Shaw, Subrata’s team published research in Synthesis in 48 | CAS: 162515-68-6

Synthesis published new progress about 162515-68-6. 162515-68-6 belongs to quinuclidine, auxiliary class Thiol,Carboxylic acid,Aliphatic cyclic hydrocarbon, name is 2-(1-(Mercaptomethyl)cyclopropyl)acetic acid, and the molecular formula is C39H35N5O8, Safety of 2-(1-(Mercaptomethyl)cyclopropyl)acetic acid.

Shaw, Subrata published the artcileAsymmetric Catalysis with Iron-Salen Complexes, Safety of 2-(1-(Mercaptomethyl)cyclopropyl)acetic acid, the publication is Synthesis (2016), 48(17), 2768-2780, database is CAplus.

Iron(III)-salen complexes based on a chiral cis-2,5-diaminobicyclo[2.2.2]octane scaffold are used as catalysts for a variety of stereoselective reactions. High enantio- and diastereoselectivities can be achieved with these catalysts in sulfa-Michael conjugate addition to acyclic α,β-unsaturated ketones, in regioselective δ-addition of thiols to acyclic α,β,γ,δ-unsaturated ketones, and in Conia-ene carbocyclization of alkynyl-substituted β-dicarbonyl compounds The use of these chiral iron-salen complexes as catalysts provides a new method for conducting these three important reactions under environmentally sustainable conditions.

Synthesis published new progress about 162515-68-6. 162515-68-6 belongs to quinuclidine, auxiliary class Thiol,Carboxylic acid,Aliphatic cyclic hydrocarbon, name is 2-(1-(Mercaptomethyl)cyclopropyl)acetic acid, and the molecular formula is C39H35N5O8, Safety of 2-(1-(Mercaptomethyl)cyclopropyl)acetic acid.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

 

Cheng, Jin-tao’s team published research in Guangzhou Huagong in 38 | CAS: 162515-68-6

Guangzhou Huagong published new progress about 162515-68-6. 162515-68-6 belongs to quinuclidine, auxiliary class Thiol,Carboxylic acid,Aliphatic cyclic hydrocarbon, name is 2-(1-(Mercaptomethyl)cyclopropyl)acetic acid, and the molecular formula is C6H10O2S, Related Products of quinuclidine.

Cheng, Jin-tao published the artcileSynthesis of 1-(mercaptomethyl)cyclopropane acetic acid, Related Products of quinuclidine, the publication is Guangzhou Huagong (2010), 38(6), 92-93, database is CAplus.

1-(Mercaptomethyl) cyclopropane acetic acid, the key intermediate of montelukast, was prepared from 1,1-bis(hydroxymethyl)cyclopropane by ring-formation reaction, cyanation reaction, esterification reaction, aldol reaction, and hydrolytic reaction, with 49.5% overall yield.

Guangzhou Huagong published new progress about 162515-68-6. 162515-68-6 belongs to quinuclidine, auxiliary class Thiol,Carboxylic acid,Aliphatic cyclic hydrocarbon, name is 2-(1-(Mercaptomethyl)cyclopropyl)acetic acid, and the molecular formula is C6H10O2S, Related Products of quinuclidine.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

 

White, James D.’s team published research in Chemical Science in 5 | CAS: 162515-68-6

Chemical Science published new progress about 162515-68-6. 162515-68-6 belongs to quinuclidine, auxiliary class Thiol,Carboxylic acid,Aliphatic cyclic hydrocarbon, name is 2-(1-(Mercaptomethyl)cyclopropyl)acetic acid, and the molecular formula is C9H20Cl2Si, SDS of cas: 162515-68-6.

White, James D. published the artcileIron catalyzed enantioselective sulfa-Michael addition: a four-step synthesis of the anti-asthma agent Montelukast, SDS of cas: 162515-68-6, the publication is Chemical Science (2014), 5(6), 2200-2204, database is CAplus.

A salen ligand based on a chiral cis-2,5-diaminobicyclo[2.2.2]octane scaffold forms an iron(iii) complex with ferric chloride which catalyzed asym. addition of thiols to α,β-unsaturated ketones under mild conditions. The reaction (sulfa-Michael addition) produces β-thioketones in excellent yield and high enantiomeric excess from a wide range of aliphatic and aromatic thiols using chalcones and other conjugated enones as Michael acceptors. With α-substituted α,β-unsaturated ketones as acceptors, the addition showed strong preference (typically >50 : 1) for the syn diastereomer over the anti product. An asym. synthesis of (R)-Montelukast, the sodium salt of which is the com. anti-asthma drug Singulair, was devised using conjugate addition of a thiol catalyzed by our iron(III)-salen complex to an α,β-unsaturated ketone synthesized in a four-component, one-pot tandem Michael-aldol condensation. The reaction sequence to (R)-Montelukast proceeded in 72% overall yield over four steps from com. available materials. A mechanism for our catalyzed asym. sulfa-Michael addition was advance which coordinates the enone acceptor to the metal center of the iron-salen complex in an open lower quadrant under the bicyclic scaffold, thereby exposing only the si face of the double bond to attack by the external nucleophilic thiol. Prior internal coordination of the thiol to the metal center of the complex is proposed based on spectroscopic and chem. evidence and leads to activation of the catalyst through a trans ligand effect.

Chemical Science published new progress about 162515-68-6. 162515-68-6 belongs to quinuclidine, auxiliary class Thiol,Carboxylic acid,Aliphatic cyclic hydrocarbon, name is 2-(1-(Mercaptomethyl)cyclopropyl)acetic acid, and the molecular formula is C9H20Cl2Si, SDS of cas: 162515-68-6.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

 

Tang, Yitian’s team published research in ChemCatChem in 12 | CAS: 162515-68-6

ChemCatChem published new progress about 162515-68-6. 162515-68-6 belongs to quinuclidine, auxiliary class Thiol,Carboxylic acid,Aliphatic cyclic hydrocarbon, name is 2-(1-(Mercaptomethyl)cyclopropyl)acetic acid, and the molecular formula is C6H12N2O, Formula: C6H10O2S.

Tang, Yitian published the artcileEfficient Synthesis of γ-Lactones by Cobalt-Catalyzed Carbonylative Ring Expansion of Oxetanes under Syngas Atmosphere, Formula: C6H10O2S, the publication is ChemCatChem (2020), 12(23), 5898-5902, database is CAplus.

A practical route from oxetanes or thietanes to γ-(thio)butyrolactones via solvated-proton-assisted cobalt-catalyzed carbonylative ring expansion under syngas atm. were reported. A wide variety of γ-(thio)butyrolactones were afforded in a good to excellent yields. The versatility of this method were well demonstrated in the synthesis of intermediates towards the natural product Arctigenin as well as the pharmaceuticals Baclofen and Montelukast. The observed promoting effect of glycol ether solvent were rationally interpreted.

ChemCatChem published new progress about 162515-68-6. 162515-68-6 belongs to quinuclidine, auxiliary class Thiol,Carboxylic acid,Aliphatic cyclic hydrocarbon, name is 2-(1-(Mercaptomethyl)cyclopropyl)acetic acid, and the molecular formula is C6H12N2O, Formula: C6H10O2S.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

 

Qiu, Wenting’s team published research in Chinese Journal of Chemistry in 39 | CAS: 162515-68-6

Chinese Journal of Chemistry published new progress about 162515-68-6. 162515-68-6 belongs to quinuclidine, auxiliary class Thiol,Carboxylic acid,Aliphatic cyclic hydrocarbon, name is 2-(1-(Mercaptomethyl)cyclopropyl)acetic acid, and the molecular formula is C6H10O2S, Product Details of C6H10O2S.

Qiu, Wenting published the artcileA Mild, General, Metal-Free Method for Desulfurization of Thiols and Disulfides Induced by Visible-Light, Product Details of C6H10O2S, the publication is Chinese Journal of Chemistry (2021), 39(5), 1255-1258, database is CAplus.

A visible-light-induced metal-free desulfurization method for thiols and disulfides was explored. This radical desulfurization featured mild conditions, robustness, and excellent functionality compatibility. It was successfully applied not only to the desulfurization of small mols., but also to peptides.

Chinese Journal of Chemistry published new progress about 162515-68-6. 162515-68-6 belongs to quinuclidine, auxiliary class Thiol,Carboxylic acid,Aliphatic cyclic hydrocarbon, name is 2-(1-(Mercaptomethyl)cyclopropyl)acetic acid, and the molecular formula is C6H10O2S, Product Details of C6H10O2S.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

 

Silverberg, Lee J.’s team published research in International Journal of Chemistry (Toronto, ON, Canada) in 7 | CAS: 162515-68-6

International Journal of Chemistry (Toronto, ON, Canada) published new progress about 162515-68-6. 162515-68-6 belongs to quinuclidine, auxiliary class Thiol,Carboxylic acid,Aliphatic cyclic hydrocarbon, name is 2-(1-(Mercaptomethyl)cyclopropyl)acetic acid, and the molecular formula is C10H16Br3N, Product Details of C6H10O2S.

Silverberg, Lee J. published the artcileSynthesis and spectroscopic properties of 2,3-diphenyl-1,3-thiaza-4-one heterocycles, Product Details of C6H10O2S, the publication is International Journal of Chemistry (Toronto, ON, Canada) (2015), 7(2), 150-162, database is CAplus.

Synthetic and spectroscopic data (1H NMR, 13C NMR, IR, UV/Vis) for a series of six 2,3-diphenyl-1,3-thiaza-4-one heterocycles which differed in ring size and substitution was reported. The results showed that there are significant differences in spectroscopic signals common to all six compounds Distinctions was made among the compounds using the IR absorbance of the C4 carbonyl and the 1H NMR signal at C2, and to a lesser extent the 13C NMR signal at C4 and the UV/Vis spectrum.

International Journal of Chemistry (Toronto, ON, Canada) published new progress about 162515-68-6. 162515-68-6 belongs to quinuclidine, auxiliary class Thiol,Carboxylic acid,Aliphatic cyclic hydrocarbon, name is 2-(1-(Mercaptomethyl)cyclopropyl)acetic acid, and the molecular formula is C10H16Br3N, Product Details of C6H10O2S.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

 

Rawat, Ajay Singh’s team published research in Organic Process Research & Development in 17 | CAS: 162515-68-6

Organic Process Research & Development published new progress about 162515-68-6. 162515-68-6 belongs to quinuclidine, auxiliary class Thiol,Carboxylic acid,Aliphatic cyclic hydrocarbon, name is 2-(1-(Mercaptomethyl)cyclopropyl)acetic acid, and the molecular formula is C6H10O2S, Related Products of quinuclidine.

Rawat, Ajay Singh published the artcileSynthesis of Donepezil Hydrochloride via Chemoselective Hydrogenation, Related Products of quinuclidine, the publication is Organic Process Research & Development (2013), 17(12), 1617, database is CAplus.

A simple and highly chemoselective and cost-effective process for the synthesis of Donepezil 1 has been developed for com. production In the process, the exocyclic double bond is mainly targeted for catalytic hydrogenation in the presence of an N-benzyl group using sulfur, nitrogen, and phosphorous catalyst modifiers. In some cases, catalytic hydrogenation with Pd on charcoal also produced an undesired side product along with the main product due to over reduction Removal of these impurities by crystallization, column chromatog., or other means of purification makes the process tedious and lengthy, and sometimes it is difficult to achieve the impurity limit as per International Conference on Harmonisation (ICH) guidelines for active pharmaceutical ingredients. In the present investigation we report the synthesis of Donepezil 1 in pure form wherein the debenzyl impurity is within the acceptable limits.

Organic Process Research & Development published new progress about 162515-68-6. 162515-68-6 belongs to quinuclidine, auxiliary class Thiol,Carboxylic acid,Aliphatic cyclic hydrocarbon, name is 2-(1-(Mercaptomethyl)cyclopropyl)acetic acid, and the molecular formula is C6H10O2S, Related Products of quinuclidine.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

 

Yennawar, Hemant P.’s team published research in Acta Crystallographica, Section E: Structure Reports Online in 69 | CAS: 162515-68-6

Acta Crystallographica, Section E: Structure Reports Online published new progress about 162515-68-6. 162515-68-6 belongs to quinuclidine, auxiliary class Thiol,Carboxylic acid,Aliphatic cyclic hydrocarbon, name is 2-(1-(Mercaptomethyl)cyclopropyl)acetic acid, and the molecular formula is C28H18O4, Category: quinuclidine.

Yennawar, Hemant P. published the artcile6,7-Diphenyl-5-thia-7-azaspiro[2.6]nonan-8-one, Category: quinuclidine, the publication is Acta Crystallographica, Section E: Structure Reports Online (2013), 69(11), o1659, database is CAplus and MEDLINE.

The asym. unit of the title compound, C19H19NOS, contains two independent mols. (A and B), in both of which the 1,3-thiazepan-4-one ring adopts a chair-type conformation. The dihedral angles between the two Ph rings are 65.28(8) and 60.31(9)° for mols. A and B, resp. In the crystal, mols. are linked by weak C-H···O interactions, resulting in a three-dimensional network. Crystallog. data and at. coordinates are given.

Acta Crystallographica, Section E: Structure Reports Online published new progress about 162515-68-6. 162515-68-6 belongs to quinuclidine, auxiliary class Thiol,Carboxylic acid,Aliphatic cyclic hydrocarbon, name is 2-(1-(Mercaptomethyl)cyclopropyl)acetic acid, and the molecular formula is C28H18O4, Category: quinuclidine.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

 

Baddam, Sudhakar Reddy’s team published research in Chemistry & Biology Interface in 4 | CAS: 162515-68-6

Chemistry & Biology Interface published new progress about 162515-68-6. 162515-68-6 belongs to quinuclidine, auxiliary class Thiol,Carboxylic acid,Aliphatic cyclic hydrocarbon, name is 2-(1-(Mercaptomethyl)cyclopropyl)acetic acid, and the molecular formula is C6H10O2S, Name: 2-(1-(Mercaptomethyl)cyclopropyl)acetic acid.

Baddam, Sudhakar Reddy published the artcileZinc triflate catalyzed synthesis of thioethers, Name: 2-(1-(Mercaptomethyl)cyclopropyl)acetic acid, the publication is Chemistry & Biology Interface (2014), 4(2), 131-136, 6 pp., database is CAplus.

Zinc triflate-catalyzed aralkylation of thiols using various substituted benzylic alcs. was developed for the synthesis of thioether (sulfide) derivatives This procedure presents a greener approach for the synthesis of sulfides.

Chemistry & Biology Interface published new progress about 162515-68-6. 162515-68-6 belongs to quinuclidine, auxiliary class Thiol,Carboxylic acid,Aliphatic cyclic hydrocarbon, name is 2-(1-(Mercaptomethyl)cyclopropyl)acetic acid, and the molecular formula is C6H10O2S, Name: 2-(1-(Mercaptomethyl)cyclopropyl)acetic acid.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider