LeValley, Paige J.’s team published research in Chemical Communications (Cambridge, United Kingdom) in 54 | CAS: 1353016-70-2

Chemical Communications (Cambridge, United Kingdom) published new progress about 1353016-70-2. 1353016-70-2 belongs to quinuclidine, auxiliary class Other Aromatic Heterocyclic,Carboxylic acid,Amide,Inhibitor,Inhibitor, name is Dbco-acid, and the molecular formula is C19H15NO3, Formula: C19H15NO3.

LeValley, Paige J. published the artcileDesign of functionalized cyclic peptides through orthogonal click reactions for cell culture and targeting applications, Formula: C19H15NO3, the publication is Chemical Communications (Cambridge, United Kingdom) (2018), 54(50), 6923-6926, database is CAplus and MEDLINE.

An approach for the design of functionalized cyclic peptides is established for use in 3D cell culture and in cell targeting. Sequential orthogonal click reactions, specifically a photoinitiated thiol-ene and strain promoted azide-alkyne cycloaddition, were utilized for peptide cyclization and conjugation relevant for biomaterial and biomedical applications, resp.

Chemical Communications (Cambridge, United Kingdom) published new progress about 1353016-70-2. 1353016-70-2 belongs to quinuclidine, auxiliary class Other Aromatic Heterocyclic,Carboxylic acid,Amide,Inhibitor,Inhibitor, name is Dbco-acid, and the molecular formula is C19H15NO3, Formula: C19H15NO3.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

 

Cheng, Ho Fung’s team published research in Journal of the American Chemical Society in 143 | CAS: 1353016-70-2

Journal of the American Chemical Society published new progress about 1353016-70-2. 1353016-70-2 belongs to quinuclidine, auxiliary class Other Aromatic Heterocyclic,Carboxylic acid,Amide,Inhibitor,Inhibitor, name is Dbco-acid, and the molecular formula is C19H15NO3, Related Products of quinuclidine.

Cheng, Ho Fung published the artcileElectron-Equivalent Valency through Molecularly Well-Defined Multivalent DNA, Related Products of quinuclidine, the publication is Journal of the American Chemical Society (2021), 143(4), 1752-1757, database is CAplus and MEDLINE.

Oligonucleotide-functionalized nanoparticles (NPs), also known as “programmable atom equivalent” (PAEs), have emerged as a class of versatile building blocks for generating colloidal crystals with tailorable structures and properties. Recent studies have shown that, at small size and low DNA grafting d., PAEs can also behave as “electron equivalent” (EEs), roaming through and stabilizing a complementary PAE sublattice. However, it has been challenging to obtain a detailed understanding of EE-PAE interactions and the underlying colloidal metallicity because there is inherent polydispersity in the number of DNA strands on the surfaces of these NPs; thus, the structural uniformity and tailorability of NP-based EEs are somewhat limited. Herein, we report a strategy for synthesizing colloidal crystals where the EEs are templated by small mols., instead of NPs, and functionalized with a precise number of DNA strands. When these molecularly precise EEs are assembled with complementary NP-based PAEs, X-ray scattering and electron microscopy reveal the formation of three distinct “metallic” phases. Importantly, we show that the thermal stability of these crystals is dependent on the number of sticky ends per EE, while lattice symmetry is controlled by the number and orientation of EE sticky ends on the PAEs. Taken together, this work introduces the notion that, unlike conventional electrons, EEs that are mol. in origin can have a defined valency that can be used to influence and guide specific phase formation.

Journal of the American Chemical Society published new progress about 1353016-70-2. 1353016-70-2 belongs to quinuclidine, auxiliary class Other Aromatic Heterocyclic,Carboxylic acid,Amide,Inhibitor,Inhibitor, name is Dbco-acid, and the molecular formula is C19H15NO3, Related Products of quinuclidine.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

 

Akinbobuyi, Babatope’s team published research in Bioorganic & Medicinal Chemistry Letters in 26 | CAS: 1353016-70-2

Bioorganic & Medicinal Chemistry Letters published new progress about 1353016-70-2. 1353016-70-2 belongs to quinuclidine, auxiliary class Other Aromatic Heterocyclic,Carboxylic acid,Amide,Inhibitor,Inhibitor, name is Dbco-acid, and the molecular formula is C19H15NO3, Application In Synthesis of 1353016-70-2.

Akinbobuyi, Babatope published the artcileSynthesis and immunostimulatory activity of substituted TLR7 agonists, Application In Synthesis of 1353016-70-2, the publication is Bioorganic & Medicinal Chemistry Letters (2016), 26(17), 4246-4249, database is CAplus and MEDLINE.

Fifteen new substituted 9-benzyladenines were synthesized as potential TLR7 agonists. These compounds, along with 9 previously reported compounds, were analyzed for TLR7 activity and for the selective stimulation of B cell proliferation. Several functionalized derivatives exhibit significant activity, suggesting their potential for use as vaccine adjuvants.

Bioorganic & Medicinal Chemistry Letters published new progress about 1353016-70-2. 1353016-70-2 belongs to quinuclidine, auxiliary class Other Aromatic Heterocyclic,Carboxylic acid,Amide,Inhibitor,Inhibitor, name is Dbco-acid, and the molecular formula is C19H15NO3, Application In Synthesis of 1353016-70-2.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

 

Chadwick, Ryan C.’s team published research in Synthesis in 46 | CAS: 1353016-70-2

Synthesis published new progress about 1353016-70-2. 1353016-70-2 belongs to quinuclidine, auxiliary class Other Aromatic Heterocyclic,Carboxylic acid,Amide,Inhibitor,Inhibitor, name is Dbco-acid, and the molecular formula is C19H15NO3, Formula: C19H15NO3.

Chadwick, Ryan C. published the artcileScalable synthesis of strained cyclooctyne derivatives, Formula: C19H15NO3, the publication is Synthesis (2014), 46(5), 669-677, 9 pp., database is CAplus.

Modifications to the Popik synthesis of azadibenzocyclooctyne (DIBAC) derivatives are described, which avoids tedious purifications and dramatically improves the yield. A new and analogous route to biarylazacyclooctynone (BARAC) through an amide disconnection was also attempted. The BARAC derivatives prepared were found to be unstable under the conditions employed, undergoing a known rearrangement. Finally, the synthesis of a difluoro-DIBAC derivative with a second-order rate constant intermediate between DIBAC and BARAC derivatives (0.50 M-1) is described. While more difficult to synthesize, this mol. was found to be considerably more stable than any BARAC derivatives that were prepared

Synthesis published new progress about 1353016-70-2. 1353016-70-2 belongs to quinuclidine, auxiliary class Other Aromatic Heterocyclic,Carboxylic acid,Amide,Inhibitor,Inhibitor, name is Dbco-acid, and the molecular formula is C19H15NO3, Formula: C19H15NO3.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

 

McNelles, Stuart A.’s team published research in Macromolecules (Washington, DC, United States) in 51 | CAS: 1353016-70-2

Macromolecules (Washington, DC, United States) published new progress about 1353016-70-2. 1353016-70-2 belongs to quinuclidine, auxiliary class Other Aromatic Heterocyclic,Carboxylic acid,Amide,Inhibitor,Inhibitor, name is Dbco-acid, and the molecular formula is C19H15NO3, Recommanded Product: Dbco-acid.

McNelles, Stuart A. published the artcileQuantitative Characterization of the Molecular Dimensions of Flexible Dendritic Macromolecules in Solution by Pyrene Excimer Fluorescence, Recommanded Product: Dbco-acid, the publication is Macromolecules (Washington, DC, United States) (2018), 51(4), 1586-1590, database is CAplus.

Eight pyrene labeled dendrons (PyLDs) were prepared with a polyester backbone of bis(hydroxymethyl)propionic acid and the monomer and excimer fluorescence decays of the PyLDs were acquired and fitted according to the recently introduced model free anal. (MFA). The average rate constant of pyrene excimer formation <k> retrieved from the MFA of the decays was found to scale as (2N-1)×l3/<LPy2>1.5 where N represents the number of ground-state pyrene labels in a dendrimer where one of the pyrene is already excited, l is the average bond length, and <LPy2> is the average squared end-to-end distance between every two pyrene labels. The remarkable agreement found between these two quantities, namely <k> and (2N-1)×l3/<LPy2>1.5 which were determined exptl. and math., resp., provides strong support to the notion that pyrene excimer fluorescence (PEF) responds to <LPy2> for pyrene labels attached to macromol. constructs. In turn, <LPy2>0.5 can be used as a measure of the dimension of the macromol. object onto which the pyrene labels are covalently attached. Since (2N-1)/<LPy2>1.5 is the local concentration of ground-state pyrenes in the PyLD, the ratio <k>/[(2N-1)/<LPy2>1.5] yields the bimol. rate constant for excimer formation kdiff which was found to equal 5.0 (±0.6)×109 s-1 for the PyLDs. Consequently, this study demonstrates that PEF applied to macromols. yields a quant. measure of their dimension and internal dynamics and since the rate constant of excimer formation is not distance-dependent, provides a much simpler math. alternative to experiments based on fluorescence resonance energy transfer (FRET).

Macromolecules (Washington, DC, United States) published new progress about 1353016-70-2. 1353016-70-2 belongs to quinuclidine, auxiliary class Other Aromatic Heterocyclic,Carboxylic acid,Amide,Inhibitor,Inhibitor, name is Dbco-acid, and the molecular formula is C19H15NO3, Recommanded Product: Dbco-acid.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

 

Chen, Min’s team published research in Biosensors & Bioelectronics in 206 | CAS: 1353016-70-2

Biosensors & Bioelectronics published new progress about 1353016-70-2. 1353016-70-2 belongs to quinuclidine, auxiliary class Other Aromatic Heterocyclic,Carboxylic acid,Amide,Inhibitor,Inhibitor, name is Dbco-acid, and the molecular formula is C19H15NO3, SDS of cas: 1353016-70-2.

Chen, Min published the artcileAntifouling peptides combined with recognizing DNA probes for ultralow fouling electrochemical detection of cancer biomarkers in human bodily fluids, SDS of cas: 1353016-70-2, the publication is Biosensors & Bioelectronics (2022), 114162, database is CAplus and MEDLINE.

Herein, a universal strategy for the construction of highly sensitive and low fouling biosensors was proposed based on antifouling peptides conjugated with recognizing DNA probes. The peptide-DNA conjugate was formed through a reagent-free click reaction between a typical DNA aptamer modified with 5-dibenzocyclooctyne (DBCO) and the designed antifouling peptide terminated with biotin and the azide group at its two ends. With the assistance of streptavidin (SA), the electrochem. biosensor was constructed via immobilization of the straight peptides and peptide-DNA conjugates in sequence onto the electrode surface modified with electrodeposited poly(3,4-ethylenedioxythiophene) (PEDOT) and gold nanoparticles (AuNPs). The prepared biosensor exhibited excellent antifouling performances in various human bodily fluids such as serum, sweat and urine, with a wide linear response range for CA125 from 0.01 U mL-1 to 1000 U mL-1, and a low limit of detection of 0.003 U mL-1. Combining the advantages of the antifouling peptide and recognizing DNA probe, this sensing strategy was capable of assaying CA125 in undiluted human serum, and it also offered a highly promising way for the development of different antifouling biosensors through the conjugation of antifouling peptides with various DNA probes.

Biosensors & Bioelectronics published new progress about 1353016-70-2. 1353016-70-2 belongs to quinuclidine, auxiliary class Other Aromatic Heterocyclic,Carboxylic acid,Amide,Inhibitor,Inhibitor, name is Dbco-acid, and the molecular formula is C19H15NO3, SDS of cas: 1353016-70-2.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

 

Saito, Fumito’s team published research in ACS Chemical Biology in 10 | CAS: 1353016-70-2

ACS Chemical Biology published new progress about 1353016-70-2. 1353016-70-2 belongs to quinuclidine, auxiliary class Other Aromatic Heterocyclic,Carboxylic acid,Amide,Inhibitor,Inhibitor, name is Dbco-acid, and the molecular formula is C19H15NO3, Quality Control of 1353016-70-2.

Saito, Fumito published the artcileCritical Evaluation and Rate Constants of Chemoselective Ligation Reactions for Stoichiometric Conjugations in Water, Quality Control of 1353016-70-2, the publication is ACS Chemical Biology (2015), 10(4), 1026-1033, database is CAplus and MEDLINE.

Chemoselective ligation reactions have contributed immensely to the development of organic synthesis and chem. biol. However, the ligation of stoichiometric amounts of large mols. for applications such as protein-protein conjugates is still challenging. Conjugation reactions need to be fast enough to proceed under dilute conditions and chemoselective in the presence of unprotected functional groups; the starting materials and products must be stable under the reaction conditions. To compare known ligation reactions for their suitability under these conditions, we determined the second-order rate constants of ligation reactions using peptide substrates with unprotected functional groups. The reaction conditions, the chemoselectivity of the reactions, and the stability of the starting materials and products were carefully evaluated. In some cases, the stability could be improved by modifying the substrate structure. These data obtained under the ligation conditions provide a useful guide to choose an appropriate ligation reaction for synthesis of large mols. by covalent ligation reactions of unprotected substrates in water.

ACS Chemical Biology published new progress about 1353016-70-2. 1353016-70-2 belongs to quinuclidine, auxiliary class Other Aromatic Heterocyclic,Carboxylic acid,Amide,Inhibitor,Inhibitor, name is Dbco-acid, and the molecular formula is C19H15NO3, Quality Control of 1353016-70-2.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

 

Thauvin, Cedric’s team published research in Journal of Drug Delivery Science and Technology in 61 | CAS: 1353016-70-2

Journal of Drug Delivery Science and Technology published new progress about 1353016-70-2. 1353016-70-2 belongs to quinuclidine, auxiliary class Other Aromatic Heterocyclic,Carboxylic acid,Amide,Inhibitor,Inhibitor, name is Dbco-acid, and the molecular formula is C6H11BF3KO, Application In Synthesis of 1353016-70-2.

Thauvin, Cedric published the artcileMicrowave-assisted synthesis of self-assembling bi-functionalizable amphiphilic diblock copolymers, Application In Synthesis of 1353016-70-2, the publication is Journal of Drug Delivery Science and Technology (2021), 102255, database is CAplus.

Active biodegradable polymeric materials are a key area of investigation to develop new imaging and treatment modalities. In this study, we sought to develop tailor-made bi-functionalizable amphiphilic diblock copolymers (BFACs) bearing different reactive groups (e.g., azide, alkyne, maleimide, biotin) on both ends. Designed with a linear backbone constituted of poly (lactic acid), a hydrophobic biodegradable polyester, and poly (ethylene glycol), a hydrophilic biocompatible polymer, BFACs can self-assemble in aqueous media. They are synthesized using a straightforward two-step process: a microwave-assisted ring-opening polymerization followed by a Steglich esterification. BFACs are able to keep their micellar state after the functionalization of their reactive groups via covalent linking or strong interactions with different fluorescent dyes. Interestingly, formation of BFACs-based micelles and their double labeling can be performed in one step. Finally, the uptake of functionalized BFACs-based micelles in the cytoplasmic compartments of MCF-7 cells is observed, thereby illustrating the potential of BFACs to be an easy-to-use tool towards fast development of nanoconstructs for therapy, imaging or theranostics.

Journal of Drug Delivery Science and Technology published new progress about 1353016-70-2. 1353016-70-2 belongs to quinuclidine, auxiliary class Other Aromatic Heterocyclic,Carboxylic acid,Amide,Inhibitor,Inhibitor, name is Dbco-acid, and the molecular formula is C6H11BF3KO, Application In Synthesis of 1353016-70-2.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

 

Hodgson, Sabrina M.’s team published research in Biomacromolecules in 18 | CAS: 1353016-70-2

Biomacromolecules published new progress about 1353016-70-2. 1353016-70-2 belongs to quinuclidine, auxiliary class Other Aromatic Heterocyclic,Carboxylic acid,Amide,Inhibitor,Inhibitor, name is Dbco-acid, and the molecular formula is C19H15NO3, Synthetic Route of 1353016-70-2.

Hodgson, Sabrina M. published the artcileReproducible Dendronized PEG Hydrogels via SPAAC Cross-Linking, Synthetic Route of 1353016-70-2, the publication is Biomacromolecules (2017), 18(12), 4054-4059, database is CAplus and MEDLINE.

A common issue with hydrogel formulations is batch-to-batch irreproducibility, originating from poorly-defined polymer precursors. Here, we report the use of dendritic polymer end-groups to address this issue and maintain reproducibility between batches of poly(ethylene glycol) (PEG) hydrogels. Specifically, we synthesized two end-functionalized PEG chains, one with azide-terminated first- and second-generation dendrons, and the other with strained cyclooctynes. The two complementary azide and alkyne polymers react via the Strain-Promoted Alkyne-Azide Cycoladdn. (SPAAC) to produce hydrogels quickly in the absence of addnl. reagents or catalyst, at low polymer concentrations Hydrogels made with first-generation dendrons gelled in minutes and exhibited a small degree of swelling when incubated in PBS buffer at 37°C, while hydrogels made from second-generation dendrons gelled in seconds with almost no swelling upon incubation at 37°C. In both cases, the hydrogels proved reproducible, resulting in identical Young’s Modulus (YM) values from different batches. The hydrogels prepared with second-generation dendrons were seeded with human mesenchymal stem cells (hMSCs), and showed high cell viability, as well as cell spreading over a two-week timeframe. These studies show that the SPAAC hydrogels are non-cytotoxic, and are capable of supporting cell growth.

Biomacromolecules published new progress about 1353016-70-2. 1353016-70-2 belongs to quinuclidine, auxiliary class Other Aromatic Heterocyclic,Carboxylic acid,Amide,Inhibitor,Inhibitor, name is Dbco-acid, and the molecular formula is C19H15NO3, Synthetic Route of 1353016-70-2.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider