Tag: M.W=200-250

Truffault, Robert published the artcileCondensation of halogenated derivatives of benzene with unsaturated hydrocarbons and with halogenated derivatives of the latter under the influence of concentrated sulfuric acid as catalyst, Quality Control of 20029-52-1, the publication is Compt. rend. (1938), 676-8, database is CAplus.

Halogenated benzenes condense with olefins, in the presence of concentrated H₂SO₄, in the same way that benzene does (cf. C. A. 30, 4154.8), yielding p-substituted halogenated benzenes. Cyclohexene and PhCl react to form p-chlorocyclohexylbenzene (I), b₁₆ 134°, d₂₀ 1.070, n_D²⁰ 1.5400; M. R. calculated 56.7, found 57.03. With PhBr the product is p-bromocyclohexylbenzene (II), b₁₆ 146°, d₁₉ 1.289, n_D²⁰ 1.5605; M. R., calculated 59.58, found 60.0. Oxidation of I with CrO₃ gave p-ClC₆H₄CO₂H, m. 236°. The Mg derivative of II reacts with CO₂ to form p-cyclohexylbenzoic acid, m. 200°. Allyl chloride (III) and PhCl react to form p-ClC₆H₄CHMeCHCl (IV), b₁₆ 117°, d₂₁ 1.185, n_D²⁰ 1.538; M. R., calculated 49.9, found 49.9. With PhBr the product is p-BrC₆H₄CHMeCH₂Cl (V), b₁₅ 134-5°, d₂₁ 1.416, n_D²¹ 1.558; M. R., calculated 52.8, found 53.2. The structures of IV and V were assigned on the basis of the structures established for the compounds prepared from C₆H₆ and III, loc. cit. Thus, H₂SO₄ may be used to prepare alkylbenzenes having halogenated side chains, which cannot be obtained in the Friedel-Crafts reaction.

Compt. rend. published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C16H18Br2ClN3O3, Quality Control of 20029-52-1.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Lu, Xiaoxin published the artcileNumerical modeling and experimental characterization of the AC conductivity and dielectric properties of CNT/polymer nanocomposites, Application In Synthesis of 1761-71-3, the publication is Composites Science and Technology (2020), 108150, database is CAplus.

In this work, we proposed a multiscale numerical model to estimate the elec. conductivity and dielec. constants of the CNT/polymer nanocomposites, taking into account the tunneling effect between neighboring CNTs separated at nanoscale and the frequency-dependent dielec. properties of each components. Finite element method was employed to solve the formulations, and the CNTs were modeled by highly conductive line segments in order to avoid the mesh problems. Experiments have been carried out in carbon nanotubes/epoxy nanocomposites in order to compare to the simulation results. The numerical estimations of the elec. conductivity are in good agreement with the exptl. measurement by network analyzers. Moreover, the calculated dielec. permittivity agrees with the exptl. data for the nanocomposites whose CNT content is beyond percolation threshold. Below percolation threshold, the proposed model also works well in the prediction of dielec. constants when the frequency is over 103Hz.

Composites Science and Technology published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C13H26N2, Application In Synthesis of 1761-71-3.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Xiang, Kang published the artcileTunable C-H arylation and acylation of azoles with carboxylic acids by Pd/Cu cooperative catalysis, Product Details of C13H16O2, the publication is Organic Chemistry Frontiers (2021), 8(11), 2543-2550, database is CAplus.

The direct C-H arylation and acylation of azoles with carboxylic acids were achieved through Pd/Cu cooperative catalysis. Various biaryls and biaryl ketones were selectively produced in good to high yields from the same substrates. The key factor of high chemoselectivity was the choice of a suitable phosphine ligand: biaryls were generated selectively with dppp as the ligand, while biaryl ketones were obtained with high selectivity using dpph or Ph₂PCy as the ligand.

Organic Chemistry Frontiers published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C3H6O2, Product Details of C13H16O2.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Li, Yan Mei published the artcileTailored modular assembly derived self-healing polythioureas with largely tunable properties covering plastics, elastomers and fibers, Formula: C13H26N2, the publication is Nature Communications (2022), 13(1), 2633, database is CAplus and MEDLINE.

To impart self-healing polymers largely adjustable dynamicity and mech. performance, here we develop libraries of catalyst-free reversible polythioureas directly from commodity 1,4-phenylene diisothiocyanate and amines via facile click chem. based modular assembly. By using the amine modules with various steric hindrances and flexibilities, the reversible thiourea units acquire triggering temperatures from room temperature to 120 °C. Accordingly, the derived self-healable, recyclable and controlled degradable dynamically crosslinked polythioureas can take effect within wide temperature range. Moreover, mech. properties of the materials can be tuned covering plastics, elastomers and fibers using (i) different assemble modules or (ii) solid-state stretching. Particularly, unidirectional stretching leads to the record-high tensile strength of 266 MPa, while bidirectional stretching provides the materials with biaxial strengths up to over 120 MPa. The mol. mechanism and technol. innovations discussed in this work may benefit promotion and application of self-healing polymers towards greatly diverse demands and scenarios.

Nature Communications published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C13H26N2, Formula: C13H26N2.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Dragovich, Peter S. published the artcileFragment-based design of 3-aminopyridine-derived amides as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT), Recommanded Product: 4-Cyclohexylbenzoic acid, the publication is Bioorganic & Medicinal Chemistry Letters (2014), 24(3), 954-962, database is CAplus and MEDLINE.

The fragment-based identification of two novel and potent biochem. inhibitors of the nicotinamide phosphoribosyltransferase (NAMPT) enzyme is described. These compounds (51 and 63) incorporate an amide moiety derived from 3-aminopyridine, and are thus structurally distinct from other known anti-NAMPT agents. Each exhibits potent inhibition of NAMPT biochem. activity (IC₅₀ = 19 and 15 nM, resp.) as well as robust antiproliferative properties in A2780 cell culture experiments (IC₅₀ = 121 and 99 nM, resp.). However, addnl. biol. studies indicate that only inhibitor 51 exerts its A2780 cell culture effects via a NAMPT-mediated mechanism. The crystal structures of both 51 and 63 in complex with NAMPT are also independently described.

Bioorganic & Medicinal Chemistry Letters published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C13H16O2, Recommanded Product: 4-Cyclohexylbenzoic acid.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Liang, Yumeng published the artcileAcyl Fluorides from Carboxylic Acids, Aldehydes, or Alcohols under Oxidative Fluorination, Formula: C13H16O2, the publication is Organic Letters (2021), 23(3), 847-852, database is CAplus and MEDLINE.

A novel reagent system to obtain acyl fluorides such as benzoyl fluoride, 4-cyclohexylbenzoyl fluoride, dodecanoyl fluoride, etc. directly from three different functional group precursors: carboxylic acids such as benzoic acid, thiophene-2-carboxylic acid, dodecanoic acid, etc. aldehydes such as benzaldehyde, picolinaldehyde, cyclopropanecarboxaldehyde, etc. or alcs. such as benzyl alc., 2-bromonicotinyl alc., 4-bromobenzyl alc., etc. was described. The transformation is achieved via a combination of trichloroisocyanuric acid and cesium fluoride, which facilitates the synthesis of various acyl fluorides in high yield (up to 99%). It can be applied to the late-stage functionalization of natural products and drug mols. that contain a carboxylic acid, an aldehyde, or an alc. group.

Organic Letters published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C13H16O2, Formula: C13H16O2.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Boyarskii, V. P. published the artcileSynthesis of Aromatic Carboxylic Acids by Carbonylation of Aryl Halides in the Presence of Epoxide-Modified Cobalt Carbonyls as Catalysts, Recommanded Product: 4-Cyclohexylbenzoic acid, the publication is Russian Journal of Applied Chemistry (2005), 78(11), 1844-1848, database is CAplus.

A new procedure was developed for synthesis of aromatic and heteroaromatic acids and their derivatives (esters, salts) by carbonylation of the corresponding aryl halides. The acids are selectively formed in high yield under very mild conditions. Highly active catalytic systems, base-containing alc. solutions of cobalt carbonyl modified with epoxides, were used to activate aryl halides.

Russian Journal of Applied Chemistry published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C13H16O2, Recommanded Product: 4-Cyclohexylbenzoic acid.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Qin, Ruixuan published the artcileAlkali ions secure hydrides for catalytic hydrogenation, Application In Synthesis of 1761-71-3, the publication is Nature Catalysis (2020), 3(9), 703-709, database is CAplus.

Catalytic hydrogenation is one of the backbones of the chem. industry. Controlling the reaction behavior of the activated hydrogen species over oxide-supported metal catalysts is essential. Aside from the expected addition to substrates, the activated hydrogen species would also destroy the active structures. Here we show that, with the assistance of alkali cations, the atomically dispersed Ru(III) on Al₂O₃ exhibits enhanced performance in the hydrogenation of a broad range of substrates. The alkali cations facilitate the hydrogenation mediated by heterolytic hydrogen species, which not only restrain the hydride species from migrating to interfacial oxygen, thus suppressing the reduction and aggregation of ruthenium, but also stabilize the neg. charged transition states and intermediates through enhanced Columbic attraction. Distinctively, an inverse H/D isotope effect related to H₂ splitting as the rate-determining step over the atomically dispersed ruthenium-catalyzed hydrogenation is predicted and confirmed.

Nature Catalysis published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C13H26N2, Application In Synthesis of 1761-71-3.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Zhao, Changchun published the artcileInterfacial combination of Ti₃C₂T_x MXene with waterborne epoxy anticorrosive coating, Safety of 4,4-Diaminodicyclohexyl methane, the publication is Applied Surface Science (2022), 150894, database is CAplus.

Interfacial combination of two-dimensional material composite coatings is one of the main factors affecting anti-corrosion performance of coatings. The surface of MXene are usually covered with active groups such as F, O, OH, etc. However, the interactions between active groups and epoxy mols. are still unclear. Here in, the adsorption stability and chem. bond types of Ti₃C₂Tx/epoxy structures with different surface groups were investigated by first-principles calculations The waterborne Ti₃C₂Tx/epoxy composite coatings were prepared by liquid phase blending method. The micro-structures, anticorrosion performance and compactness of the coatings were studied. Based on the theor. calculations, Ti₃C₂Tx shows excellent adsorption stability with epoxy mols., and the Ti₃C₂Tx with OH groups exhibited the best adsorption stability due to the formation of covalent bonds between OH groups and the epoxy groups (or benzene structures). The exptl. results show that, Ti₃C₂Tx nanosheets can disperse uniformly in the coating prepared by the liquid phase blending method. The micro-pores in composite coatings are improved, and the impedance modulus is 2 orders of magnitude much higher than that of pure epoxy coating. In this work, the studies of the adsorption behavior of Ti₃C₂Tx MXene to epoxy groups and benzene structures provide a reliable basis for the subsequent targeted regulation of the interaction between them.

Applied Surface Science published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C10H11FN2O2S, Safety of 4,4-Diaminodicyclohexyl methane.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Han, Jie published the artcileDesign and Synthesis of WJ-Phos, and Application in Cu-Catalyzed Enantioselective Boroacylation of 1,1-Disubstituted Allenes, Computed Properties of 20029-52-1, the publication is ACS Catalysis (2019), 9(8), 6890-6895, database is CAplus.

The highly enantioselective copper-catalyzed three-component boroacylation of 1,1-disubstituted allenes is reported by using a class of chiral ligands (WJ-Phos), delivering various functionalized organoboron compounds bearing an all-carbon stereocenter in moderate to good yields with high enantioselectivities. WJ-Phos is a ferrocene-derived chiral sulfinamide phosphine ligand and can be easily synthesized in gram-scale from readily available starting materials in short steps. The salient features of this reaction include moderate to good yields, high enantioselectivities, gram-scale synthesis, diverse synthetic transformations, and the development of a new chiral ligand.

ACS Catalysis published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C13H16O2, Computed Properties of 20029-52-1.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider