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INDOLONES USEFUL AS SEROTONERGIC AGENTS

This invention relates to compounds of the formula: STR1 which are useful as 5-HT 4 agonists or antagonists and 5-HT 3 antagonists.

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Reference£º
Quinuclidine – Wikipedia,
Quinuclidine | C7H13N | ChemSpider

Simple exploration of Quinuclidin-4-ylmethanamine

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Pleuromutilin derivatives as antimicrobials

The present invention relates to pleuromutilin derivatives, to processes for their preparation, to pharmaceutical compositions containing them and to their use in medical therapy, particularly antibacterial therapy.

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Quinuclidine – Wikipedia,
Quinuclidine | C7H23N | ChemSpider

Extracurricular laboratory:new discovery of Quinuclidin-4-ylmethanamine

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 67496-78-0, and how the biochemistry of the body works.Computed Properties of C8H16N2

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2 – Substituted cephem compound-containing pharmaceutical composition (by machine translation)

PROBLEM TO BE SOLVED: To provide a cephem compound which has a strong antimicrobial activity, in particular effective against various beta-lactamase producing Gram negative bacteria, and a composition comprising the compound.SOLUTION: The present invention provides a pharmaceutical composition comprising a compound represented by formula (I), an ester at a carboxyl group, an amino-protected compound when the amino is present on a ring in the 7-side chain, or a pharmaceutically acceptable salt thereof.

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Reference£º
Quinuclidine – Wikipedia,
Quinuclidine | C7H26N | ChemSpider

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Pyrimido[5,4]-dipyrimidines, pharmaceuticals containing them, their use and processes for the preparation thereof

Pyrimido[5,4-d]pyrimidines of the general formula [Figure] which have an inhibitory effect on signal transduction mediated by tyrosine kinases, their use for the treatment of disorders, in particular of oncoses, and their preparation. Exemplary compounds are: 4-[(3-Chloro-4-fluorophenyl)amino]-6-[1-methyl-4-piperidinylamino]pyrimido[5,4-d]pyrimidine, and 4-[(3-Chloro-4-fluorophenyl)amino]-6-[trans-4-dimethyl-aminocycohexylamino]pyrimido[5,4-d]pyrimidine.

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Reference£º
Quinuclidine – Wikipedia,
Quinuclidine | C7H16N | ChemSpider

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CEPHEM COMPOUND HAVING PSEUDO-CATECHOL GROUP

A compound of the formula: wherein X is ?N?, ?CH?, or the like; W is ?CH2? or the like; U is ?S? or the like; R1 and R2 are each independently hydrogen, halogen, optionally substituted lower alkyl, or the like; Q is a single bond or the like; R3 is hydrogen or the like; Ring A is a 6-membered aromatic heterocyclic group having 1-3 nitrogen atoms; each R4 is independently hydrogen, halogen, or the like; m is an integer from 0 to 2; G is ?C(?O)? or the like; D is a single bond, ?NH?, or the like; and E is a cyclic quaternary ammonium group, or an ester, a protected compound at the amino on the ring in the 7-side chain, a pharmaceutically acceptable salt, or a solvate thereof.

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Quinuclidine – Wikipedia,
Quinuclidine | C7H25N | ChemSpider

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CEPHEM DERIVATIVE HAVING CATECHOL GROUP

A compound represented by formula (I) or a pharmaceutically acceptable salt thereof wherein A represents a group represented by one of formulae (i)-(iii); B represents a group represented by formula (v) or (vi); and E represents a substituted or unsubstituted heterocyclic group having a cationic nitrogen atom.

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Reference£º
Quinuclidine – Wikipedia,
Quinuclidine | C7H24N | ChemSpider

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Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about is helpful to your research. Reference of 67496-78-0

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BRIDGED, BICYCLIC HETEROCYCLIC OR SPIRO BICYCLIC HETEROCYCLIC DERIVATIVES OF PYRAZOLO[1,5-A]PYRIMIDINES, METHODS FOR PREPARATION AND USES THEREOF

Compounds of formula A: Formula (1) pharmaceutically acceptable salts thereof are described, which selectively inhibit Raf kinase activity and are useful for treating disorders mediated by Raf kinases.

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Reference£º
Quinuclidine – Wikipedia,
Quinuclidine | C7H18N | ChemSpider

More research is needed about Quinuclidin-4-ylmethanamine

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BENZIMIDAZOLE COMPOUNDS

This invention relates to compounds useful in treating 5-HT. sub.4 and/or 5-HT 3 mediated conditions of the formula STR1 or a pharmaceutically acceptable salt thereof wherein R 1 and R 2 are independently selected from the group consisting of hydrogen, alkoxy, halogen, amino, monoalkylamino, dialkylamino, acylamino and alkylsulfonylamino; R 3 is selected from the group consisting of H, alkyl and cycloalkyl; X is NH or O; and Z is selected from the group consisting of STR2 pharmaceutical compositions including the compounds and a method for treating serotonin mediated conditions with the compositions which act as 5-HT 4 agonists or antagonists and/or 5-HT. sub.3 antagonists.

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Reference£º
Quinuclidine – Wikipedia,
Quinuclidine | C7H14N | ChemSpider

Extended knowledge of Quinuclidin-4-ylmethanamine

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Cefiderocol (S-649266), A new siderophore cephalosporin exhibiting potent activities against Pseudomonas aeruginosa and other gram-negative pathogens including multi-drug resistant bacteria: Structure activity relationship

The structure-activity relationship (SAR) for a novel series of catechol conjugated siderophore cephalosporins is described with their in vitro activities against multi-drug resistant Gram-negative pathogens including Pseudomonas aeruginosa, Acinetobacter baumannii, Stenotrophomonas maltophilia and Enterobacteriaceae. Cefiderocol (3) was one of the best molecules which displayed well-balanced and potent activities against multi-drug resistant Gram-negative pathogens including carbapenem resistant bacteria among the prepared compounds with the modified C-7 side chain and the modified C-3 side chain. Cefiderocol (3) is a highly promising parenteral cephalosporin for the treatment of multi-drug resistant Gram-negative infection.

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Reference£º
Quinuclidine – Wikipedia,
Quinuclidine | C7H27N | ChemSpider

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2? Biaryl amides as novel and subtype selective M1 agonists. Part I: Identification, synthesis, and initial SAR

Biaryl amides were discovered as novel and subtype selective M1 muscarinic acetylcholine receptor agonists. The identification, synthesis, and initial structure-activity relationships that led to compounds 3j and 4c, possessing good M1 agonist potency and intrinsic activity, and subtype selectivity for M1 over M2-5, are described.

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Reference£º
Quinuclidine – Wikipedia,
Quinuclidine | C7H28N | ChemSpider