Category: 1214711-48-4

Electric Literature of C18H13BCl3F4N3O. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: (5aS,10bR)-2-(2,4,6-Trichlorophenyl)-4,5a,6,10b-tetrahydro-2H-indeno[2,1-b][1,2,4]triazolo[4,3-d][1,4]oxazin-11-ium tetrafluoroborate, is researched, Molecular C18H13BCl3F4N3O, CAS is 1214711-48-4, about Oxyanion Steering and CH-π Interactions as Key Elements in an N-Heterocyclic Carbene-Catalyzed [4 + 2] Cycloaddition. Author is Allen, Scott E.; Mahatthananchai, Jessada; Bode, Jeffrey W.; Kozlowski, Marisa C..

The N-heterocyclic carbene catalyzed [4 + 2] cycloaddition has been shown to give γ,δ-unsaturated δ-lactones in excellent enantio- and diastereoselectivity. However, preliminary computational studies of the geometry of the intermediate enolate rendered ambiguous both the origins of selectivity and the reaction pathway. Here, we show that a concerted, but highly asynchronous, Diels-Alder reaction occurs rather than the stepwise Michael-type or Claisen-type pathways. In addition, two crucial interactions are identified that enable high selectivity: an oxyanion-steering mechanism and a CH-π interaction. The calculations accurately predict the enantioselectivity of a number of N-heterocyclic carbene catalysts in the hetero-Diels-Alder reaction.

Compound(1214711-48-4)Electric Literature of C18H13BCl3F4N3O received a lot of attention, and I have introduced some compounds in other articles, similar to this compound((5aS,10bR)-2-(2,4,6-Trichlorophenyl)-4,5a,6,10b-tetrahydro-2H-indeno[2,1-b][1,2,4]triazolo[4,3-d][1,4]oxazin-11-ium tetrafluoroborate), if you are interested, you can check out my other related articles.

Reference:
Quinuclidine – Wikipedia,
Quinuclidine | C7H13N | ChemSpider

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (5aS,10bR)-2-(2,4,6-Trichlorophenyl)-4,5a,6,10b-tetrahydro-2H-indeno[2,1-b][1,2,4]triazolo[4,3-d][1,4]oxazin-11-ium tetrafluoroborate( cas:1214711-48-4 ) is researched.Recommanded Product: 1214711-48-4.Lin, Qiqiao; Li, Yuanzhen; Das, Deb Kumar; Zhang, Guoxiang; Zhao, Zhifei; Yang, Shuang; Fang, Xinqiang published the article 《N-Heterocyclic carbene-catalyzed desymmetrization of functionalized 1,4-dienes via Stetter Reaction》 about this compound( cas:1214711-48-4 ) in Chemical Communications (Cambridge, United Kingdom). Keywords: desymmetrization diene Stetter reaction heterocyclic carbene catalyst; asym desymmetrization diene heterocyclic carbene catalyst; ketone cyclic enantioselective synthesis; Stetter umpolung reaction asym desymmetrization diene. Let’s learn more about this compound (cas:1214711-48-4).

The asym. desymmetrization of 1,4-dienes via chiral N-heterocyclic carbene catalyzed Stetter-type umpolung reaction was demonstrated. A variety of differently substituted dienes were tolerated very well, affording cyclic ketones with two consecutive stereogenic centers (including one quaternary carbon) in moderate to high yields and with high to excellent enantioselectivities. This work expanded both reaction types of catalytic diene desymmetrizations and substrate diversity in NHC catalyzed desym. transformations.

Compound(1214711-48-4)Recommanded Product: 1214711-48-4 received a lot of attention, and I have introduced some compounds in other articles, similar to this compound((5aS,10bR)-2-(2,4,6-Trichlorophenyl)-4,5a,6,10b-tetrahydro-2H-indeno[2,1-b][1,2,4]triazolo[4,3-d][1,4]oxazin-11-ium tetrafluoroborate), if you are interested, you can check out my other related articles.

Reference:
Quinuclidine – Wikipedia,
Quinuclidine | C7H13N | ChemSpider

Product Details of 1214711-48-4. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: (5aS,10bR)-2-(2,4,6-Trichlorophenyl)-4,5a,6,10b-tetrahydro-2H-indeno[2,1-b][1,2,4]triazolo[4,3-d][1,4]oxazin-11-ium tetrafluoroborate, is researched, Molecular C18H13BCl3F4N3O, CAS is 1214711-48-4, about Divergent Dynamic Kinetic Resolution of a Racemic Mixture of Four Stereoisomers via N-Heterocyclic Carbene Organocatalysis. Author is Vasamsetty, Laxmaiah; Kong, Xiangwen; Meng, Miao; Yang, Shuang; Xu, Weici; Reddy, Pogula Sreekanth; Fang, Xinqiang.

Racemic mixtures of four stereoisomers are easily formed via many fundamental organic transformations, but the direct utilities of these mixtures were less studied and remain large challenges to date. The authors introduce a new method, i.e., divergent dynamic kinetic resolution, to achieve the separation of racemic mixtures of four stereoisomers. The hypothesis was proved by using a N-heterocyclic carbene-catalyzed benzoin reaction, which afforded two separable diastereomeric products bearing three consecutive stereocenters with good to excellent enantioselectivities. The authors believe that this resolution protocol will find applications in more transformations.

Compound(1214711-48-4)Product Details of 1214711-48-4 received a lot of attention, and I have introduced some compounds in other articles, similar to this compound((5aS,10bR)-2-(2,4,6-Trichlorophenyl)-4,5a,6,10b-tetrahydro-2H-indeno[2,1-b][1,2,4]triazolo[4,3-d][1,4]oxazin-11-ium tetrafluoroborate), if you are interested, you can check out my other related articles.

Reference:
Quinuclidine – Wikipedia,
Quinuclidine | C7H13N | ChemSpider

Wheeler, Philip; Vora, Harit U.; Rovis, Tomislav published the article 《Asymmetric NHC-catalyzed synthesis of α-fluoroamides from readily accessible α-fluoroenals》. Keywords: enantioselective alpha fluoroamide preparation unsaturated aldehyde amine hydrochloride; diastereoselective alpha fluoroamide synthesis enantioenriched amine alpha fluoroenal reactant; nitrogen heterocyclic carbene catalyst redox amidation alpha fluoroamide preparation; amide functionalization amine fluorohydrin preparation enantioenrichment retention.They researched the compound: (5aS,10bR)-2-(2,4,6-Trichlorophenyl)-4,5a,6,10b-tetrahydro-2H-indeno[2,1-b][1,2,4]triazolo[4,3-d][1,4]oxazin-11-ium tetrafluoroborate( cas:1214711-48-4 ).Quality Control of (5aS,10bR)-2-(2,4,6-Trichlorophenyl)-4,5a,6,10b-tetrahydro-2H-indeno[2,1-b][1,2,4]triazolo[4,3-d][1,4]oxazin-11-ium tetrafluoroborate. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:1214711-48-4) here.

The scope of the NHC-redox amidation has been expanded to include a variety of α,β-unsaturated aldehydes, including α-fluoro α,β-unsaturated aldehydes, which give rise to enantioenriched α-fluoroamides in good to excellent yield and enantioselectivity (up to 97% ee). Enantioenriched amines may be elaborated to either diastereomer of the product in high diastereoselectivity (up to 99 : 1). Functionalization of the amide products to amines and fluorohydrins is also demonstrated with retention of enantioenrichment at the fluorine stereocenter.

Compound(1214711-48-4)Quality Control of (5aS,10bR)-2-(2,4,6-Trichlorophenyl)-4,5a,6,10b-tetrahydro-2H-indeno[2,1-b][1,2,4]triazolo[4,3-d][1,4]oxazin-11-ium tetrafluoroborate received a lot of attention, and I have introduced some compounds in other articles, similar to this compound((5aS,10bR)-2-(2,4,6-Trichlorophenyl)-4,5a,6,10b-tetrahydro-2H-indeno[2,1-b][1,2,4]triazolo[4,3-d][1,4]oxazin-11-ium tetrafluoroborate), if you are interested, you can check out my other related articles.

Reference:
Quinuclidine – Wikipedia,
Quinuclidine | C7H13N | ChemSpider

Zhao, Changgui; Li, Fangyi; Wang, Jian published the article 《N-Heterocyclic Carbene Catalyzed Dynamic Kinetic Resolution of Pyranones》. Keywords: pyranone hydroxy preparation enantioselective diastereoselective redox esterification alkenal alkynal; ester oxopyranyl asym synthesis; hydroxy pyranone redox esterification dynamic kinetic resolution unsaturated aldehyde; N-heterocyclic carbenes; catalysis; dynamic kinetic resolution; glycosylation; pyranones.They researched the compound: (5aS,10bR)-2-(2,4,6-Trichlorophenyl)-4,5a,6,10b-tetrahydro-2H-indeno[2,1-b][1,2,4]triazolo[4,3-d][1,4]oxazin-11-ium tetrafluoroborate( cas:1214711-48-4 ).Product Details of 1214711-48-4. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:1214711-48-4) here.

The dynamic kinetic resolution of 6-hydroxypyranones I [R1 = H, R2 = H, Me, Et, n-Pr, i-Pr, H2C:CHCH2CH2, t-BuSiMe2OCH2; R1 = R2 = Me, Et, cyclopropyl, Ph; R1R2 = (CH2)3, CH2OCH2, etc.; R3 = H, Me, PhCH2CH2; R4 = H, Me, Et, PhCH2CH2, PhCH2OCH2; R3R4 = (CH2)3, (CH2)4] with enals R5CH:CHCHO (R5 = cyclohexyl, Ph, 4-MeOC6H4, etc.) or alkynals R5CCCHO (R5 = 4-MeOC6H4, cyclopentyl, n-octyl, etc.) through an asym. redox esterification was catalyzed by a chiral N-heterocyclic carbene. The resulting esters II were obtained in good to high yields and with high levels of enantio- and diastereocontrol. The reaction products were further derivatized to obtain functionalized sugar derivatives and natural products.

From this literature《N-Heterocyclic Carbene Catalyzed Dynamic Kinetic Resolution of Pyranones》,we know some information about this compound(1214711-48-4)Product Details of 1214711-48-4, but this is not all information, there are many literatures related to this compound(1214711-48-4).

Reference:
Quinuclidine – Wikipedia,
Quinuclidine | C7H13N | ChemSpider

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (5aS,10bR)-2-(2,4,6-Trichlorophenyl)-4,5a,6,10b-tetrahydro-2H-indeno[2,1-b][1,2,4]triazolo[4,3-d][1,4]oxazin-11-ium tetrafluoroborate( cas:1214711-48-4 ) is researched.Application of 1214711-48-4.Zhao, Changgui; Li, Fangyi; Wang, Jian published the article 《N-Heterocyclic Carbene Catalyzed Dynamic Kinetic Resolution of Pyranones》 about this compound( cas:1214711-48-4 ) in Angewandte Chemie, International Edition. Keywords: pyranone hydroxy preparation enantioselective diastereoselective redox esterification alkenal alkynal; ester oxopyranyl asym synthesis; hydroxy pyranone redox esterification dynamic kinetic resolution unsaturated aldehyde; N-heterocyclic carbenes; catalysis; dynamic kinetic resolution; glycosylation; pyranones. Let’s learn more about this compound (cas:1214711-48-4).

The dynamic kinetic resolution of 6-hydroxypyranones I [R1 = H, R2 = H, Me, Et, n-Pr, i-Pr, H2C:CHCH2CH2, t-BuSiMe2OCH2; R1 = R2 = Me, Et, cyclopropyl, Ph; R1R2 = (CH2)3, CH2OCH2, etc.; R3 = H, Me, PhCH2CH2; R4 = H, Me, Et, PhCH2CH2, PhCH2OCH2; R3R4 = (CH2)3, (CH2)4] with enals R5CH:CHCHO (R5 = cyclohexyl, Ph, 4-MeOC6H4, etc.) or alkynals R5CCCHO (R5 = 4-MeOC6H4, cyclopentyl, n-octyl, etc.) through an asym. redox esterification was catalyzed by a chiral N-heterocyclic carbene. The resulting esters II were obtained in good to high yields and with high levels of enantio- and diastereocontrol. The reaction products were further derivatized to obtain functionalized sugar derivatives and natural products.

From this literature《N-Heterocyclic Carbene Catalyzed Dynamic Kinetic Resolution of Pyranones》,we know some information about this compound(1214711-48-4)Application of 1214711-48-4, but this is not all information, there are many literatures related to this compound(1214711-48-4).

Reference:
Quinuclidine – Wikipedia,
Quinuclidine | C7H13N | ChemSpider

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 1214711-48-4, is researched, SMILESS is ClC1=C(N2N=C3[N+]([C@@]4([H])[C@@](CC5=C4C=CC=C5)([H])OC3)=C2)C(Cl)=CC(Cl)=C1.F[B-](F)(F)F, Molecular C18H13BCl3F4N3OJournal, Article, Chemical Science called Asymmetric NHC-catalyzed synthesis of α-fluoroamides from readily accessible α-fluoroenals, Author is Wheeler, Philip; Vora, Harit U.; Rovis, Tomislav, the main research direction is enantioselective alpha fluoroamide preparation unsaturated aldehyde amine hydrochloride; diastereoselective alpha fluoroamide synthesis enantioenriched amine alpha fluoroenal reactant; nitrogen heterocyclic carbene catalyst redox amidation alpha fluoroamide preparation; amide functionalization amine fluorohydrin preparation enantioenrichment retention.Recommanded Product: (5aS,10bR)-2-(2,4,6-Trichlorophenyl)-4,5a,6,10b-tetrahydro-2H-indeno[2,1-b][1,2,4]triazolo[4,3-d][1,4]oxazin-11-ium tetrafluoroborate.

The scope of the NHC-redox amidation has been expanded to include a variety of α,β-unsaturated aldehydes, including α-fluoro α,β-unsaturated aldehydes, which give rise to enantioenriched α-fluoroamides in good to excellent yield and enantioselectivity (up to 97% ee). Enantioenriched amines may be elaborated to either diastereomer of the product in high diastereoselectivity (up to 99 : 1). Functionalization of the amide products to amines and fluorohydrins is also demonstrated with retention of enantioenrichment at the fluorine stereocenter.

From this literature《Asymmetric NHC-catalyzed synthesis of α-fluoroamides from readily accessible α-fluoroenals》,we know some information about this compound(1214711-48-4)Recommanded Product: (5aS,10bR)-2-(2,4,6-Trichlorophenyl)-4,5a,6,10b-tetrahydro-2H-indeno[2,1-b][1,2,4]triazolo[4,3-d][1,4]oxazin-11-ium tetrafluoroborate, but this is not all information, there are many literatures related to this compound(1214711-48-4).

Reference:
Quinuclidine – Wikipedia,
Quinuclidine | C7H13N | ChemSpider

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called A photoisomerization-coupled asymmetric Stetter reaction: application to the total synthesis of three diastereomers of (-)-cephalimysin A, published in 2013, which mentions a compound: 1214711-48-4, Name is (5aS,10bR)-2-(2,4,6-Trichlorophenyl)-4,5a,6,10b-tetrahydro-2H-indeno[2,1-b][1,2,4]triazolo[4,3-d][1,4]oxazin-11-ium tetrafluoroborate, Molecular C18H13BCl3F4N3O, COA of Formula: C18H13BCl3F4N3O.

The total synthesis of 8-epi-cephalimysin A, 8,9-epi-cephalimysin A and 9-epi-(-)-cephalimysin A is described. This catalytic enantioselective synthesis takes advantage of a novel tandem photoisomerization/Stetter reaction. The approach provides rapid access to the desired spirofuranone lactam core in good yield and excellent enantioselectivity. A late stage oxidation strategy allows for flexible access to three of the four diastereomers of cephalimysin A. Access to the epimers provides further support for the correction of the initially proposed relative stereochem. of cephalimysin A. The title compounds thus formed included 8-epi-cephalimycin A (I) and related substances, (5S,8R,9R)-8-Benzoyl-2-(3E)-3-hexen-1-yl-9-hydroxy-8-methoxy-3-methyl-1-oxa-7-azaspiro[4.4]non-2-ene-4,6-dione cephalimysin A. The synthesis of the target compounds was achieved using (5aR,10bS)-5a,10b-dihydro-2-(2,3,4,5,6-pentafluorophenyl)-4H,6H-indeno[2,1-b][1,2,4]triazolo[4,3-d][1,4]oxazinium, tetrafluoroborate(1-) as catalyst.

From this literature《A photoisomerization-coupled asymmetric Stetter reaction: application to the total synthesis of three diastereomers of (-)-cephalimysin A》,we know some information about this compound(1214711-48-4)COA of Formula: C18H13BCl3F4N3O, but this is not all information, there are many literatures related to this compound(1214711-48-4).

Reference:
Quinuclidine – Wikipedia,
Quinuclidine | C7H13N | ChemSpider

Liu, Yingguo; Majhi, Pankaj Kumar; Song, Runjiang; Mou, Chengli; Hao, Lin; Chai, Huifang; Jin, Zhichao; Chi, Yonggui Robin published an article about the compound: (5aS,10bR)-2-(2,4,6-Trichlorophenyl)-4,5a,6,10b-tetrahydro-2H-indeno[2,1-b][1,2,4]triazolo[4,3-d][1,4]oxazin-11-ium tetrafluoroborate( cas:1214711-48-4,SMILESS:ClC1=C(N2N=C3[N+]([C@@]4([H])[C@@](CC5=C4C=CC=C5)([H])OC3)=C2)C(Cl)=CC(Cl)=C1.F[B-](F)(F)F ).Recommanded Product: (5aS,10bR)-2-(2,4,6-Trichlorophenyl)-4,5a,6,10b-tetrahydro-2H-indeno[2,1-b][1,2,4]triazolo[4,3-d][1,4]oxazin-11-ium tetrafluoroborate. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:1214711-48-4) through the article.

A catalytic dynamic kinetic resolution and asym. acylation reaction of hydroxyphthalides is developed [e.g., o-carboxybenzaldehyde (in equilibrium with hydroxyphthalide) + Me 4-formylbenzoate → I (96%, 98:2 e.r.) in presence of chiral NHC precatalyst]. The reaction involves formation of a carbene catalyst derived chiral acyl azolium intermediate that effectively differentiates the two enantiomers of racemic hydroxyphthalides. The method allows quick access to enantiomerically enriched phthalidyl esters with proven applications in medicine. It also enables asym. modification of natural products and other functional mols. that contain acetal/ketal groups, such as corollosporine and fimbricalyxlactone C.

From this literature《Carbene-Catalyzed Dynamic Kinetic Resolution and Asymmetric Acylation of Hydroxyphthalides and Related Natural Products》,we know some information about this compound(1214711-48-4)Recommanded Product: (5aS,10bR)-2-(2,4,6-Trichlorophenyl)-4,5a,6,10b-tetrahydro-2H-indeno[2,1-b][1,2,4]triazolo[4,3-d][1,4]oxazin-11-ium tetrafluoroborate, but this is not all information, there are many literatures related to this compound(1214711-48-4).

Reference:
Quinuclidine – Wikipedia,
Quinuclidine | C7H13N | ChemSpider