Category: 1160556-64-8

Zhang, He published the artcileA new protocol for synthesizing diarylmethanes using a benzyltitanium reagent as a nucleophile, Synthetic Route of 1160556-64-8, the publication is Journal of Chemical Research (2022), 46(2), 17475198221091941, database is CAplus.

The first palladium-catalyzed cross-coupling of various substituted benzyltitaniums with aryl triflates is presented for the synthesis of diarylmethanes in yields of up to 94% through highly selective C-O bond functionalization. The benzyltitaniums act as nucleophiles to realize the C(sp²)-C(sp³) cross-coupling with high efficiency within short reaction times. The reactions proceed at 60°C and show excellent functional group tolerance.

Journal of Chemical Research published new progress about 1160556-64-8. 1160556-64-8 belongs to quinuclidine, auxiliary class Mono-phosphine Ligands, name is 2′-(Dicyclohexylphosphino)-N2,N2,N6,N6-tetramethyl-[1,1′-biphenyl]-2,6-diamine, and the molecular formula is C19H22BNO5, Synthetic Route of 1160556-64-8.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Huang, Yao published the artcileHighly regioselective and diastereodivergent aminomethylative annulation of dienyl alcohols enabled by a hydrogen-bonding assisting effect, Category: quinuclidine, the publication is Chemical Science (2022), 13(8), 2317-2323, database is CAplus and MEDLINE.

A ligand-controlled palladium-catalyzed highly regioselective and diastereodivergent aminomethylative annulation of dienyl alcs. with aminals were established, which allowed for producing either cis- or trans-disubstituted isochromans in good yields with complete regioselectivity and good to excellent diastereoselectivity. Moreover, the chiral cis-products were also obtained in good yields with up to 94% ee by using a chiral phosphinamide as the ligand. Mechanistic studies revealed that the hydroxyl group played a key role in facilitating the Pd-catalyzed Heck insertion regioselectively taking place across the internal C=C bond of conjugated dienes.

Chemical Science published new progress about 1160556-64-8. 1160556-64-8 belongs to quinuclidine, auxiliary class Mono-phosphine Ligands, name is 2′-(Dicyclohexylphosphino)-N2,N2,N6,N6-tetramethyl-[1,1′-biphenyl]-2,6-diamine, and the molecular formula is C28H41N2P, Category: quinuclidine.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Jiang, Kunming published the artcilePalladium-Catalyzed Cross-Coupling Polymerization: A New Access to Cross-Conjugated Polymers with Modifiable Structure and Tunable Optical/Conductive Properties, Recommanded Product: 2′-(Dicyclohexylphosphino)-N2,N2,N6,N6-tetramethyl-[1,1′-biphenyl]-2,6-diamine, the publication is Macromolecules (Washington, DC, United States) (2018), 51(23), 9662-9668, database is CAplus.

While the synthesis of conjugated polymers has received significant attention, the preparation of cross-conjugated polymers, where the π-electron delocalization cannot extend along the backbone, has received much less success. We have exploited a new catalytic polymerization process and developed the Pd-catalyzed cross-coupling enabled synthesis of cross-conjugated polymers with readily accessible N-tosylhydrazones and aryl halides. A broad scope of cross-conjugated polymers with good processability and thermal stability has been prepared in high yields using dialkylbiarylphospine-Pd precatalysts. Owing to their unique vinyl structures, these polymers could be easily modified in postpolymn. fashions to impart high degrees of structural complexities. Moreover, these materials were shown to have interesting and tunable optical and conductive properties, featuring their great potentials in a variety of applications.

Macromolecules (Washington, DC, United States) published new progress about 1160556-64-8. 1160556-64-8 belongs to quinuclidine, auxiliary class Mono-phosphine Ligands, name is 2′-(Dicyclohexylphosphino)-N2,N2,N6,N6-tetramethyl-[1,1′-biphenyl]-2,6-diamine, and the molecular formula is C28H41N2P, Recommanded Product: 2′-(Dicyclohexylphosphino)-N2,N2,N6,N6-tetramethyl-[1,1′-biphenyl]-2,6-diamine.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Dupuy, Stephanie published the artcileTerminal-Selective Functionalization of Alkyl Chains by Regioconvergent Cross-Coupling, Product Details of C28H41N2P, the publication is Angewandte Chemie, International Edition (2016), 55(47), 14793-14797, database is CAplus and MEDLINE.

Hydrocarbons are still the most important precursors of functionalized organic mols., which has stirred interest in the discovery of new C-H bond functionalization methods. We describe herein a new step-economical approach that enables C-C bonds to be constructed at the terminal position of linear alkanes. First, we show that secondary alkyl bromides can undergo in situ conversion into alkyl zinc bromides and regioconvergent Negishi coupling with aryl or alkenyl triflates. The use of a suitable phosphine ligand favoring Pd migration enabled the selective formation of the linear cross-coupling product. Subsequently, mixtures of secondary alkyl bromides were prepared from linear alkanes by standard bromination, and regioconvergent cross-coupling then provided access to the corresponding linear arylation product in only two steps.

Angewandte Chemie, International Edition published new progress about 1160556-64-8. 1160556-64-8 belongs to quinuclidine, auxiliary class Mono-phosphine Ligands, name is 2′-(Dicyclohexylphosphino)-N2,N2,N6,N6-tetramethyl-[1,1′-biphenyl]-2,6-diamine, and the molecular formula is C28H41N2P, Product Details of C28H41N2P.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

White, Derick R. published the artcileSynthesis of Polycyclic Nitrogen Heterocycles via Cascade Pd-Catalyzed Alkene Carboamination/Diels-Alder Reactions, Safety of 2′-(Dicyclohexylphosphino)-N2,N2,N6,N6-tetramethyl-[1,1′-biphenyl]-2,6-diamine, the publication is Organic Letters (2015), 17(10), 2378-2381, database is CAplus and MEDLINE.

Cascade Pd-catalyzed alkene carboamination/Diels-Alder reactions between bromodienes and amines bearing two pendant alkenes are described [e.g., amine I + 9-bromoanthracene → II (57%)]. These transformations generate 4 bonds, 3 rings, and 3-5 stereocenters to afford polycyclic nitrogen heterocycles with high diastereoselectivity.

Organic Letters published new progress about 1160556-64-8. 1160556-64-8 belongs to quinuclidine, auxiliary class Mono-phosphine Ligands, name is 2′-(Dicyclohexylphosphino)-N2,N2,N6,N6-tetramethyl-[1,1′-biphenyl]-2,6-diamine, and the molecular formula is C12H20O6, Safety of 2′-(Dicyclohexylphosphino)-N2,N2,N6,N6-tetramethyl-[1,1′-biphenyl]-2,6-diamine.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

White, Derick R. published the artcileStereocontrolled Synthesis of Amino-Substituted Carbocycles by Pd-Catalyzed Alkene Carboamination Reactions, Synthetic Route of 1160556-64-8, the publication is Chemistry – A European Journal (2017), 23(23), 5419-5423, database is CAplus and MEDLINE.

Amino-substituted alkylidenecyclopentanes, e.g., I were synthesized through a stereoselective intermol. Pd-catalyzed alkene carboamination reaction between alkenyl triflates bearing a pendant alkene and exogenous amine nucleophiles. The reactions are effective with a range of different substrate combinations, and proceed with generally high diastereoselectivity. Use of (S)-tBuPhox as the ligand in reactions of achiral substrates provides enantioenriched products with up to 98.5:1.5 e.r.

Chemistry – A European Journal published new progress about 1160556-64-8. 1160556-64-8 belongs to quinuclidine, auxiliary class Mono-phosphine Ligands, name is 2′-(Dicyclohexylphosphino)-N2,N2,N6,N6-tetramethyl-[1,1′-biphenyl]-2,6-diamine, and the molecular formula is C9H11BO3, Synthetic Route of 1160556-64-8.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Peterson, Luke J. published the artcilePalladium-Catalyzed Alkene Carboamination Reactions of Electron-Poor Nitrogen Nucleophiles, Recommanded Product: 2′-(Dicyclohexylphosphino)-N2,N2,N6,N6-tetramethyl-[1,1′-biphenyl]-2,6-diamine, the publication is Advanced Synthesis & Catalysis (2015), 357(10), 2339-2344, database is CAplus and MEDLINE.

Modified reaction conditions that facilitate Pd-catalyzed alkene carboamination reactions of electron-deficient nitrogen nucleophiles are reported. Pent-4-enylamine derivatives bearing N-tosyl or N-trifluoroacetyl groups are coupled with aryl triflates to afford substituted pyrrolidines in good yield. These reactions proceed via a mechanism involving anti-aminopalladation of the alkene, which differs from previously reported analogous reactions of N-aryl- and N-Boc-pentenylamines. The application of these conditions to a formal synthesis of (+/-)-aphanorphine is also described.

Advanced Synthesis & Catalysis published new progress about 1160556-64-8. 1160556-64-8 belongs to quinuclidine, auxiliary class Mono-phosphine Ligands, name is 2′-(Dicyclohexylphosphino)-N2,N2,N6,N6-tetramethyl-[1,1′-biphenyl]-2,6-diamine, and the molecular formula is C28H41N2P, Recommanded Product: 2′-(Dicyclohexylphosphino)-N2,N2,N6,N6-tetramethyl-[1,1′-biphenyl]-2,6-diamine.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Hutt, Johnathon T. published the artcileSynthesis of 2,3-dihydrobenzofurans via the palladium catalyzed carboalkoxylation of 2-allylphenols, Computed Properties of 1160556-64-8, the publication is Organic Chemistry Frontiers (2016), 3(10), 1314-1318, database is CAplus and MEDLINE.

A new Pd-catalyzed alkene carboalkoxylation strategy for the preparation of 2,3-dihydrobenzofurans, e.g., I was described. This method effects the coupling of readily available 2-allylphenol derivatives with aryl triflates to generate a wide range of functionalized 2,3-dihydrobenzofurans in good yields and diastereoselectivities (up to > 20:1). Use of newly developed reaction conditions that promote anti-heteropalladation of the alkene was essential in order to generate products in high yield.

Organic Chemistry Frontiers published new progress about 1160556-64-8. 1160556-64-8 belongs to quinuclidine, auxiliary class Mono-phosphine Ligands, name is 2′-(Dicyclohexylphosphino)-N2,N2,N6,N6-tetramethyl-[1,1′-biphenyl]-2,6-diamine, and the molecular formula is C28H41N2P, Computed Properties of 1160556-64-8.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Blaser, Hans Ulrich published the artcileHaving Fun (and Commercial Success) with Josiphos and Related Chiral Ferrocene Based Ligands., Product Details of C28H41N2P, the publication is Helvetica Chimica Acta (2021), 104(1), e2000192, database is CAplus.

The Josiphos ligand family is arguably one of the most versatile classes of chiral ligands with a wide range of applications, including one of the two largest known enantioselective catalytic hydrogenations. In this personal account, we take a look back at the beginning and describe the role Antonio Togni has played to reach this point and the significance of his contributions for the com. success, especially concerning todays ligand business of Solvias. This seems a fitting point in time in light of Antonios statement on his ETH home page that he is working as a professor at this institution since 1992 (a few more months to go), not looking for a job′ and that the three authors have already retired for some time (H. U. B.) or are about to retire soon (B. P., F. S.).

Helvetica Chimica Acta published new progress about 1160556-64-8. 1160556-64-8 belongs to quinuclidine, auxiliary class Mono-phosphine Ligands, name is 2′-(Dicyclohexylphosphino)-N2,N2,N6,N6-tetramethyl-[1,1′-biphenyl]-2,6-diamine, and the molecular formula is C28H41N2P, Product Details of C28H41N2P.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Park, Nathaniel H. published the artcileDesign of New Ligands for the Palladium-Catalyzed Arylation of α-Branched Secondary Amines, SDS of cas: 1160556-64-8, the publication is Angewandte Chemie, International Edition (2015), 54(28), 8259-8262, database is CAplus and MEDLINE.

In Pd-catalyzed C-N cross-coupling reactions, α-branched secondary amines are difficult coupling partners and the desired products are often produced in low yields. In order to provide a robust method for accessing N-aryl α-branched tertiary amines, new catalysts have been designed to suppress undesired side reactions often encountered when these amine nucleophiles are used. These advances enabled the arylation of a wide array of sterically encumbered amines, highlighting the importance of rational ligand design in facilitating challenging Pd-catalyzed cross-coupling reactions.

Angewandte Chemie, International Edition published new progress about 1160556-64-8. 1160556-64-8 belongs to quinuclidine, auxiliary class Mono-phosphine Ligands, name is 2′-(Dicyclohexylphosphino)-N2,N2,N6,N6-tetramethyl-[1,1′-biphenyl]-2,6-diamine, and the molecular formula is C28H41N2P, SDS of cas: 1160556-64-8.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider