Category: 1214711-48-4

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 1214711-48-4, is researched, Molecular C18H13BCl3F4N3O, about Asymmetric NHC-catalyzed synthesis of α-fluoroamides from readily accessible α-fluoroenals, the main research direction is enantioselective alpha fluoroamide preparation unsaturated aldehyde amine hydrochloride; diastereoselective alpha fluoroamide synthesis enantioenriched amine alpha fluoroenal reactant; nitrogen heterocyclic carbene catalyst redox amidation alpha fluoroamide preparation; amide functionalization amine fluorohydrin preparation enantioenrichment retention.Application In Synthesis of (5aS,10bR)-2-(2,4,6-Trichlorophenyl)-4,5a,6,10b-tetrahydro-2H-indeno[2,1-b][1,2,4]triazolo[4,3-d][1,4]oxazin-11-ium tetrafluoroborate.

The scope of the NHC-redox amidation has been expanded to include a variety of α,β-unsaturated aldehydes, including α-fluoro α,β-unsaturated aldehydes, which give rise to enantioenriched α-fluoroamides in good to excellent yield and enantioselectivity (up to 97% ee). Enantioenriched amines may be elaborated to either diastereomer of the product in high diastereoselectivity (up to 99 : 1). Functionalization of the amide products to amines and fluorohydrins is also demonstrated with retention of enantioenrichment at the fluorine stereocenter.

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Quinuclidine – Wikipedia,
Quinuclidine | C7H13N | ChemSpider

SDS of cas: 1214711-48-4. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: (5aS,10bR)-2-(2,4,6-Trichlorophenyl)-4,5a,6,10b-tetrahydro-2H-indeno[2,1-b][1,2,4]triazolo[4,3-d][1,4]oxazin-11-ium tetrafluoroborate, is researched, Molecular C18H13BCl3F4N3O, CAS is 1214711-48-4, about N-Heterocyclic Carbene Catalyzed Dynamic Kinetic Resolution of Pyranones. Author is Zhao, Changgui; Li, Fangyi; Wang, Jian.

The dynamic kinetic resolution of 6-hydroxypyranones I [R1 = H, R2 = H, Me, Et, n-Pr, i-Pr, H2C:CHCH2CH2, t-BuSiMe2OCH2; R1 = R2 = Me, Et, cyclopropyl, Ph; R1R2 = (CH2)3, CH2OCH2, etc.; R3 = H, Me, PhCH2CH2; R4 = H, Me, Et, PhCH2CH2, PhCH2OCH2; R3R4 = (CH2)3, (CH2)4] with enals R5CH:CHCHO (R5 = cyclohexyl, Ph, 4-MeOC6H4, etc.) or alkynals R5CCCHO (R5 = 4-MeOC6H4, cyclopentyl, n-octyl, etc.) through an asym. redox esterification was catalyzed by a chiral N-heterocyclic carbene. The resulting esters II were obtained in good to high yields and with high levels of enantio- and diastereocontrol. The reaction products were further derivatized to obtain functionalized sugar derivatives and natural products.

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Quinuclidine – Wikipedia,
Quinuclidine | C7H13N | ChemSpider

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (5aS,10bR)-2-(2,4,6-Trichlorophenyl)-4,5a,6,10b-tetrahydro-2H-indeno[2,1-b][1,2,4]triazolo[4,3-d][1,4]oxazin-11-ium tetrafluoroborate( cas:1214711-48-4 ) is researched.Product Details of 1214711-48-4.Wu, Zijun; Wang, Jian published the article 《Enantioselective Medium-Ring Lactone Synthesis through an NHC-Catalyzed Intramolecular Desymmetrization of Prochiral 1,3-Diols》 about this compound( cas:1214711-48-4 ) in ACS Catalysis. Keywords: enantioselective cyclization intramol desymmetrization prochiral diol heterocyclic carbene catalyst; lactone preparation. Let’s learn more about this compound (cas:1214711-48-4).

A highly enantioselective intramol. annulation reaction of 1,3-diols catalyzed by a triazolium N-heterocyclic carbene (NHC) precatalyst is disclosed, affording the corresponding medium-sized lactones in moderate to good yields with high enantioselectivities. It is worth noting that this compatible catalytic system was successfully applied to assemble a broad range of chiral medium-sized lactones, including ones with eight-, nine-, ten-, eleven-, and twelve-membered rings.

I hope my short article helps more people learn about this compound((5aS,10bR)-2-(2,4,6-Trichlorophenyl)-4,5a,6,10b-tetrahydro-2H-indeno[2,1-b][1,2,4]triazolo[4,3-d][1,4]oxazin-11-ium tetrafluoroborate)Product Details of 1214711-48-4. Apart from the compound(1214711-48-4), you can read my other articles to know other related compounds.

Reference:
Quinuclidine – Wikipedia,
Quinuclidine | C7H13N | ChemSpider

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (5aS,10bR)-2-(2,4,6-Trichlorophenyl)-4,5a,6,10b-tetrahydro-2H-indeno[2,1-b][1,2,4]triazolo[4,3-d][1,4]oxazin-11-ium tetrafluoroborate( cas:1214711-48-4 ) is researched.Application In Synthesis of (5aS,10bR)-2-(2,4,6-Trichlorophenyl)-4,5a,6,10b-tetrahydro-2H-indeno[2,1-b][1,2,4]triazolo[4,3-d][1,4]oxazin-11-ium tetrafluoroborate.Lin, Qiqiao; Li, Yuanzhen; Das, Deb Kumar; Zhang, Guoxiang; Zhao, Zhifei; Yang, Shuang; Fang, Xinqiang published the article 《N-Heterocyclic carbene-catalyzed desymmetrization of functionalized 1,4-dienes via Stetter Reaction》 about this compound( cas:1214711-48-4 ) in Chemical Communications (Cambridge, United Kingdom). Keywords: desymmetrization diene Stetter reaction heterocyclic carbene catalyst; asym desymmetrization diene heterocyclic carbene catalyst; ketone cyclic enantioselective synthesis; Stetter umpolung reaction asym desymmetrization diene. Let’s learn more about this compound (cas:1214711-48-4).

The asym. desymmetrization of 1,4-dienes via chiral N-heterocyclic carbene catalyzed Stetter-type umpolung reaction was demonstrated. A variety of differently substituted dienes were tolerated very well, affording cyclic ketones with two consecutive stereogenic centers (including one quaternary carbon) in moderate to high yields and with high to excellent enantioselectivities. This work expanded both reaction types of catalytic diene desymmetrizations and substrate diversity in NHC catalyzed desym. transformations.

From this literature《N-Heterocyclic carbene-catalyzed desymmetrization of functionalized 1,4-dienes via Stetter Reaction》,we know some information about this compound(1214711-48-4)Application In Synthesis of (5aS,10bR)-2-(2,4,6-Trichlorophenyl)-4,5a,6,10b-tetrahydro-2H-indeno[2,1-b][1,2,4]triazolo[4,3-d][1,4]oxazin-11-ium tetrafluoroborate, but this is not all information, there are many literatures related to this compound(1214711-48-4).

Reference:
Quinuclidine – Wikipedia,
Quinuclidine | C7H13N | ChemSpider

HPLC of Formula: 1214711-48-4. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: (5aS,10bR)-2-(2,4,6-Trichlorophenyl)-4,5a,6,10b-tetrahydro-2H-indeno[2,1-b][1,2,4]triazolo[4,3-d][1,4]oxazin-11-ium tetrafluoroborate, is researched, Molecular C18H13BCl3F4N3O, CAS is 1214711-48-4, about Enantioselective Medium-Ring Lactone Synthesis through an NHC-Catalyzed Intramolecular Desymmetrization of Prochiral 1,3-Diols. Author is Wu, Zijun; Wang, Jian.

A highly enantioselective intramol. annulation reaction of 1,3-diols catalyzed by a triazolium N-heterocyclic carbene (NHC) precatalyst is disclosed, affording the corresponding medium-sized lactones in moderate to good yields with high enantioselectivities. It is worth noting that this compatible catalytic system was successfully applied to assemble a broad range of chiral medium-sized lactones, including ones with eight-, nine-, ten-, eleven-, and twelve-membered rings.

There is still a lot of research devoted to this compound(SMILES：ClC1=C(N2N=C3[N+]([C@@]4([H])[C@@](CC5=C4C=CC=C5)([H])OC3)=C2)C(Cl)=CC(Cl)=C1.F[B-](F)(F)F)HPLC of Formula: 1214711-48-4, and with the development of science, more effects of this compound(1214711-48-4) can be discovered.

Reference:
Quinuclidine – Wikipedia,
Quinuclidine | C7H13N | ChemSpider

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: (5aS,10bR)-2-(2,4,6-Trichlorophenyl)-4,5a,6,10b-tetrahydro-2H-indeno[2,1-b][1,2,4]triazolo[4,3-d][1,4]oxazin-11-ium tetrafluoroborate, is researched, Molecular C18H13BCl3F4N3O, CAS is 1214711-48-4, about Dynamic Kinetic Resolution Enabled by Intramolecular Benzoin Reaction: Synthetic Applications and Mechanistic Insights.Electric Literature of C18H13BCl3F4N3O.

The highly enantio-, diastereo-, and regioselective dynamic kinetic resolution of β-ketoesters and 1,3-diketones was achieved via a chiral N-heterocyclic carbene catalyzed intramol. cross-benzoin reaction. A variety of tetralone derivatives bearing two contiguous stereocenters and multiple functionalities were liberated in moderate to excellent yields and with high levels of stereoselectivity (>95% ee and >20:1 dr in most cases). In addition, the excellent regioselectivity control for aryl/alkyl 1,3-diketones, and the superior electronic differentiation of 1,3-diarylketones were highlighted. Moreover, a set of new mechanistic rationale that differs with the currently widely accepted understanding of intramol. benzoin reactions was established to demonstrate the superior preference of benzoin over aldol transformation. A coexistence of competitive aldol and benzoin reactions was detected, but a retro-aldol-irreversible benzoin process performs a vital role in the generation of predominant benzoin products. The most essential role of an N-electron-withdrawing substituent in triazolium catalysts was revealed to be accelerating the rate of the benzoin transformation, rather than suppressing the aldol process through reducing the inherent basicity of the catalyst.

There is still a lot of research devoted to this compound(SMILES：ClC1=C(N2N=C3[N+]([C@@]4([H])[C@@](CC5=C4C=CC=C5)([H])OC3)=C2)C(Cl)=CC(Cl)=C1.F[B-](F)(F)F)Electric Literature of C18H13BCl3F4N3O, and with the development of science, more effects of this compound(1214711-48-4) can be discovered.

Reference:
Quinuclidine – Wikipedia,
Quinuclidine | C7H13N | ChemSpider

Xu, Weici; Li, Yuanzhen; Liu, Rui; Yang, Shuang; Liu, Jian; Fang, Xinqiang published an article about the compound: (5aS,10bR)-2-(2,4,6-Trichlorophenyl)-4,5a,6,10b-tetrahydro-2H-indeno[2,1-b][1,2,4]triazolo[4,3-d][1,4]oxazin-11-ium tetrafluoroborate( cas:1214711-48-4,SMILESS:ClC1=C(N2N=C3[N+]([C@@]4([H])[C@@](CC5=C4C=CC=C5)([H])OC3)=C2)C(Cl)=CC(Cl)=C1.F[B-](F)(F)F ).Application of 1214711-48-4. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:1214711-48-4) through the article.

The successful organocatalytic kinetic resolution of 1,3-diketones with central quaternary stereocenters through the introduction of internal nucleophiles was reported. Two basic resolution modes were established, allowing access to a broad scope of enantioenriched 1,3-diketones with quaternary stereocenters, together with a large variety of tetralone derivatives with vicinal fully substituted carbon centers, and both of them were not easily available via currently known methods. The inherent principles between the different combinations of ketone groups and the resolution patterns were also disclosed. This work constituted a good complementary choice for the construction of 1,3-diketones with quaternary stereogenic centers and provided insightful information for further studies on diketone substrate-mediated intramol. annulations and kinetic resolutions

There is still a lot of research devoted to this compound(SMILES：ClC1=C(N2N=C3[N+]([C@@]4([H])[C@@](CC5=C4C=CC=C5)([H])OC3)=C2)C(Cl)=CC(Cl)=C1.F[B-](F)(F)F)Application of 1214711-48-4, and with the development of science, more effects of this compound(1214711-48-4) can be discovered.

Reference:
Quinuclidine – Wikipedia,
Quinuclidine | C7H13N | ChemSpider

Computed Properties of C18H13BCl3F4N3O. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: (5aS,10bR)-2-(2,4,6-Trichlorophenyl)-4,5a,6,10b-tetrahydro-2H-indeno[2,1-b][1,2,4]triazolo[4,3-d][1,4]oxazin-11-ium tetrafluoroborate, is researched, Molecular C18H13BCl3F4N3O, CAS is 1214711-48-4, about Oxidative Enantioselective α-Fluorination of Aliphatic Aldehydes Enabled by N-Heterocyclic Carbene Catalysis. Author is Li, Fangyi; Wu, Zijun; Wang, Jian.

In the presence of the indenooxazinotriazolium carbene precursor I•BF4-, aliphatic aldehydes such as hydrocinnamaldehydes 4-RC6H4CH2CH2CHO (R = H, Br) underwent chemo- and enantioselective oxidative fluorination with N-fluorobenzenesulfonimide (NFSI) with alcs. such as cyclohexanol to give nonracemic α-fluoroesters such as II in 71-89% yields and in 73-98% ee. II (R = H) was hydrolyzed to its parent acid, converted to an N-benzyl-β-fluoroamine, and reduced to a β-fluoro alc.; II (R = Br) underwent Suzuki coupling to give II (R = Ph).

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Reference:
Quinuclidine – Wikipedia,
Quinuclidine | C7H13N | ChemSpider

Application of 1214711-48-4. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: (5aS,10bR)-2-(2,4,6-Trichlorophenyl)-4,5a,6,10b-tetrahydro-2H-indeno[2,1-b][1,2,4]triazolo[4,3-d][1,4]oxazin-11-ium tetrafluoroborate, is researched, Molecular C18H13BCl3F4N3O, CAS is 1214711-48-4, about Experimental and Computational Gas Phase Acidities of Conjugate Acids of Triazolylidene Carbenes: Rationalizing Subtle Electronic Effects. Author is Niu, Yijie; Wang, Ning; Munoz, Alberto; Xu, Jiahui; Zeng, Hao; Rovis, Tomislav; Lee, Jeehiun K..

In recent years, triazolylidene carbenes have come to the forefront as important organocatalysts for a wide range of reactions. The fundamental properties of these species, however, remain largely unknown. Herein, the gas phase acidities have been measured and calculated for a series of triazolium cations (the conjugate acids of the triazolylidene carbenes) that have not been heretofore examined in vacuo. The results are discussed in the context of these species as catalysts. We find correlations between the gas phase acidity and selectivity in two Umpolung reactions catalyzed by these species; such correlations are the first of their kind. We are able to use these linear correlations to improve reaction enantioselectivity. These results establish the possibility of using these thermochem. properties to predict reactivity in related transformations.

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Reference:
Quinuclidine – Wikipedia,
Quinuclidine | C7H13N | ChemSpider

SDS of cas: 1214711-48-4. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: (5aS,10bR)-2-(2,4,6-Trichlorophenyl)-4,5a,6,10b-tetrahydro-2H-indeno[2,1-b][1,2,4]triazolo[4,3-d][1,4]oxazin-11-ium tetrafluoroborate, is researched, Molecular C18H13BCl3F4N3O, CAS is 1214711-48-4, about N-Heterocyclic Carbene Catalyzed Asymmetric Hydration: Direct Synthesis of α-Protio and α-Deuterio α-Chloro and α-Fluoro Carboxylic Acids.

Asym. hydration of α,α-dichloro aldehydes and α-halo enals via a NHC-catalyzed redox process to yield enantioenriched α-chloro and α-fluoro carboxylic acids is described herein. The developed reaction allows for installation of an α-deuterium to give rise to enantioenriched α-deutero α-halo acids using D2O as the deuteron source.

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Reference:
Quinuclidine – Wikipedia,
Quinuclidine | C7H13N | ChemSpider