Tag: M.W=200-250

Kashida, Hiromu published the artcileInsulator base pairs for lighting-up perylenediimide in a DNA duplex, Related Products of quinuclidine, the publication is Chemistry – A European Journal (2010), 16(38), 11554-11557, S11554/1-S11554/18, database is CAplus and MEDLINE.

Perylenediimide (PDI) is highly quenched by nucleobases, which greatly restricts its application as a fluorescent probe. Here, the authors propose “insulator base pairs” tethering cyclohexane ring through D-threoninol. When “insulator base pairs” were inserted between PDI and nucleobases, the quantum yield of PDI drastically increased several thousand-fold. The “insulator base pairs” reported here also have the potential to increase the quantum yields of other fluorophores.

Chemistry – A European Journal published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C13H16O2, Related Products of quinuclidine.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Zhang, H. J. published the artcileEffect of Free-Volume Hole Fraction on Dynamic Mechanical Properties of Epoxy Resins Investigated by Pressure-Volume-Temperature Technique, COA of Formula: C13H26N2, the publication is Journal of Physical Chemistry B (2020), 124(9), 1824-1832, database is CAplus and MEDLINE.

Dynamic mech. anal. experiments were carried out to investigate the mech. properties of four types of chem. different epoxy resins. Pressure-volume-temperature (PVT) experiments were performed to determine the free-volume hole fraction (h_PVT) of each epoxy resin using the Simha-Somcynsky lattice-hole theory. Using the Williams-Landel-Ferry equation, the correlations between the relative hole fraction (1 – h_PVT^T_r/h_PVT, where h_PVT^T_r is the hole fraction at a reference temperature T_r) and four typical parameters reflecting dynamic mech. properties [storage modulus (E’), loss modulus (E”), damping factor (tanδ), and complex viscosity (|η*|)] were studied at from T_g(PVT) (the glass transition temperature determined by PVT data) to T_g(PVT) + 100°C. At from T_g(Eonset‘₎ (temperature corresponding to the intersection of the two tangent fitting lines in the E'(T) curve indicating the glassy-state and glass-transition stages) to T_g(PVT) + 100°C, the variations in the four dynamic mech. parameters with a relative hole fraction could be separated into two distinct categories: (i) log[E'(T)] and log[|η*|(T)] decreased linearly to their min. values and then remained nearly unchanged with increasing relative hole fraction, and (ii) log[E”(T)] and log[tanδ(T)] first increased monotonically to their maximum values and then decreased linearly with the increasing relative hole fraction. This study demonstrates that the PVT technique is a feasible and reliable exptl. method to determine the hole fractions of thermoset polymers.

Journal of Physical Chemistry B published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is 0, COA of Formula: C13H26N2.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Zhang, H. J. published the artcileEffect of free-volume holes on static mechanical properties of epoxy resins studied by positron annihilation and PVT experiments, Quality Control of 1761-71-3, the publication is Polymer (2020), 122225pp., database is CAplus.

The tensile, flexural, and fracture toughness properties of seven chem. different amine-cured epoxy resins were studied. Positron annihilation lifetime and pressure-volume-temperature (PVT) experiments were performed on each epoxy resin to characterize the average size and fraction, resp., of free-volume holes. A neg. correlation between hole fraction and hole size was revealed for these chem. different epoxy resins. Better tensile and flexural mech. properties (higher tensile modulus and lower tensile strain at break; higher flexural modulus, higher flexural strength, and lower flexural strain at break) were clearly observed for epoxy resins with smaller hole size and higher hole fraction. However, no clear relationship between fracture toughness and hole properties was found. The correlations between (tensile and flexural) static mech. properties and hole properties for chem. different epoxy resins should provide guidance for further improvements in the mech. properties of carbon fiber-reinforced polymers.

Polymer published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C18H20N2O12, Quality Control of 1761-71-3.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Hatter, Christine B. published the artcileMicromechanical response of two-dimensional transition metal carbonitride (MXene) reinforced epoxy composites, Name: 4,4-Diaminodicyclohexyl methane, the publication is Composites, Part B: Engineering (2020), 107603, database is CAplus.

MXenes have attracted much attention as fillers in polymer composites due to their superior elec. and mech. properties making them ideal for creating multifunctional composites. In this work, Ti₃CN-epoxy composites were prepared via solvent processing and cured with amine-based hardener. The effects of Ti₃CN content in the epoxy system on the thermal degradation behavior and micromech. properties were investigated. The extent of intercalation of epoxy between MXene flakes was analyzed by transmission electron microscopy. Nanoindentation anal. of MXene-epoxy composites exhibited improved mech. properties with increasing MXene content with highest increase to 12.8 GPa Young’s modulus for 90 wt% Ti₃CN. An increase in creep resistance of composites was observed at maximum loading of Ti₃CN by 46% compared to neat epoxy.

Composites, Part B: Engineering published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C13H26N2, Name: 4,4-Diaminodicyclohexyl methane.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Gawel, Justyna M. published the artcilePTG-0861: A novel HDAC6-selective inhibitor as a therapeutic strategy in acute myeloid leukaemia, Category: quinuclidine, the publication is European Journal of Medicinal Chemistry (2020), 112411, database is CAplus and MEDLINE.

Dysregulated Histone Deacetylase (HDAC) activity across multiple human pathologies have highlighted this family of epigenetic enzymes as critical druggable targets, amenable to small mol. intervention. While efficacious, current approaches using non-selective HDAC inhibitors (HDACi) have been shown to cause a range of undesirable clin. toxicities. To circumvent this, recent efforts have focused on the design of highly selective HDACi as a novel therapeutic strategy. Beyond roles in regulating transcription, the unique HDAC6 (with two catalytic domains) regulates the deacetylation of α-tubulin; promoting growth factor-controlled cell motility, cell division, and metastatic hallmarks. Recent studies have linked aberrant HDAC6 function in various hematol. cancers including acute myeloid leukemia and multiple myeloma. Herein, we report the discovery, in vitro characterization, and biol. evaluation of PTG-0861 (JG-265), a novel HDAC6-selective inhibitor with strong isoenzyme-selectivity (∼36x ) and low nanomolar potency (IC₅₀ = 5.92 nM) against HDAC6. This selectivity profile was rationalized via in silico docking studies and also observed in cellulo through cellular target engagement. Moreover, PTG-0861 achieved relevant potency against several blood cancer cell lines (e.g. MV4-11, MM1S), while showing limited cytotoxicity against non-malignant cells (e.g. NHF, HUVEC) and CD-1 mice. In examining compound stability and cellular permeability, PTG-0861 revealed a promising in vitro pharmacokinetic (PK) profile. Altogether, in this study we identified a novel and potent HDAC6-selective inhibitor (∼4x more selective than current clin. standards – citarinostat, ricolinostat), which achieves cellular target engagement, efficacy in hematol. cancer cells with a promising safety profile and in vitro PK.

European Journal of Medicinal Chemistry published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C13H16O2, Category: quinuclidine.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Koshel, S. G. published the artcileSynthesis of cyclohexylbenzoic acids by liquid-phase catalytic oxidation of cyclohexyltoluenes, Synthetic Route of 20029-52-1, the publication is Neftekhimiya (1989), 29(2), 257-61, database is CAplus.

Isomeric cyclohexyltoluenes were oxidized by mol. oxygen in glacial AcOH using Co(OAc)₂ as catalyst and AcH as initiator. The reactivity of the cyclohexyltoluene decreased in the order: p– > m– > o-isomer.

Neftekhimiya published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C13H16O2, Synthetic Route of 20029-52-1.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Fujiwara, Eisuke published the artcileUltrafast Spectroscopic Analysis of Pressure-Induced Variations of Excited-State Energy and Intramolecular Proton Transfer in Semi-Aliphatic Polyimide Films, Safety of 4,4-Diaminodicyclohexyl methane, the publication is Journal of Physical Chemistry B (2021), 125(9), 2425-2434, database is CAplus and MEDLINE.

The relationship between the photoexcitation dynamics and the structures of semi-aliphatic polyimides (3H-PIs) was investigated using ultrafast fluorescent emission spectroscopy at atm. and increased pressures of up to 4 GPa. The 3H-PI films exhibited prominent fluorescence with extremely large Stokes shifts (Δν > 10 000 cm^-1) through an excited-state intramol. proton transfer (ESIPT) induced by keto-enol tautomerism at the isolated dianhydride moiety. The incorporation of bulky -CH₃ and -CF₃ side groups at the diamine moiety of the PIs increased the quantum yields of the ESIPT fluorescence owing to an enhanced interchain free volume In addition, 3H-PI films emitted another fluorescence at shorter wavelengths originating from closely packed polyimide (PI) chains (in aggregated forms), which was mediated through a Foddorster resonance energy transfer (FRET) from an isolated enol form into aggregated forms. The FRET process became more dominant than the ESIPT process at higher pressures owing to an enhancement of the FRET efficiency caused by the increased dipole-dipole interactions associated with a densification of the PI chain packing. The efficiency of the FRET rapidly increased by applying pressure up to 1 GPa owing to an effective compression of the interchain free volume and addnl. gradually increased at higher pressures owing to structural and/or conformational changes in the main chains.

Journal of Physical Chemistry B published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C13H26N2, Safety of 4,4-Diaminodicyclohexyl methane.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Nara, Mayuko published the artcileWhite-Light Emission and Tunable Luminescence Colors of Polyimide Copolymers Based on FRET and Room-Temperature Phosphorescence, Quality Control of 1761-71-3, the publication is ACS Omega (2020), 5(24), 14831-14841, database is CAplus and MEDLINE.

Thermally stable copolyimide (CoPI) films exhibiting high optical transparency and room-temperature phosphorescence (RTP) were prepared by copolymerizing fluorescent dianhydride and brominated phosphorescent dianhydride with an alicyclic diamine. The CoPI films underwent a 5 wt % degradation at a temperature higher than 349°C and exhibited dual fluorescent and phosphorescent emissions owing to their efficient Forster resonance energy transfer from the fluorescent to phosphorescent dianhydride moieties in the main chains, followed by an intersystem crossing from the singlet to triplet state of the latter moiety atoms. The CoPIs displayed bright RTP under a vacuum with various colors produced when adjusting the copolymerization ratio. CoPI with 5 mol % phosphorescent moiety (CoPI-05) emitted white light with high optical transparency owing to the suppression of the PI chain aggregation that causes a yellowish coloration. The copolymerization of fluorescent and phosphorescent PI moieties can control the photoluminescent properties of PI films and is applicable to color-tunable solid-state emitters, ratiometric oxygen sensors, and solar-spectrum converters.

ACS Omega published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C13H26N2, Quality Control of 1761-71-3.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Wolosz, Dominik published the artcileEnvironmentally Friendly Synthesis of Urea-Free Poly(carbonate-urethane) Elastomers, Name: 4,4-Diaminodicyclohexyl methane, the publication is Macromolecules (Washington, DC, United States) (2022), 55(12), 4995-5008, database is CAplus.

This work presents an eco-friendly synthetic pathway toward non-isocyanate poly(carbonate-urethane)s (NIPCUs) obtained from carbon dioxide and its simple derivatives-organic carbonates. Bis(hydroxyalkyl carbamate)s synthesized from ethylene carbonate and appropriate α,ω-diamines were used as polyurethane hard segment precursors while oligocarbonate diols as soft segment ones. The structures and properties of the obtained NIPCUs were explored by means of ¹H NMR, ¹³C NMR, and FT-IR spectroscopies, MALDI-ToF mass spectrometry, DSC, and mech. testing. Based on spectroscopic data as well as model reactions, it was demonstrated that the formation of the urea bonds was suppressed due to the presence of carbonate moieties. The reaction of urea bonds with carbonate residues led to urethane group formation. In addition, the influence of the polyurethane structure on the mech. and thermal properties of the obtained polymers was studied. The obtained NIPCUs exhibited mech. properties comparable to conventional polyurethane elastomers (e.g., a tensile strength of 32 MPa and an elongation at break of 800%). The described synthetic route is an straightforward way toward the replacement of conventional polyurethanes with environmentally friendly ones.

Macromolecules (Washington, DC, United States) published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C9H8O4, Name: 4,4-Diaminodicyclohexyl methane.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Urlam, Murali K. published the artcileDevelopment of new N-arylbenzamides as STAT3 dimerization inhibitors, Computed Properties of 20029-52-1, the publication is MedChemComm (2013), 4(6), 932-941, database is CAplus and MEDLINE.

The O-tosylsalicylamide S3I-201 (10) was used as a starting point for design and synthesis of novel STAT-3 dimerization inhibitors with improved drug-like qualities. The phosphonic acid 12d and salicylic acids 13f, 13g with a shorter amide linker lacking the O-tosyl group had improved STAT-3 inhibitory activity. The equivalent potencies observed by the replacement of phosphonic acid moiety of 12d with 5-amino-2-hydroxybenzoic acid group as in 13f further validates 5-amino-2-hydroxybenzoic acid as a phosphotyrosine mimic. The salicylic acid 13f displayed improved whole cell activity. The focused library of salicylic acids 13 with benzamide linker indicated that hydrophobic heptyl and cyclohexyl are the best tolerated R groups and a biphenyl ether (as the Ar group) significantly contributes to STAT3 inhibitory activity. Our docking studies indicated that the acidic groups of 12d, 13f and 13g interact in the p-Tyr-705 binding site in a broadly similar manner, while the phenoxybenzoyl group and the cyclohexylbenzyl group occupying pY+1 and pY-X hydrophobic pockets resp. The in vitro and cell based potency of 13f warrants further development of this scaffold as STAT3 inhibitors.

MedChemComm published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C18H28B2O4, Computed Properties of 20029-52-1.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider