Tag: M.W=200-250

Sathyanarayana, Pochampalli published the artcileCopper catalyzed oxygen assisted C(CNOH)-C(alkyl) bond cleavage: a facile conversion of aryl/aralkyl/vinyl ketones to aromatic acids, SDS of cas: 20029-52-1, the publication is Organic & Biomolecular Chemistry (2015), 13(37), 9681-9685, database is CAplus and MEDLINE.

A novel copper-catalyzed aerobic oxidative C(NOH)-C(alkyl) bond cleavage reaction of aryl/aralkyl/vinyl ketones for the synthesis of aromatic/acrylic acids is described. A series of ketones having aryl/aralkyl/vinyl at the one end and Me to any higher alkyl at the other end can be selectively cleaved and converted into the corresponding acids via oxime intermediates.

Organic & Biomolecular Chemistry published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C13H16O2, SDS of cas: 20029-52-1.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Francisco, Vitor published the artcileA high-throughput screening platform to identify nanocarriers for efficient delivery of RNA-based therapies, Product Details of C13H26N2, the publication is Methods (Amsterdam, Netherlands) (2021), 13-25, database is CAplus and MEDLINE.

RNA-based therapies are highly selective and powerful regulators of biol. functions. Non-viral vectors such as nanoparticles (NPs) are very promising formulations for the delivery of RNA-based therapies but their cell targeting, cell internalization and endolysomal escape capacity is rather limited. Here, we present a methodol. that combines high-throughput synthesis of light-triggerable NPs and a high-content imaging screening to identify NPs capable of efficiently delivering different type of RNAs. The NPs were generated using polymers synthesized by Michael type addition reactions and they were designed to: (i) efficiently complex coding (mRNAs) and non-coding (miRNAs and/or lncRNAs) RNA mols., (ii) allow rapid cell uptake and cytoplasmic release of RNA mols. and (iii) target different cell types based on their composition Furthermore, light-responsive domains were attached to the polymers by distinctive methods to provide diverse disassembly strategies. The most efficient formulations were identified using cell-based assays and high-content imaging anal. This strategy allows precise delivery of RNA-based therapies and provides an effective design approach to address critical issues in non-viral gene delivery.

Methods (Amsterdam, Netherlands) published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C13H26N2, Product Details of C13H26N2.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Lambeth, Robert H. published the artcileMechanical and adhesive properties of hybrid epoxy-polyhydroxyurethane network polymers, Product Details of C13H26N2, the publication is Polymer (2019), 121881, database is CAplus.

Epoxy resins and polyurethanes are both important classes of materials with wide-ranging applications. The merging of both chemistries presents new opportunities to investigate materials with potentially unique or improved performance. In this work, a series of formulations with varying levels of epoxy and cyclic carbonate monomers were reacted with a multifunctional amine to produce network polymers with hybrid functionality. The spectroscopic, swelling, thermal-mech., tensile, and adhesive behaviors were evaluated. The materials performed as expected based on the proposed network structure as determined through small-mol. model studies. In particular, the hybrid network polymers performed admirably as adhesives with significantly improved performance over an epoxy-amine control.

Polymer published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C13H26N2, Product Details of C13H26N2.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Yoshikawa, Chiaki published the artcileWell-defined monolith morphology regulates cell adhesion and its functions, HPLC of Formula: 1761-71-3, the publication is Materials Science & Engineering, C: Materials for Biological Applications (2019), 110108, database is CAplus and MEDLINE.

Hydrophilic epoxy resin-based monoliths were employed as cell culture substrates. The monoliths were made of a porous material with a bicontinuous structure that consisted of a porous channel and a resin skeleton. Monolith disks were prepared with a skinless surface through polymerization-induced spinodal decomposition-type phase separation The pore sizes, which were well controlled by the polymerization temperature, ranged from 70 to 380 nm. The quantity of protein adsorbed per unit area and the early-stage adhesion of HepG2 cells on the monolith substrates were independent of pore size, meaning they were not affected by surface topol. Long-term cell adhesion, as indicated by adherent cell number and shape, as well as liver-specific gene expression were significantly affected by pore size. In terms of cell shape, number, and gene expression, pores of approx. 200 nm were most suitable for HepG2 cell growth. These results highlight the importance of monolith morphol. for use as a cell culture substrate. The well-controlled morphol. demonstrated in this work indicates monoliths are capable of supporting growth for various types of cells in a range of applications.

Materials Science & Engineering, C: Materials for Biological Applications published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C6H6N2O, HPLC of Formula: 1761-71-3.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Shoji, Naoyuki published the artcileEffect of conversion on epoxy resin properties: Combined molecular dynamics simulation and experimental study, Related Products of quinuclidine, the publication is Polymer (2022), 125041, database is CAplus.

We investigated epoxy resin consisting of diglycidyl ether of bisphenol A (DGEBA) and bis-(p-aminocyclohexyl)methane (PACM) and found that the d. increased and decreased in the low- and high-conversion regions, resp., by using experiments and all-atom (AA) mol. dynamics (MD) simulations. To understand this feature qual., we conducted course-grained (CG) MD simulations. For the flexible and rigid CG models, the calculated d. increased and decreased monotonically, resp., in contrast to the exptl. d. To develop a more realistic CG model, which is denoted as CG-EP, we derived angular parameters based on AA-MD simulations. It was found that the CG-EP successfully reproduced the trend of the exptl. d., suggesting the importance of mol. flexibility. In addition, the progress of the conversion monotonically increased the free volume hole size, which is consistent with the result of positron annihilation lifetime spectroscopy. Furthermore, we exptl. observed that the Young’s modulus suddenly decreased at 50%, as the conversion progressed. The CG anal. indicated that this trend was also attributed to the mol. flexibility.

Polymer published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C39H35N5O8, Related Products of quinuclidine.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Kumar, Amit published the artcileHydrogenative Depolymerization of Nylons, Synthetic Route of 1761-71-3, the publication is Journal of the American Chemical Society (2020), 142(33), 14267-14275, database is CAplus and MEDLINE.

The widespread crisis of plastic pollution demands discovery of new and sustainable approaches to degrade robust plastics such as nylons. Using a green and sustainable approach based on hydrogenation, in the presence of a ruthenium pincer catalyst at 150 oC and 70 bar H2, we report here the first example of hydrogenative depolymerization of conventional, widely used nylons, and polyamides in general. Under the same catalytic conditions, we also demonstrate the hydrogenation of a polyurethane to produce diol, diamine and methanol. Addnl., we demonstrate an example where monomers (and oligomers) obtained from the hydrogenation process can be dehydrogenated back to a poly(oligo)amide of approx. similar mol. weight, thus completing a closed loop cycle for recycling of poly-amides. Based on the exptl. and DFT studies, we propose a catalytic cycle for the process that is facilitated by metal-ligand cooperativity. Overall, this unprecedented transformation, albeit at the proof of concept level, offers a new approach towards a cleaner route to recycling nylons.

Journal of the American Chemical Society published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C13H26N2, Synthetic Route of 1761-71-3.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Lai, Zhencheng published the artcileRedox Cyclization of Amides and Sulfonamides with Nitrous Oxide for Direct Synthesis of Heterocycles, Application In Synthesis of 20029-52-1, the publication is Organic Letters (2020), 22(5), 2017-2021, database is CAplus and MEDLINE.

A redox cyclization of amides R¹C(O)NHR² (R¹ = C₆H₅, 1-naphthyl, 5-methylthiophen-2-yl, etc.; R² = Me, t-Bu, cyclopropyl, etc.) and sulfonamides 4-R³C₆H₄S(O)₂NHR⁴ (R³ = H, Me, t-Bu, Ph, OMe, Cl; R⁴ = Me, t-Bu, cyclopropyl, etc.) with nitrous oxide (N₂O) for the direct synthesis of heterocycles, e.g., I has been described. Various amides and sulfonamides could undergo directed ortho metalation (DoM) by treatment with BuLi, and the lithium intermediate could be trapped by N₂O gas to achieve redox cyclization. N₂O serves as an N-atom donor to mediate the intramol. coupling of lithium species toward heterocycle formation with free external oxidant. This protocol offers a direct synthesis of heterocycles with features of readily available starting materials, simple operation, and a broad substrate scope.

Organic Letters published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C13H16O2, Application In Synthesis of 20029-52-1.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Li, Jian-Jun published the artcileCu-Catalyzed C-H Alkenylation of Benzoic Acid and Acrylic Acid Derivatives with Vinyl Boronates, Application of 4-Cyclohexylbenzoic acid, the publication is Organic Letters (2020), 22(12), 4692-4696, database is CAplus and MEDLINE.

An efficient Cu-catalyzed C-H alkenylation with acyclic and cyclic vinyl boronates was realized for the first time under mild conditions. The scope of the vinyl borons and the compatibility with functional groups including heterocycles are superior than Pd-catalyzed C-H coupling with vinyl borons, providing a reliable access to multisubstituted alkenes and dienes. Subsequent hydrogenation of the product from the internal vinyl borons will lead to installation of secondary alkyls.

Organic Letters published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C13H16O2, Application of 4-Cyclohexylbenzoic acid.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Yang, Ya-Jun published the artcileDesign, synthesis and biological evaluation of dipeptides as novel non-covalent 20S proteasome inhibitors, Recommanded Product: 4-Cyclohexylbenzoic acid, the publication is Journal of Asian Natural Products Research (2021), 23(5), 436-451, database is CAplus and MEDLINE.

Based on the interaction modes of the natural 20S proteasome inhibitors , we have previously discovered a dipeptide . To explore the SAR around compound , we designed and synthesized a series of dipeptides () with a fragment-based strategy. Among them, nine compounds showed significant inhibitory activities against the chymotrypsin-like activity of human 20S proteasome with IC₅₀ values at the submicromolar level, which were comparable or even superior to the parent compound Meanwhile, they displayed no significant inhibition against trypsin-like and caspase-like activities of 20S proteasome. The results suggested the feasibility to design dipeptides as novel and potent 20S proteasome inhibitors.

Journal of Asian Natural Products Research published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C12H14IN, Recommanded Product: 4-Cyclohexylbenzoic acid.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Hui, Xiang published the artcileHighly efficient synthesis of novel bio-based pentamethylene dicarbamate via carbonylation of pentanediamine with ethyl carbamate over well-defined titanium oxide catalysts, Category: quinuclidine, the publication is Catalysis Science & Technology (2022), 12(7), 2315-2327, database is CAplus.

Carbonylation of pentanediamine (PDA) is a green and effective route for the synthesis of pentamethylene dicarbamate (PDC), an important intermediate compound for the preparation of polyurethanes (PUs) and other chems. In this work, TiO₂-101 and TiO₂-110 catalysts, with preferential exposure of (101) and (110) facets, resp., were prepared and studied for the carbonylation of diamines with Et carbamate (EC) to give dicarbamates, e.g., EtO₂C(CH₂)₇NHCO₂Et and I. The catalysts were characterized by various techniques, including XRD, BET, SEM, TEM, XPS, NH₃-TPD and in situ FTIR. The characterization results indicated that TiO₂ catalysts with exposed (110) and (101) facets were synthesized successfully. The overall results suggested that the (101) facets on the TiO₂ surface provide high amounts of surface Lewis acid sites that played a pivotal role in PDC formation, which gave a conversion and yield both up to 99% under optimized conditions. In situ FTIR spectroscopy clearly revealed that polyurea as an intermediate was formed in the reaction and subsequently converted to PDC catalyzed by the TiO₂ catalyst. Furthermore, the DFT results showed that the conversion of polyurea to PDC over the (101) facets was more prone to occur than the (110) facets due to the lower reaction energy barrier. In addition, the TiO₂-101 catalyst displayed excellent stability without an obvious activity decline after five cycles.

Catalysis Science & Technology published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C13H26N2, Category: quinuclidine.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider