Tag: 199.1213

Tucker-Schwartz, Alexander K. et al. published their research in Journal of the American Chemical Society in 2011 | CAS: 6530-09-2

3-Aminoquinuclidine dihydrochloride (cas: 6530-09-2) belongs to quinuclidine derivatives. Quinuclidine acts as a catalyst, a chemical building block and is used in organic synthesis. Traditionally, quinuclidine scaffolds can be constructed by second-order nucleophilic substitution (SN2) reaction or condensation reaction of piperidine derivatives. However, most of these reactions are racemic or chiral auxiliary-assisted processes.Electric Literature of C7H16Cl2N2

Thiol-ene Click Reaction as a General Route to Functional Trialkoxysilanes for Surface Coating Applications was written by Tucker-Schwartz, Alexander K.;Farrell, Richard A.;Garrell, Robin L.. And the article was included in Journal of the American Chemical Society in 2011.Electric Literature of C7H16Cl2N2 This article mentions the following:

Functionalized trialkoxysilanes are widely used to modify the surface properties of materials and devices. It will be shown that the photoinitiated radical-based thiol-ene “click” reaction provides a simple and efficient route to diverse trialkoxysilanes. A total of 15 trialkoxysilanes were synthesized by reacting either alkenes with 3-mercaptopropyltrialkoxysilane or thiols with allyltrialkoxysilanes in the presence of a photoinitiator. The functionalized trialkoxysilanes were obtained in quant. to near-quant. yields with high purity. The photochem. reactions can be run neat in standard borosilicate glassware using a low power 15 W blacklight. A wide range of functional groups is tolerated in this approach, and even complex alkenes click with the silane precursors. To demonstrate that these silanes can be used as surface coating agents, several were reacted with iron oxide superparamagnetic nanoparticles and the loadings quantified. The photoinitiated thiol-ene reaction thus offers a facile and efficient method for preparing surface-active functional trialkoxysilanes. In the experiment, the researchers used many compounds, for example, 3-Aminoquinuclidine dihydrochloride (cas: 6530-09-2Electric Literature of C7H16Cl2N2).

3-Aminoquinuclidine dihydrochloride (cas: 6530-09-2) belongs to quinuclidine derivatives. Quinuclidine acts as a catalyst, a chemical building block and is used in organic synthesis. Traditionally, quinuclidine scaffolds can be constructed by second-order nucleophilic substitution (SN2) reaction or condensation reaction of piperidine derivatives. However, most of these reactions are racemic or chiral auxiliary-assisted processes.Electric Literature of C7H16Cl2N2

Referemce:
Quinuclidine – Wikipedia,
Quinuclidine | C7H13N | ChemSpider

 

Rice, Scott et al. published their research in Chemical Communications (Cambridge, United Kingdom) in 2021 | CAS: 6530-09-2

3-Aminoquinuclidine dihydrochloride (cas: 6530-09-2) belongs to quinuclidine derivatives. Quinuclidine acts as a catalyst, a chemical building block and is used in organic synthesis. Asymmetric construction of quinuclidine derivatives has been realized by an iridium-catalyzed allylic dearomatization reaction. The catalytic system, derived from [Ir(cod)Cl]2 and the Feringa ligand, tolerates a broad range of substrates. A large array of quinuclidine derivatives can be obtained under mild conditions in good to excellent yields (68%–96%), diastereoselectivity (up to >20/1 dr), and enantioselectivity (up to >99% ee).Computed Properties of C7H16Cl2N2

Efficient unified synthesis of diverse bridged polycyclic scaffolds using a complexity-generating ‘stitching’ annulation approach was written by Rice, Scott;Cox, Daniel J.;Marsden, Stephen P.;Nelson, Adam. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2021.Computed Properties of C7H16Cl2N2 This article mentions the following:

Regioselective and stereospecific directed C-H arylation of simple amine substrates e.g., exo-2-aminonorbornane, and cyclisation, delivered three-dimensional scaffolds e.g., (1R,3aR,4R,10bS)-2,3,3a,4,5,10b-hexahydro-1,4-methanobenzo[c]cyclopenta[e]azepin-6(1H)-one. The unified approach significantly expanded the range of bridged ring systems that contain both a nitrogen atom and an aromatic ring. In the experiment, the researchers used many compounds, for example, 3-Aminoquinuclidine dihydrochloride (cas: 6530-09-2Computed Properties of C7H16Cl2N2).

3-Aminoquinuclidine dihydrochloride (cas: 6530-09-2) belongs to quinuclidine derivatives. Quinuclidine acts as a catalyst, a chemical building block and is used in organic synthesis. Asymmetric construction of quinuclidine derivatives has been realized by an iridium-catalyzed allylic dearomatization reaction. The catalytic system, derived from [Ir(cod)Cl]2 and the Feringa ligand, tolerates a broad range of substrates. A large array of quinuclidine derivatives can be obtained under mild conditions in good to excellent yields (68%–96%), diastereoselectivity (up to >20/1 dr), and enantioselectivity (up to >99% ee).Computed Properties of C7H16Cl2N2

Referemce:
Quinuclidine – Wikipedia,
Quinuclidine | C7H13N | ChemSpider

 

Manetti, Dina et al. published their research in European Journal of Medicinal Chemistry in 2016 | CAS: 6530-09-2

3-Aminoquinuclidine dihydrochloride (cas: 6530-09-2) belongs to quinuclidine derivatives. Quinuclidine derivatives are also widely utilized as homogeneous or heterogeneous catalysts in various asymmetric processes such as Morita鈥揃aylis鈥揌illman reactions, Sharpless dihydroxylation reactions, and phase-transfer catalytic reactions. Asymmetric construction of quinuclidine derivatives has been realized by an iridium-catalyzed allylic dearomatization reaction. The catalytic system, derived from [Ir(cod)Cl]2 and the Feringa ligand, tolerates a broad range of substrates. A large array of quinuclidine derivatives can be obtained under mild conditions in good to excellent yields (68%鈥?6%), diastereoselectivity (up to >20/1 dr), and enantioselectivity (up to >99% ee).COA of Formula: C7H16Cl2N2

New quinoline derivatives as nicotinic receptor modulators was written by Manetti, Dina;Bellucci, Cristina;Dei, Silvia;Teodori, Elisabetta;Varani, Katia;Spirova, Ekaterina;Kudryavtsev, Denis;Shelukhina, Irina;Tsetlin, Victor;Romanelli, Maria Novella. And the article was included in European Journal of Medicinal Chemistry in 2016.COA of Formula: C7H16Cl2N2 This article mentions the following:

As a continuation of previous work on quinoline derivatives, which showed some preference (2-3 times) for the 伪7 with respect to 伪4尾2 acetylcholine nicotinic receptors (nAChRs),the authors synthesized a series of novel azabicyclic or diazabicyclic compounds carrying a quinoline or isoquinoline ring, with the aim of searching for more selective 伪7 nAChR compounds Radioligand binding studies on 伪7* and 伪4尾2* nAChRs (rat brain homogenate) revealed one compound with a 2-fold higher affinity for the 伪4尾2*-subtype, and four compounds with at least 3-fold higher affinity for 伪7* nAChR. The most promising compound showed a Ki鈭?00 nM and over 10-fold selectivity for 伪7* nAChR. Other compounds at 50 渭M suppressed ion currents induced in the rat 伪4尾2 nAChR and the chimeric nAChR composed of the ligand-binding domain of the chick 伪7 and transmembrane domain of the 伪1 glycine receptor, expressed in Xenopus oocytes. Calcium imaging experiments on the human 伪7 nAChR expressed in the Neuro2a cells and potentiated by PNU-120596 confirmed the antagonistic activity for one compound and on the contrary other compounds were agonists with the EC50 values in the range of 1.0-1.6 渭M. Thus, the introduced modifications allowed us to enhance the selectivity of quinolines towards 伪7 nAChR and to get novel compounds with agonistic activity. The synthesis of the target compounds was achieved by a reaction of 1,4-diazabicyclo[3.2.2]nonane, 1,4-diazabicyclo[3.2.1]octane dihydrochloride, 1-Azabicyclo[2.2.2]octan-3-amine, hydrochloride (1:2) with (bromo)quinoline derivatives, quinolinecarboxylic acid derivatives, isoquinolinecarboxylic acid derivatives The title compounds thus formed included . In the experiment, the researchers used many compounds, for example, 3-Aminoquinuclidine dihydrochloride (cas: 6530-09-2COA of Formula: C7H16Cl2N2).

3-Aminoquinuclidine dihydrochloride (cas: 6530-09-2) belongs to quinuclidine derivatives. Quinuclidine derivatives are also widely utilized as homogeneous or heterogeneous catalysts in various asymmetric processes such as Morita鈥揃aylis鈥揌illman reactions, Sharpless dihydroxylation reactions, and phase-transfer catalytic reactions. Asymmetric construction of quinuclidine derivatives has been realized by an iridium-catalyzed allylic dearomatization reaction. The catalytic system, derived from [Ir(cod)Cl]2 and the Feringa ligand, tolerates a broad range of substrates. A large array of quinuclidine derivatives can be obtained under mild conditions in good to excellent yields (68%鈥?6%), diastereoselectivity (up to >20/1 dr), and enantioselectivity (up to >99% ee).COA of Formula: C7H16Cl2N2

Referemce:
Quinuclidine – Wikipedia,
Quinuclidine | C7H13N | ChemSpider

 

Chen, Shengquan et al. published their research in Yaoxue Xuebao in 1987 | CAS: 6530-09-2

3-Aminoquinuclidine dihydrochloride (cas: 6530-09-2) belongs to quinuclidine derivatives.The reactions of quinuclidine compounds that lead to opening of the 1-azabi-cyclic system at the N-C and C-C bonds to give piperidine derivatives or, via subsequent rearrangements, derivatives of other heterocyclic systems, are correlated. Processes involving the fragmentation of quinuclidines in chemical reactions and under electron impact and reactions involving expansion of the quinuclidine ring and intermediate cleavage of the bicyclic system are examined.聽 Carbamoyl boranes are generally prepared as adducts with tertiary amines, such as trialkyl amines, pyridine, or quinuclidine, via two synthetic approaches based either on amidation of amine-carboxyborane adducts or on hydrolysis of amine-cyanoboranes.Computed Properties of C7H16Cl2N2

Synthesis and neuromuscular blocking activity of symmetrical bis- and poly-quaternary derivatives of quinuclidine and tropine was written by Chen, Shengquan;Yu, Shongtao;Geng, Rongliang;Dan, Zhiyi. And the article was included in Yaoxue Xuebao in 1987.Computed Properties of C7H16Cl2N2 This article mentions the following:

Title compounds e.g., I and II [Z = O, NOH; Z1 = (CH2)6, CH2OCH2; X = Br, Cl] were prepared from quinuclidine or tropine derivatives and their neuromuscular blocking activity was reported. In the experiment, the researchers used many compounds, for example, 3-Aminoquinuclidine dihydrochloride (cas: 6530-09-2Computed Properties of C7H16Cl2N2).

3-Aminoquinuclidine dihydrochloride (cas: 6530-09-2) belongs to quinuclidine derivatives.The reactions of quinuclidine compounds that lead to opening of the 1-azabi-cyclic system at the N-C and C-C bonds to give piperidine derivatives or, via subsequent rearrangements, derivatives of other heterocyclic systems, are correlated. Processes involving the fragmentation of quinuclidines in chemical reactions and under electron impact and reactions involving expansion of the quinuclidine ring and intermediate cleavage of the bicyclic system are examined.聽 Carbamoyl boranes are generally prepared as adducts with tertiary amines, such as trialkyl amines, pyridine, or quinuclidine, via two synthetic approaches based either on amidation of amine-carboxyborane adducts or on hydrolysis of amine-cyanoboranes.Computed Properties of C7H16Cl2N2

Referemce:
Quinuclidine – Wikipedia,
Quinuclidine | C7H13N | ChemSpider

 

Horak, Jeannie et al. published their research in Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences in 2010 | CAS: 6530-09-2

3-Aminoquinuclidine dihydrochloride (cas: 6530-09-2) belongs to quinuclidine derivatives. Quinuclidine exists in a number of naturally occurring compounds, biologically active agents, and privileged catalysts and ligands for asymmetric catalysis. The reactions of quinuclidine compounds that lead to opening of the 1-azabi-cyclic system at the N-C and C-C bonds to give piperidine derivatives or, via subsequent rearrangements, derivatives of other heterocyclic systems, are correlated.Product Details of 6530-09-2

Optimization of a ligand immobilization and azide group endcapping concept via “Click-Chemistry” for the preparation of adsorbents for antibody purification was written by Horak, Jeannie;Hofer, Stefan;Lindner, Wolfgang. And the article was included in Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences in 2010.Product Details of 6530-09-2 This article mentions the following:

This report describes and compares different strategies to deactivate (endcap) epoxide groups and azide groups on bio-chromatog. support surfaces, before and after ligand attachment. Adsorbents possessing epoxide groups were deactivated using acidic hydrolysis or were endcapped with 2-mercaptoethanol or 2-ethanolamine. The influence of surface-bound 2-ethanolamine was demonstrated for the triazine-type affinity adsorbent B14-2LP-FractoAIMs-1, which was tested in combination with the weak anion exchange material 3-aminoquinuclidine-FractoAIMs-3 (AQ-FA3). Azide groups were modified with 2-propargyl alc. using Click-Chem. Besides the conventional one-pot Click reaction, an alternative approach was introduced. This optimized Click protocol was employed (i) for the preparation of the weak anion exchange material AdQ-triazole-Fractogel (AdQ-TRZ-FG) and (ii) for the endcapping of residual azide groups with 3-propargyl alc. Using the new Click reaction protocol the ligand immobilization rate was doubled from 250 to 500 渭mol/g dry adsorbent. Furthermore, the modified support surface was proven to be inert towards the binding of IgG as well as feed impurities. A thorough evaluation of modified surfaces and adsorbents was performed with dynamic binding experiments using cell culture supernatant containing monoclonal human IgG (h-IgG-1). Besides SDS-Page, a recently introduced Protein A-size exclusion HPLC method (PSEC-HPLC) was used to visualize the feed impurity composition and the IgG content of all collected sample fractions in simple PSEC-Plots. A surprising outcome of this study was the irreversible binding of IgG to azide modified surfaces. It was found that organic azide compounds, e.g. 1-azide-3-(2-propen-1-yloxy)-2-propanol (AGE-N3) promote antibody aggregation to a slightly higher extent than the inorganic sodium azide. The possibility that the Hofmeister Series of salt anions may be applicable to predict the properties of the corresponding organic compounds is discussed. In the experiment, the researchers used many compounds, for example, 3-Aminoquinuclidine dihydrochloride (cas: 6530-09-2Product Details of 6530-09-2).

3-Aminoquinuclidine dihydrochloride (cas: 6530-09-2) belongs to quinuclidine derivatives. Quinuclidine exists in a number of naturally occurring compounds, biologically active agents, and privileged catalysts and ligands for asymmetric catalysis. The reactions of quinuclidine compounds that lead to opening of the 1-azabi-cyclic system at the N-C and C-C bonds to give piperidine derivatives or, via subsequent rearrangements, derivatives of other heterocyclic systems, are correlated.Product Details of 6530-09-2

Referemce:
Quinuclidine – Wikipedia,
Quinuclidine | C7H13N | ChemSpider

 

Chen, Shengquan et al. published their research in Yaoxue Xuebao in 1987 | CAS: 6530-09-2

3-Aminoquinuclidine dihydrochloride (cas: 6530-09-2) belongs to quinuclidine derivatives.The reactions of quinuclidine compounds that lead to opening of the 1-azabi-cyclic system at the N-C and C-C bonds to give piperidine derivatives or, via subsequent rearrangements, derivatives of other heterocyclic systems, are correlated. Processes involving the fragmentation of quinuclidines in chemical reactions and under electron impact and reactions involving expansion of the quinuclidine ring and intermediate cleavage of the bicyclic system are examined.  Carbamoyl boranes are generally prepared as adducts with tertiary amines, such as trialkyl amines, pyridine, or quinuclidine, via two synthetic approaches based either on amidation of amine-carboxyborane adducts or on hydrolysis of amine-cyanoboranes.Computed Properties of C7H16Cl2N2

Synthesis and neuromuscular blocking activity of symmetrical bis- and poly-quaternary derivatives of quinuclidine and tropine was written by Chen, Shengquan;Yu, Shongtao;Geng, Rongliang;Dan, Zhiyi. And the article was included in Yaoxue Xuebao in 1987.Computed Properties of C7H16Cl2N2 This article mentions the following:

Title compounds e.g., I and II [Z = O, NOH; Z1 = (CH2)6, CH2OCH2; X = Br, Cl] were prepared from quinuclidine or tropine derivatives and their neuromuscular blocking activity was reported. In the experiment, the researchers used many compounds, for example, 3-Aminoquinuclidine dihydrochloride (cas: 6530-09-2Computed Properties of C7H16Cl2N2).

3-Aminoquinuclidine dihydrochloride (cas: 6530-09-2) belongs to quinuclidine derivatives.The reactions of quinuclidine compounds that lead to opening of the 1-azabi-cyclic system at the N-C and C-C bonds to give piperidine derivatives or, via subsequent rearrangements, derivatives of other heterocyclic systems, are correlated. Processes involving the fragmentation of quinuclidines in chemical reactions and under electron impact and reactions involving expansion of the quinuclidine ring and intermediate cleavage of the bicyclic system are examined.  Carbamoyl boranes are generally prepared as adducts with tertiary amines, such as trialkyl amines, pyridine, or quinuclidine, via two synthetic approaches based either on amidation of amine-carboxyborane adducts or on hydrolysis of amine-cyanoboranes.Computed Properties of C7H16Cl2N2

Referemce:
Quinuclidine – Wikipedia,
Quinuclidine | C7H13N | ChemSpider