Tag: M.W=200-250

Fan, Zhengning published the artcileVisible-Light-Induced Catalyst-Free Carboxylation of Acylsilanes with Carbon Dioxide, Quality Control of 20029-52-1, the publication is Organic Letters (2021), 23(6), 2303-2307, database is CAplus and MEDLINE.

Intermol. carbon-carbon bond formation between acylsilanes and carbon dioxide (CO₂) was achieved by photoirradiation under catalyst-free conditions. In this reaction, siloxycarbenes generated by photoisomerization of the acylsilanes added to the C=O bond of CO₂ to give α-ketocarboxylates, which underwent hydrolysis to afford α-ketocarboxylic derivatives in good yields. Control experiments suggest that the generated siloxycarbene is likely to be from the singlet state (S₁) of the acylsilane and the addition to CO₂ is not in a concerted manner.

Organic Letters published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C13H16O2, Quality Control of 20029-52-1.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Lai, Chiu-Chun published the artcileSynthesis and properties of low-crystallinity nylon 6 with high transparency and low hygroscopicity containing adipic acid, Safety of 4,4-Diaminodicyclohexyl methane, the publication is Modern Physics Letters B (2020), 34(7/9), 2040005, database is CAplus.

In this research, a series of amorphous nylons 6 were prepared by introducing adipic acid and different structure amines into the copolymerization with caprolactam. The effects including thermal properties, crystallinity, dynamic mech. properties, optical properties, and water absorption of different copolymerization structure and copolymerization ratio on the properties of nylon 6 were investigated. The results show the m.p. and thermal cracking temperature Td 5 of nylon 6 are, resp., between 179°C and 217°C and 278°C to 336°C. Nylon 6 structure introducing a Me side chain is more effective than a meta-benzene ring, a meta-cycloalkyl, and bicycloalkyl groups, so CAMM and CAI have the lowest crystallinity.

Modern Physics Letters B published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C13H26N2, Safety of 4,4-Diaminodicyclohexyl methane.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Xu, Guoyan G. published the artcileExploration on natural product anibamine side chain modification toward development of novel CCR5 antagonists and potential anti-prostate cancer agents, Application In Synthesis of 20029-52-1, the publication is Bioorganic & Medicinal Chemistry Letters (2015), 25(17), 3721-3725, database is CAplus and MEDLINE.

Prostate cancer is one of the leading causes of death among males in the world. Prostate cancer cells have been shown to express upregulated chemokine receptor CCR5, a G protein-coupled receptor (GPCR) that relates to the inflammation process. Anibamine, a natural product containing a pyridine ring and two aliphatic side chains, was shown to carry a binding affinity of 1 μM at CCR5 as an antagonist with potential anticancer activity. However, it is not drug-like according to the Lipinski’s rule of five mainly due to its two long aliphatic side chains. In the effort to improve its drug-like property, a series of anibamine derivatives were designed and synthesized by placement of aromatic side chains through an amide linkage to the pyridine ring. The newly synthesized compounds were tested for their CCR5 affinity and antagonism, and potential antiproliferation activity against prostate cancer cell lines. Basal cytotoxicity was finally studied for compounds showing potent antiproliferation activity. It was found that compounds with hydrophobic substitutions on the aromatic systems seemed to carry more promising CCR5 binding and prostate cancer cell proliferation inhibition activities.

Bioorganic & Medicinal Chemistry Letters published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C7H11N, Application In Synthesis of 20029-52-1.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Zhang, Jie published the artcileSulfur Conversion to Multifunctional Poly(O-thiocarbamate)s through Multicomponent Polymerizations of Sulfur, Diols, and Diisocyanides, Formula: C13H26N2, the publication is Journal of the American Chemical Society (2021), 143(10), 3944-3950, database is CAplus and MEDLINE.

Sulfur, which is generated from the waste byproducts in the oil and gas refinery industry, is an abundant, cheap, stable, and readily available source in the world. However, the utilization of excessive amounts of sulfur is mostly limited, and developing novel methods for sulfur conversion is still a global concern. Here, the authors report a facile one-step conversion from elemental sulfur to functional poly(O-thiocarbamate)s through a multicomponent polymerization of sulfur, diols, and diisocyanides, which possesses a series of advantages such as mild condition (55°C), short reaction time (1 h), 100% atom economy, and without any transition metal in the catalyst system. Seven poly(O-thiocarbamate)s are constructed with high yields (up to 95%), large mol. weight (up to 53100 of M_w), good solubility in organic solvents, and completely new polymer structures. The poly(O-thiocarbamate)s possess a high refractive index above 1.7 from 600 to 1700 nm by adjusting the sulfur content. By incorporating tetraphenylethene (TPE) moieties into the polymer structure, the poly(O-thiocarbamate)s can also be designed as fluorescent sensors to detect the harmful metal cation Hg²⁺ in a turn-on mode with high sensitivity (LOD = 32 nM) and excellent selectivity (over interference cations of Pb²⁺, Au³⁺, Ag⁺). Different from the previous reports, the exact coordination structure is first identified by single-crystal X-ray diffraction, which revealed a tetracoordinated bonding mode (two sulfur and two chloride) using a model coordination compound

Journal of the American Chemical Society published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C6H12Br2, Formula: C13H26N2.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Nasyr, I. A. published the artcileSynthesis and autoxidation of methylcyclohexylbenzene, Computed Properties of 20029-52-1, the publication is Ukrainskii Khimicheskii Zhurnal (Russian Edition) (1964), 30(8), 862-7, database is CAplus.

A mixture of cyclohexyltoluenes (30.9:1.8:67.3 o-m-p-, according to chromatographic results), b₅ 103-3.5°, d₂₀ 0.9382, n²⁰_D 1.5242, was prepared by slow addition of cyclohexene to a mixture of PhMe and H₃PO₄ containing BF₃ at 20°. The optimum amounts were 1 part C₆H₁₀, 3-5 parts PhMe, and 0.3 part catalyst containing 35-55% BF₃ in excess of BF₃.H₃PO₄. Graphs were given of the rate of accumulation of hydroperoxide on air oxidation in the presence of Mn resinate at various temperatures and for various additions of base. Base accelerated the reaction; Na₂CO₃ was especially active, more so than NaOH. The concentration of hydroperoxide passed through a maximum, then fell to 0 as the oxidation continued. The reaction product contained 69.3% unreacted cyclohexyltoluenes, 1.2% x-MeC₆H₄OH, 2.8% p-cyclohexylbenzaldehyde, (b₂ 132-7°, d₂₀ 1.0302, n²⁰_D 1.5425; 2,4-dinitrophenylhydrazone m. 226-7°), 9.7% acids [(p-cyclohexylbenzoic m. 196°; Me ester m. 48-9°)(p-MeC₆H₄CO(CH₂)₄CO₂H m. 153-4°; 2,4-dinitrophenylhydrazone m. 152-3°) (p-MeC₆H₄CO₂H) [p-C₆H₄(CO₂H₂]]. These structures could be accounted for by oxidation at either or both of the benzylic positions.

Ukrainskii Khimicheskii Zhurnal (Russian Edition) published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C13H16O2, Computed Properties of 20029-52-1.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Novikov, I. N. published the artcileAutoxidation of p-dtcyclohexylbenzene, Formula: C13H16O2, the publication is Doklady Akademii Nauk SSSR (1963), 853-5, database is CAplus.

p-(C₆H₁₁)₂C₆H₄ is easily oxidized by O in the presence of Mn rosinate with or without the presence of a bases [Na₂CO₃, NaOH, (NH₄)₂CO₃]. The maximum concentration of hydroperoxide (56%) was accumulated at 110° in the presence of 6 mg. Mn rosinate/mole of the substrate, along with 2 g./mole Na₂CO₃. Temperatures above 110° tended to give lower yields of the hydroperoxide. The optimum yield was attained at 66% conversion. Higher temperatures gave more rapid consumption of O but lower yields of the hydroperoxide. The latter decomposed vigorously above 150°. Kinetic curves for typical runs are shown. Treatment of the reaction mixture with EtOH and cooling gave the recovered substrate, while the filtrate after being concentrated and treated with petr. ether gave p-C₆H₄[C₆H₁₁– OOH]₂, m. 131-2° (with H₂SO₄ this gave hydroquinone), while the filtrate gave a monohydroperoxide, m. 85-6°, which in the presence of H₂SO₄ in AcOH at 50-60° gave 75% p-cyclohexylphenol and cyclohexanone. The residues after the separation of hydroperoxides also gave some p-C₆H₁₁C₆H₄CO₂H, m. 190-1° (Me ester m. 44-5°).

Doklady Akademii Nauk SSSR published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C13H16O2, Formula: C13H16O2.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Sun, Xiaoyu published the artcileEffect of non-ionic surfactants on the adsorption of polycyclic aromatic compounds at water/oil interface: A molecular simulation study, Product Details of C13H26N2, the publication is Journal of Colloid and Interface Science (2021), 766-777, database is CAplus and MEDLINE.

Mol. simulations can provide unique insights into the adsorption and intermol. interactions of polycyclic aromatic compounds (PACs) and non-ionic surfactants at water/oil interface. Mol. dynamic simulations were performed to study the adsorption of PACs at water/oil interface, and the effect of adding non-ionic surfactants. PAC architecture, solvent type, structure and concentration of non-ionic surfactants were varied to address the complex interplay between PAC-surfactant interaction, PAC solubility, and structure-dependent PAC aggregation. PACs with multiple cores (PacM) partially adsorbed on the interface, in the form of small and loosely structured aggregates. Adding non-ionic surfactant Brij-93 induced desorption of PacM at both water/toluene and water/heptane interfaces. Another non-ionic surfactant, (EO)₅(PO)₁₀(EO)₅, also reduced the adsorption of PacM at water/toluene interface but enhanced their adsorption at water/heptane interface. PACs with a single large core strongly adsorbed on both interfaces, forming compact aggregated structures. Adding the two types of non-ionic surfactants did not induce desorption. This work identified two opposite roles of non-ionic surfactants in the adsorption of PACs, namely competition and co-adsorption, and provided useful insights into how the roles of non-ionic surfactants might be affected by their concentration, as well as the solubility and interfacial behaviors of the PACs.

Journal of Colloid and Interface Science published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C10H20O2, Product Details of C13H26N2.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Jia, Li published the artcileSynthesis and antibacterial evaluation of novel 11-O-aralkylcarbamoyl-3-O-descladinosylclarithromycin derivatives, Application In Synthesis of 20029-52-1, the publication is Bioorganic & Medicinal Chemistry Letters (2018), 28(14), 2471-2476, database is CAplus and MEDLINE.

A series of novel 11-O-aralkylcarbamoyl-3-O-descladinosylclarithromycin derivatives were designed, synthesized and evaluated for their in vitro antibacterial activity. The results showed that the majority of the target compounds displayed potent activity against erythromycin-susceptible S. pyogenes, erythromycin-resistant S. pneumoniae A22072 expressing the mef gene and S. pneumoniae AB11 expressing the mef and erm genes. Besides, most of the target compounds exhibited moderate activity against erythromycin-susceptible S. aureus ATCC25923 and B. subtilis ATCC9372. Title compounds exert favorable antibacterial activity against erythromycin-susceptible S. pyogenes with the MIC values of 0.015-0.125 μg/mL. Furthermore, title compounds showed superior activity against erythromycin-resistant S. pneumoniae A22072 with the MIC values of 0.25-0.5 μg/mL. Addnl., compound c was the most effective against all the erythromycin-resistant S. pneumoniae strains (A22072, B1 and AB11), exhibiting 8-, 8- and 32-fold more potent activity than clarithromycin, resp.

Bioorganic & Medicinal Chemistry Letters published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C13H16O2, Application In Synthesis of 20029-52-1.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Yang, Xiu published the artcileEnhanced reflection chiroptical effect of planar anisotropic chiral metamaterials placed on the interface of two media, Related Products of quinuclidine, the publication is Chinese Physics B (2020), 29(10), 107303, database is CAplus.

The strong chiroptical effect is highly desirable and has a wide range of applications in biosensing, chiral catalysis, polarization tuning, and chiral photo detection. In this work, we find a simple method to enhance the reflection CD (CDR) by placing the planar anisotropic chiral metamaterials (i.e., Z-shaped PACMs) on the interface of two media (i.e., Z-PCMI) with a large refractive index difference. The maximum reflection CDR from the complex system can reach about 0.840 when the refractive index is set as ntop = 4.0 and nbottom = 1.49, which is approx. three times larger than that of placing the Z-shaped PACMs directly on the substrate (i.e., Z-PCMS). While the min. reflection CDR is 0.157 when the refractive index is set as ntop = 1.0 and nbottom = 1.49. So we can get a large available range of reflection CDR from -0.840 to -0.157. Meanwhile, the transmission CDT remains unchanged with the refractive index ntop increment. Our in-depth research indicates that the large reflection CDR is derived from the difference of non-conversion components of the planar anisotropic chiral metamaterials’ reflection matrixes. In short, we provide a simple and practical method to enhance the chiroptical effect by changing the refractive index difference between two media without having to design a complex chiral structure.

Chinese Physics B published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C10H14N2O, Related Products of quinuclidine.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Rajagopalan, Narayanan published the artcileDegradation mechanisms of amine-cured epoxy novolac and bisphenol F resins under conditions of high pressures and high temperatures, Quality Control of 1761-71-3, the publication is Progress in Organic Coatings (2021), 106268, database is CAplus.

Projections of continued growth in the global hydrocarbon demand and fast depleting resources push the oil and gas industry to explore and produce in geol. formations with abnormal high pressures and temperatures, so-called HPHT conditions. In the present study, the largely unexplored degradation mechanisms for amine-cured epoxy novolac (EN) and bisphenol F (BPF) epoxy resins are investigated at lower limits of HPHT. Using a batch-like reactor encompassing the three relevant phases (a gas mixture of nitrogen and carbon dioxide, a hydrocarbon phase of aromatic para-xylene, and an artificial seawater phase), the conditions of high pressures and high temperatures were simulated. The EN and BPF coated steel panels were placed inside the batch reactor. In the gas phase-exposed zone, both EN and BPF remained essentially intact with no major defects. However, due to para-xylene uptake that resulted in a free volume increase (i.e. lowering of the glass transition temperature), the hydrocarbon-exposed zones of EN and BPF were partly covered by an oxide of iron, the origin of which was found to be diffusion of anodically-dissolved iron from the steel-coating interface. The enhanced resin chain mobility at the hydrocarbon-seawater interphase allowed higher rates of diffusion of seawater ions to the steel-coating interface with clear signs of coating degradation Finally, the seawater phase induced small blisters in the EN coating, whereas for BPF, a complete loss of adhesion between the coating and the substrate was observed Simulation of Rapid Gas Decompression (RGD), uncovered the role of RGD in the iron oxide formation process for both EN and BPF coatings. In summary, when compared to BPF, the EN network showed superior performance under conditions of HPHT.

Progress in Organic Coatings published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C13H26N2, Quality Control of 1761-71-3.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider