst, affording the corresponding tetrahedron-β-carbolines in good to excellent yields and ee values. A rational mechanistic pathway has also been proposed based on DFT calculations In the experiment, the researchers used many compounds, for example, 3-((3,5-Bis(trifluoromethyl)phenyl)amino)-4-(((1R)-(6-methoxyquinolin-4-yl)(5-vinylquinuclidin-2-yl)methyl)amino)cyclobut-3-ene-1,2-dione (cas: 1256245-79-0HPLC of Formula: 1256245-79-0).
3-((3,5-Bis(trifluoromethyl)phenyl)amino)-4-(((1R)-(6-methoxyquinolin-4-yl)(5-vinylquinuclidin-2-yl)methyl)amino)cyclobut-3-ene-1,2-dione (cas: 1256245-79-0) belongs to quinuclidine derivatives. Quinuclidine acts as a catalyst, a chemical building block and is used in organic synthesis. It is employed to prepare quinine and alkaloids. Traditionally, quinuclidine scaffolds can be constructed by second-order nucleophilic substitution (SN2) reaction or condensation reaction of piperidine derivatives. However, most of these reactions are racemic or chiral auxiliary-assisted processes.HPLC of Formula: 1256245-79-0
Referemce:
Quinuclidine – Wikipedia,
Quinuclidine | C7H13N | ChemSpider